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| 1 | ETME,a novel β-elemene derivative,synergizes with arsenic trioxide in inducing apoptosis and cell cycle arrest in hepatocarcinoma cells via a p53-dependent pathway显示文摘Arsenic trioxide(ATO)has been identified as an effective treatment for acute promyelocytic leukemia(APL)but is much less effective against solid tumors such as hepatocellular carcinoma(HCC).In the search for ways to enhance its therapeutic efficacy against solid tumors,we have examined its use in combination with a novel derivative ofβ-elemene,N-(β-elemene-13-yl)tryptophan methyl ester(ETME).Here we report the effects of the combination on cell viability,apoptosis,the cell cycle and mitochondria membrane potential(MMP)in HCC SMMC-7721 cells.We found that the two compounds acted synergistically to enhance antiproliferative activity and apoptosis.The combination also decreased the MMP,down-regulated Bcl-2 and pro-proteins of the caspase family,and up-regulated Bax and BID,all of which were reversed by the p53 inhibitor,pifithrin-α.In addition,the combination induced cell cycle arrest at the G2/M phase and reduced tumor volume and weight in an xenograft model of nude mice.Overall,the results suggest that ETME in combination with ATO may be useful in the treatment of HCC patients particularly those unresponsive to ATO alone. | Zhiying Yu Fangling Wu Liang Chen Qian Li Chaojie Wang Jinhua Dong Song-qiang Xie | 2014 | Acta Pharmaceutica Sinica B2014，4，6： | 7 |
| 2 | Ecological Environment Conservation and Restoration and Sustainable Development of Minqin Oasis显示文摘Minqin oasis in the lower reaches of the Shiyang River is a main natural barrier for the Wuwei Basin. Due to the combined influence of human activities and natural factors in the past half a century, water quality in the lower reaches of the Shiyang River decreased and ecological environment deteriorated, which influenced sustainable development of this area and surrounding area seriously. This paper analyzed current situation and reasons of the deteriorated ecological environment in the lower reaches of the Shiyang River, and proposed that water environment regulation was the primary task in the eco-environment control of Minqin area, specifically,(a) By using existing policies, accelerating the construction of water-saving agriculture in the middle reaches of the Shiyang River, water quantity in the lower reaches would be guanranted, water shortage for agricultural production and ecological use in Minqin oasis would be relieved;(b) Unreasonable human activities such as overexploitation of underground water should be controlled strictly;(c) Water conservancy project should be developed vigorously to ensure rate of flow. It was expected that the above schemes would contribute to the benign circulation of ecological environment in Minqin oasis. | WANG Lide YAO Tuo XU Feng HAN Fugui GUO Chunxiu WANG Fangling Li Faming | 2016 | Journal of Landscape Research2016，8，1： | 2 |
| 3 | Economy Analysis of Flexible LCC-HVDC Systems with Controllable Capacitors显示文摘Commutation failure(CF)is a frequent dynamic event at inverter of LCC-HVDC systems caused by AC side faults which can lead to inverter blocking,interruption of active power transfer,and even system blackout.To eliminate CFs and improve system performance,new Flexible LCC-HVDC topologies have been proposed in previous research but with limited analysis on its economic performance.Therefore,to further validate the applicability of Flexible LCC-HVDC topologies,this paper utilizes Life-Cycle Cost Analysis model to analyze the life-cycle cost of inverter stations for conventional LCCHVDC,Capacitor Commutated Converter based HVDC(CCCHVDC)topology and Flexible LCC-HVDC topologies including Controllable Capacitor based Flexible LCC-HVDC,AC Filterless Controllable Capacitor based Flexible LCC-HVDC and improved Flexible LCC-HVDC.Through a case study based on a 500 kV,1000 MW LCC-HVDC scheme,comparison results show that the AC Filterless Controllable Capacitor based Flexible LCCHVDC topology and the improved Flexible LCC-HVDC topology have lower cost than the conventional LCC-HVDC and CCCHVDC topologies,which proves that the elimination of CFs can be achieved with reduced cost. | Nan Chen Kunpeng Zha Haitao Qu Fangling Li Ying Xue Xiao-Ping Zhang | 2022 | CSEE Journal of Power and Energy Systems2022，8，6： | 2 |
| 4 | Bioactivated in vivo assembly(BIVA)peptide-tetraphenylethylene(TPE)probe with controllable assembled nanostructure for cell imaging显示文摘The emergence of fluorescent light-up molecular probe,which can specifically turn on their fluorescent in the presence of stimulation factors,has open up a new opportunity to advance biosensing and bioimaging.In this work,we designed and synthesized a peptide-AIE conjugate probe for cell imaging with controlled in situ assembled nanostructures.The modular designed probe is consisted of a selfassembled peptide-tetraphenylethene(TPE)motif,a fibroblast activation protein alpha(FAP-α)responsive motif,a hydrophilic motif and a targeting motif.The probe exhibits typically turn-on fluorescence property specifically triggered by FAP-α,which is a significant overexpressed membrane protein on pancreatic tumor cells.Interestingly,the peptide modified the TPE dramatically impacts the assembled nanostructure,which can be modulated by peptide sequences.As a result,the peptide FF(PhePhe)modification of TPE as the self-assembled motif provides a suitable balance of the probe with lightup property and nanofiber assembled structure in situ.Finally,our probe could effectively detect the FAP-αon tumor cells with high specificity.Meantime,the nanofibers in situ assembled on the surface of CAFs enhanced the probe accumulation and prolonged the retention for cell imaging.We envision that this study may inspire new insights into the design of nanostructure controlled AIE light-up bio-probe. | Shizhao Lu Xiaoyan Guo Fangling Zhang Xiaodong Li Meishuai Zou Li-Li Li | 2021 | Chinese Chemical Letters2021，32，6： | 2 |
| 5 | Photocatalytic decarboxylative coupling between α-oxocarboxylicacids and alkenes显示文摘Photocatalytic decarboxylative cross-coupling which achieves the derivatization of widespread organic acids has become a hot topic in organic synthesis.As special acids,α-oxocarboxylicacids show the great potential in running decarboxylation to construct ketone derivatives.In this article,we have developed a photocatalytic decarboxylative cross-coupling ofα-oxocarboxylic acids and olefins to the synthesis of diverse aryl ketones.Various alkenes andα-oxocarboxylicacids were compatible,generating the desired products in up to 90%yield.Preliminary mechanism studies suggest that a free radical pathway is involved in this process. | Ziyue Chen Fangling Lu Feng Yuan Juanjuan Sun Linyu Du Zhen Li Meng Gao Renyi Shi Aiwen Lei | 2019 | Science China Chemistry2019，62，11： | 2 |
| 6 | Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity显示文摘 | Wen Wang Fangling Sun Yi An Houxi Ai Li Zhang Wenting Huang Lin Li | 2009 | European Journal of Pharmacology2009，，1： | 1 |
| 7 | Morroniside Prevents Peroxide-induced Apoptosis by Induction of Endogenous Glutathione in Human Neuroblastoma Cells显示文摘 | Wen Wang Wenting Huang Lin Li Houxi Ai Fangling Sun Ci Liu Yi An | 2008 | Cellular and Molecular Neurobiology2008，，2： | 1 |
| 8 | Simula-tion of Sediment Retention Effects of the Single Seabuckthorn Flexible Dam in the Pisha Sandstone Area显示文摘 | YANG Fangle CAO Mingming LI Huaien | 2013 | Ecological Engineering2013，52，3： | 1 |
| 9 | The study on psychological resilience of tinnitus and associated influencing factors显示文摘The association between tinnitus and psychological resilience is an underdeveloped area of research.This cross-sectional study investigated such associations and factors potentially affecting resilience in 61 patients.Demographic and psychometric data were collected by questionnaires.The ConnoreDavidson Resilience Scale(CD-RISC),Medical Coping Modes Questionnaire(MCMQ),Satisfaction with Life Scale(SWLS),General Self-Efficacy Scale(GSES),Big Five Inventory(BFI)and Perceived Social Support Scale(PSSS)were completed by participants.Data were analyzed using independent t-test and Pearson's correlation analysis and multiple linear regression modeling.The CD-RISC score was relatively low(66.97±15.71),negatively correlated with tinnitus(r=0.276,p<0.001)and associated with age(r=0.270,P<0.001).As protective factors,SWLS(r=0.486,p<0.001),GSES(r=0.555,p<0.001),PSSS(r=0.538,p<0.001)and extraversion were positively correlated with CD-RISC and BFI scores(r=0.287,p<0.001).We also detected a negative correlation with neuroticism(r=0.395,p<0.001),which is a known risk factor for worse CD-RISC scores.Identifying protective and risk factors for psychological resilience can be used to predict treatment outcomes in tinnitus patients,which will help devise personalized solutions and improve patients'quality of life. | Feng Xin Qingfeng Li Fangling Guan Minli Suo Jie Yang Dan Li Changqing Zhao | 2022 | Journal of Otology2022，17，1： | 1 |
| 10 | Surgical instruments hyalinization:Occlusion removal in minimally invasive endoscopic surgery显示文摘Minimal invasion is an important trend in surgery.However,the endoscope,as one of the key devices for monitoring the process of minimally invasive surgery,is limited by its size and working space it operates in,which result in a considerably narrow field of view.In particular,when a surgical instrument enters through the tool channel,the instrument occupies most of the area in an endoscopic image.This hampers the surgeon’s field of view and has a negative impact on the surgery.This study proposes a novel method for removing the occlusion caused by surgical instruments in endoscopic images by making foreground occlusions on endoscopic images transparent using image restoration and interframe information filling.Compared with unprocessed images,this method can provide a clearer field of view that is necessary for minimally invasive endoscopic surgeries and improve the quality of surgeries.Clinical endoscopic images are used to verify the feasibility of the proposed method,and the results show that the proposed method improves the visual effect of endoscopic images by removing surgical-instrument occlusions.This demonstrates the considerable potential of the proposed method for use in clinical applications. | Dongsheng Xie Wenxin Chen Jin Zhao Xinya Song Kaifeng Wang Weiwei Xia Haiying Liu Fangle Chang Changsheng Li Xingguang Duan | 2023 | Biomimetic Intelligence & Robotics2023，3，3： | 1 |
| 11 | Temperature-dependent structural changes of[Bmim]FeCl4 magnetic ionic liquid characterized by an in-situ X-ray absorption fine structure显示文摘The temperature-dependent structural changes in 1-butyl-3-methylimidazolium tetrafluoride([Bmim]FeCl4)magnetic ionic liquid(MIL)were investigated by using in-situ X-ray absorption fine structure(XAFS)combined with Raman spectroscopy and DFT calculations.XAFS re sults revealed that the coordination number and bond length of Fe-Cl in the anion of[Bmim]FeCl4 MIL decreased with increments in temperature.These results directly reflected the dissociation of tetrahedral structure[FeCl4]^-,and the formation of bridge-chain[Fe2 Cl5]^+,and[FeCl2]^+species in the anion of[Bmim]FeCl4 MIL.These behaviors indicated that[FeCl4]^-dissociation was endothermic,and was promoted by increased temperature.The results obtained through XAFS were in agreement with those obtained through Raman spectroscopy and DFT calculations. | Fangling Jiang Hao Peng Cheng Li Haiying Fu Guozhong Wu | 2020 | Chinese Chemical Letters2020，31，3： | 1 |
| 12 | Drug adulteration analysis based on complexation with cyclodextrin and metal ions using ion mobility spectrometry显示文摘Drug adulteration and contamination are serious threats to human health therefore,their accurate monitoring is very important.Allopurinol(Alp)and theophylline(Thp)are commonly used drugs for the treatment of gout and bronchitis,while their isomers hypoxanthine(Hyt)and theobromine(Thm)have no effect and affect the efficacy of the drug.In this work,the drug isomers of Alp/Hyt and Thp/Thm are simply mixed withα-,β-,γ-cyclodextrin(CD)and metal ions and separated using trapped ion mobility spectrometry-mass spectrometry(TIMS-MS).TIMS-MS results showed that Alp/Hyt and Thp/Thm isomers could interact with CD and metal ions and form corresponding binary or ternary complexes to achieve their TIMS separation.Different metal ions and CDs showed different separation effect for the isomers,among which Alp and Hyt could be successfully distinguished from the complexes of[Alp/Hyt+γ-CD+Cu–H]^(+)with separation resolution(RP–P)of 1.51;whereas Thp and Thm could be baseline separated by[Thp/Thm+γ-CD+Ca–H]^(+)with RP–P of 1.96.Besides,chemical calculations revealed that the complexes were in the inclusion forms,and microscopic interactions were somewhat different,making their mobility separation.Moreover,relative and absolute quantification was investigated with an internal standard to determine the precise isomers content,and good linearity(R^(2)>0.99)was obtained.Finally,the method was applied for the adulteration detection where different drugs and urine were analyzed.In addition,due to the advantages of fast speed,simple operation,high sensitivity,and no chromatographic separation required,the proposed method provides an effective strategy for the drug adulteration detection of isomers. | Zhigang Liang Huanhuan Wang Fangling Wu Longfei Wang Chenwei Li Chuan-Fan Ding | 2023 | Journal of Pharmaceutical Analysis2023，13，3： | 0 |
| 13 | Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis显示文摘Rheumatoid arthritis is a chronic,systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate.Several drugs have been used for the treatment of rheumatoid arthritis,but their use is limited by suboptimal bioavailability,serious adverse effects,and nonnegligible first-pass effects.In contrast,transdermal drug delivery systems(TDDSs)can avoid these drawbacks and improve patient compliance,making them a promising option for the treatment of rheumatoid arthritis(RA).Of course,TDDSs also face unique challenges,as the physiological barrier of the skin makes drug delivery somewhat limited.To overcome this barrier and maximize drug delivery efficiency,TDDSs have evolved in terms of the principle of transdermal facilitation and transdermal facilitation technology,and different generations of TDDSs have been derived,which have significantly improved transdermal efficiency and even achieved individualized controlled drug delivery.In this review,we summarize the different generations of transdermal drug delivery systems,the corresponding transdermal strategies,and their applications in the treatment of RA. | Yuyi Xu Ming Zhao Jinxue Cao Ting Fang Jian Zhang Yanli Zhen Fangling Wu Xiaohui Yu Yaming Liu Ji Li Dongkai Wang | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 14 | Conformation Changes of Enkephalin in Coordination with Pb^(2+) Investigated by Gas Phase Hydrogen/Deuterium Exchange Mass Spectrometry Combined with Theoretical Calculations显示文摘In this study, the effects of lead ions(Pb^(2+)) on the conformations of leucine encephalin(LE) and methionine encephalin(ME) in gas phase were studied using hydrogen/deuterium exchange mass spectrometry(HDX-MS) and quantum chemistry theoretical calculations at the molecular level. The HDX-MS result revealed that the complexes with the monovalent compounds [LE+Pb–H]+ and [ME+Pb–H]+had a 1:1 stoichiometric ratio, and different HDX reactivates were observed in a follow of [ME+H]+>[LE+H]+>[LE+Pb–H]+> [ME+Pb–H]+. Combining the collision-induced dissociation energies of the complexes and their HDX results, it was found that the more stable the complex, the harder it was for HDX. In addition, the favo-rable conformations of the complexes were obtained by theoretical calculations, revealing that the similar coordination type with diffe-rent bond lengths was obtained. Then, the proton affinity(PA) values of the optimized complexes were calculated to interpret the HDX observations, indicating that the higher the PA values, the more difficult it was for HDX. Overall, the experiments and theoretical calculations revealed that Pb^(2+) could induce conformational changes of LE and ME, and generate ME into a more rigid conformation than LE. The results will prompt further fundamental investigations on the conformational properties of LE/ME in coordination with Pb^(2+). | HAN Jiaru WU Fangling YANG Shutong WU Xiaonan TANG Keqi LI Zhenhua DING Chuan-Fan | 2022 | Chemical Research in Chinese Universities2022，38，2： | 0 |
| 15 | Structural analysis of [Bmim]_2CuCl_4 ionic liquids in the presence of water and ethanol by XAFS technique显示文摘The structure of [Bmim]2Cu Cl4 ionic liquids(Bmim: 1-butyl-3-methylimidazolium) with different ratios of H2 O and C2H5 OH was investigated using X-ray absorption fine structure(XAFS) technique. In this study, XAFS was employed to directly probe the conformational variations of copper ions in [Bmim]2Cu Cl4 with the addition of either water or ethanol. XAFS analysis confirmed that the structure of ionic liquids gradually transformed from tetrahedral to octahedral configuration with the increase in ratio of H2 O. Our results also showed that water molecules coordinated with the copper ions of [Bmim]2Cu Cl4, leading to the conformational change in ionic liquids. However, the XAFS spectra of [Bmim]2Cu Cl4/C2H5 OH indicated no coordination of anhydrous ethanol with the copper ions of [Bmim]2Cu Cl4. The structure of [Bmim]2Cu Cl4 ionic liquids is maintained as the tetrahedral configuration in presence of ethanol. Therefore, anhydrous ethanol causes little variation in the structure of ionic liquids and it is a good solvent for the dilution of ionic liquids. | Fangling Jiang Cheng Li Haiying Fu Yaxing Wang Xiaojing Guo Guozhong Wu | 2015 | Science China Chemistry2015，58，4： | 0 |
| 16 | Design,synthesis and SAR study of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors显示文摘The abnormal activation of JAK2 kinase is closely related to the occurrence and progression of myeloproliferative neoplasms(MPNs).At present,there is still an obvious unmet medical need for selective JAK2 inhibitors in clinic.In this paper,a class of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors was obtained by combining drug design,synthesis and structure-activity relationship studies based on the previously identified lead Crizotinib.Among them,21 b exhibited high inhibitory activity against JAK2 with an IC_(50)of 9 nmol/L,moreover,it showed 276-and 184-fold selectivity over JAK1 and JAK3,respectively.Besides,21 b had a significant antiproliferative activity against HEL cells,and also inhibited the phosphorylation of JAK2 and its down-stream signaling pathway.These results indicated that2-aminopyridine compound 21 b had the potential to be developed as a selective JAK2 inhibitor for further study. | Dandan Liu Huan Ge Fangling Xu Yufang Xu Wenjun Liu Honglin Li Lili Zhu Yanyan Diao Zhenjiang Zhao | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 17 | Heat preservation,antifouling,hemostatic and antibacterial aerogel wound dressings for emergency treatment显示文摘Hemostatic dressings with multiple functions are superior to current hemostatic dressings for use in the complex situation of emergency accidents.In particular,the existing dressings lack consideration for the prevention of hypothermic shock after massive hemorrhage.In this study,gelatin(GN)and oxidized pectin(OP)were used for Schiff base cross-linking,and then polyvinyl alcohol(PVA)solution mixed with hemostatic caffeic acid(CA)was introduced to obtain aerogel substrate material(CB)after lyophilization.Polydimethylsiloxane(PDMS)and silver nanowires(Ag NWs)were used to construct a hydrophobic layer,an antibacterial layer and an infrared reflective layer on both sides of CB to prepare a multifunctional aerogel wound dressing with heat preservation,antifouling,hemostasis and antibacterial properties(PDMS-Ag NW-CB).The results showed that the infrared transmittance of PDMS-Ag NW-CB is almost 0,so that thermal energy loss from the body is minimized.The contact angles with water and blood are 129°and 120°,respectively,which have the effect of antifouling.This dressing can absorb blood quickly within 10 min,adhere to and gather platelets,and achieve hemostasis.It has good antibacterial and biocompatibility.Therefore,PDMS-Ag NW-CB has great potential in application to emergency treatment. | Fangling Li Xiaoman Han Dongdong Cao Junxia Yin Li Chen Dongmei Li Lin Cui Zhiyong Liu Xuhong Guo | 2023 | Frontiers of Materials Science2023，17，2： | 0 |
| 18 | Influence of Fe on electrocatalytic activity of iron-nitrogendoped carbon materials toward oxygen reduction reaction显示文摘The development of highly active nitrogendoped carbon-based transition metal(M-N-C)compounds for the oxygen reduction reaction(ORR)in proton exchange membrane fuel cells(PEMFCs)greatly helps reduce fuel cell cost,thus rapidly promoting their commercial applications.Among different M-N-C electrocatalysts,the series of Fe-N-C materials are highly favored because of their high ORR activity.However,there remains a debate on the effect of Fe,and rare investigations focus on the influence of Fe addition in the second heat treatment usually performed after acid leaching in the catalyst synthesis.It is thus very critical to explore the influences of Fe on the ORR electrocatalytic activity,which will,in turn,guide the design of Fe-N-C materials with enhanced performance.Herein,a series of Fe-N-C electrocatalysts are synthesize and the influence of Fe on the ORR activity are speculated both experimentally and theoretically.It is deduced that the active site lies in the structure of Fe-N4,accompanied with the addition of appropriate Fe,and the number of active sites increases without the occurrence of agglomeration particles.Moreover,it is speculated that Fe plays an important role in stabilizing N as well as constituting active sites in the second pyrolyzing process. | Lin LI Cehuang FU Shuiyun SHEN Fangling JIANG Guanghua WEI Junliang ZHANG | 2022 | Frontiers in Energy2022，16，5： | 0 |
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