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| 1 | Electrochemical Oxidative Csp^3—H/S—H Cross-Coupling with Hydrogen Evolution for Synthesis of Tetrasubstituted Olefins显示文摘Tetrasubstituted olefins are significant scaffolds as they are prevalent in many biologically active compounds and versatile building blocks for organic synthesis. Herein, we report an electrochemical oxidative Csp^3—H/S—H cross-coupling reaction, in which various tetrasubstituted olefins were prepared under base-free, transition metal-free, and oxidants-free reaction conditions. | Fangling Lu Zengzhuan Yang Tao Wang Tianhao Wang Yuying Zhang Yong Yuan Aiwen Lei | 2019 | Chinese Journal of Chemistry2019，37，6： | 5 |
| 2 | Simula-tion of Sediment Retention Effects of the Single Seabuckthorn Flexible Dam in the Pisha Sandstone Area显示文摘 | YANG Fangle CAO Mingming LI Huaien | 2013 | Ecological Engineering2013，52，3： | 1 |
| 3 | The study on psychological resilience of tinnitus and associated influencing factors显示文摘The association between tinnitus and psychological resilience is an underdeveloped area of research.This cross-sectional study investigated such associations and factors potentially affecting resilience in 61 patients.Demographic and psychometric data were collected by questionnaires.The ConnoreDavidson Resilience Scale(CD-RISC),Medical Coping Modes Questionnaire(MCMQ),Satisfaction with Life Scale(SWLS),General Self-Efficacy Scale(GSES),Big Five Inventory(BFI)and Perceived Social Support Scale(PSSS)were completed by participants.Data were analyzed using independent t-test and Pearson's correlation analysis and multiple linear regression modeling.The CD-RISC score was relatively low(66.97±15.71),negatively correlated with tinnitus(r=0.276,p<0.001)and associated with age(r=0.270,P<0.001).As protective factors,SWLS(r=0.486,p<0.001),GSES(r=0.555,p<0.001),PSSS(r=0.538,p<0.001)and extraversion were positively correlated with CD-RISC and BFI scores(r=0.287,p<0.001).We also detected a negative correlation with neuroticism(r=0.395,p<0.001),which is a known risk factor for worse CD-RISC scores.Identifying protective and risk factors for psychological resilience can be used to predict treatment outcomes in tinnitus patients,which will help devise personalized solutions and improve patients'quality of life. | Feng Xin Qingfeng Li Fangling Guan Minli Suo Jie Yang Dan Li Changqing Zhao | 2022 | Journal of Otology2022，17，1： | 1 |
| 4 | Conformation Changes of Enkephalin in Coordination with Pb^(2+) Investigated by Gas Phase Hydrogen/Deuterium Exchange Mass Spectrometry Combined with Theoretical Calculations显示文摘In this study, the effects of lead ions(Pb^(2+)) on the conformations of leucine encephalin(LE) and methionine encephalin(ME) in gas phase were studied using hydrogen/deuterium exchange mass spectrometry(HDX-MS) and quantum chemistry theoretical calculations at the molecular level. The HDX-MS result revealed that the complexes with the monovalent compounds [LE+Pb–H]+ and [ME+Pb–H]+had a 1:1 stoichiometric ratio, and different HDX reactivates were observed in a follow of [ME+H]+>[LE+H]+>[LE+Pb–H]+> [ME+Pb–H]+. Combining the collision-induced dissociation energies of the complexes and their HDX results, it was found that the more stable the complex, the harder it was for HDX. In addition, the favo-rable conformations of the complexes were obtained by theoretical calculations, revealing that the similar coordination type with diffe-rent bond lengths was obtained. Then, the proton affinity(PA) values of the optimized complexes were calculated to interpret the HDX observations, indicating that the higher the PA values, the more difficult it was for HDX. Overall, the experiments and theoretical calculations revealed that Pb^(2+) could induce conformational changes of LE and ME, and generate ME into a more rigid conformation than LE. The results will prompt further fundamental investigations on the conformational properties of LE/ME in coordination with Pb^(2+). | HAN Jiaru WU Fangling YANG Shutong WU Xiaonan TANG Keqi LI Zhenhua DING Chuan-Fan | 2022 | Chemical Research in Chinese Universities2022，38，2： | 0 |
| 5 | The Study of IgG Subclass Profiles of Anti-HBc in Populations with Different Status of HBV Infection显示文摘To study IgG subclasses for the hepatitis B virus (HBV) core antigen (anti-HBc) in different populations, a comparison was made between 104 chronic carriers (60 male and 44 female) and 434 recovered individuals (247 male and 192 female). Biochemistry analyses of AST (aspartate aminotransferase) and ALT (alanine aminotransferase) were also performed. Among the 104 chronic carriers, 21 patients were found to be ALT and AST abnormal (> 25 IU/ml). After comparing these ALT and AST abnormal patients with other ALT and AST normal chronic carriers, no statistical difference was observed in the OD values of the anti-HBe (p > 0.05). The ELISA results showed the anti-HBc IgG subclass pattern was IgG1 > IgG3 > IgG4 in chronic carriers and IgG3 > IgG1 > IgG4 in recovered individuals (p < 0.05). This result suggests the IgG1/IgG3 ratio may be related with HBV status. However, in spite of the different anti-HBc IgG1/IgG3 patterns demonstrated in different populations, both anti-HBc IgG1 and IgG3 concentrations were significantly higher in chronic carriers (p < 0.05). Therefore, both the anti-HBc IgG1/IgG3 ratio and their amounts differed. They may play a significant role in chronic carriers and recovered individuals. The anti-HBc IgG subclass profiles of chronic carriers were not changed regardless of liver inflammation, and were independent of sex and age. Cellular & Molecular Immunology. | Yu-Yen Yang Chien-Fu Huang James Cheng-Chung Wei Mei-Shang Ho Lina Wang Shyh-Jye Lin Wei-Yu Tsai Chien-Chou Lin Fangling Xu Chi-Chiang Yang | 2005 | Cellular & Molecular Immunology2005，2，5： | 0 |
| 6 | External-Oxidant-Free Electrochemical Oxidative Trifluoromethylation of Arenes Using CF3SO2Na as the CF3 Source显示文摘Summary of main observation and conclusion An efficient and environmentally benign electrochemical oxidative radical C-H trifluoromethylation of arenes by employing Langlois reagent as the CF3 source was developed in this work.Neither transition metal catalysts nor external chemical oxidants were required in this trifluoromethylation process.The reaction could be conducted in gram scale with high reaction efficiency. | Yong Deng Fangling Lu Siqi You Tianrui Xia Yifan Zheng Cuifen Lu Guichun Yang Zuxing Chen Meng Gao Aiwen Lei | 2019 | Chinese Journal of Chemistry2019，37，8： | 0 |
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