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| 1 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 2 | A novel CDK9-associated C-type cyclin in- teracts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA 显示文摘 | Wei P Garber ME Fang SM | 1998 | Cell1998，92，4： | 1 |
| 3 | Expression patterns of vascular endothelial growth factor in human cardiac allografts: association with rejection 显示文摘 | Reinders ME Fang JC Wong W | 2003 | Transplantation2003，76，1： | 1 |
| 4 | Expression patterns of vascular endothelial growth factor in human cardiac allografts:association with rejection显示文摘 | Reinders ME Fang JC Wong W | 2003 | Transplantation2003，76，1： | 1 |
| 5 | Apotential role for ET- 1 in human placental growth interactious with the insulin-like growth factor family of peptides显示文摘 | Fang Me Wanu L Word RA | 1992 | J Clin endocrinol Metab1992，74，5： | 1 |
| 6 | A novel CDK9-associated C-type cyclin interacts directly with HIV-1Tat and mediates its high-affinity,loop-specific binding to TAR RNA显示文摘 | Wei P Garber ME Fang SM | 1998 | Cell1998，92，4： | 1 |
| 7 | The interface between delirium and dementia in elderly adults 显示文摘 | Fang TG Davis D Growdon ME | 2015 | Lancet Neurol2015，14，8： | 1 |
| 8 | Study of flow-induced hemolysis using novel Couette-type blood-shearing devices显示文摘 | Zhang T Taskin ME Fang HB | 2011 | A rtif Organs2011，35，： | 1 |
| 9 | A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loopspecific binding to TAR RNA显示文摘 | Wei P Garber ME Fang SM | 1998 | Cell1998，92，4： | 1 |
| 10 | Brain lipid-binding protein(BLBP):anovel signaling system in the developing mammalian CNS显示文摘 | Fang L Hatten ME Heintz N | 1994 | Neu-ron1994，12，4： | 1 |
| 11 | Role of dNTPs in Mutagenesis显示文摘The induced mutation frequency by alkylating mutagen glycidyl methacrylate(GMA) and N-metrhyl-N'-nitro-N-nitrosoguanidine(MNNG) was investigated with or without perturbation of deoxyribounucleoside triphosphate(dNTP)poools;the influence of short treatment at different concentrations of GMA of MNNG on dNTP poos was also explored.The results indicatied that the induced mutation frequency increased greatly at high dosages of mutagen(GMA-64μg/ml,MNNG-8μg/ml)and the perturbation on dNTP pools was carried out before the treatment of mutagen;the short treatment with mutagen could induce distinct fluctuations of dNTP pools,but different mutagen might have different effects on dNTP pools.According to the results of the present study and other reports in literature,we conclude that dNTP pools may be the targets of alkylating mutagens and the fluctuations of dNTP pools are closely associated wit mutagenesis. | LEI HAI-XIN LI ZHONG-SHENG XIE DA-YING LIU BING-CI ZUO JIN AND FANG FU-DE (Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS), Beijing 100005, China) (Institute of Occupotional Medicine, Chinese Academy of Preventive Me | 1998 | Biomedical and Environmental Sciences1998，11，4： | 0 |
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