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| 1 | Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators显示文摘AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion techniques.METHODS: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale. | Sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 2 | Ⅱ trattamento chirurgico dell'alluce valgo con la tecnica di Bosch显示文摘 | Lostia R Fanari Ⅰ | | 0，，08： | 1 |
| 3 | Breathing pattern during and after maximal exercise testing in young un- trained subjects and in obese patients 显示文摘 | Salvadori A Fanari P Mazza P | 1993 | Respiration1993，60，2： | 1 |
| 4 | Conservative endoscopic retrograde treatment of upper urinary tract tumors:retrospective analysis of the last 105 cases显示文摘 | FANARI M SERRA S DE LISA A | 2011 | Urologia2011，78，3： | 1 |
| 5 | Thymosin beta 4 expression in normal skin,colon mucosa and in tumor infiltrating mast cells显示文摘 | Nemolato S Cabras T Fanari M U | | 0，，01： | 1 |
| 6 | Medical management of primary hyperparathyroidism with concomitant multiple myeloma 显示文摘 | Fanari Z Kadikoy H | 2010 | Intern Med2010，49，6： | 1 |
| 7 | Lung func- tion and methacholine responsiveness among adoles cents in an air-polluted area显示文摘 | Longhini E Fanari P Giacomotti E | 2004 | Respiration2004，71，151： | 1 |
| 8 | Medical management of primary hyper- parathyroidism with concomitant multiple myeloma显示文摘 | Fanari Z Kadikoy H | 2010 | Intern Med2010，49，6： | 1 |
| 9 | Thymosin beta 4 ex-pssion in normal skin,colon mucosa and in tumor infiltraling mast cells显示文摘 | Nemolato S Cabras T Fanari M U | 2010 | Eur J Histocilem2010，，： | 1 |
| 10 | Oxygen uptake and cardiac performance in obese and normal subjects during exercise 显示文摘 | SALVADORI A FANARI P FONTANA M | 1999 | Respiration1999，66，1： | 1 |
| 11 | Comparison of in-hospital outcomes for beta-blocker use versus none beta blocker use in patients presenting with cocaine-associated chest pain显示文摘 | Fanari Z Kennedy KK Lim MJ | 2014 | Am J Cardiol2014，113，： | 1 |
| 12 | Oxygen uptake and cardiac performance in obese and normal subjects during exercise显示文摘 | SALVADORI A FANARI P FONTANA M | | 0，，01： | 1 |
| 13 | Breathing pattern during and after maximal exercise testing in young untrained subjects and in obese patients显示文摘 | Salvadori A Fanari P Mazza P | 1993 | Respiration1993，60，2： | 1 |
| 14 | Conservative endoscop- ic retrograde treatment of upper urinary tract tumors: retrospective analysis of the last 105 cases显示文摘 | Fanari M Serra S De Lisa A | 2011 | Urolo- gia2011，78，3： | 1 |
| 15 | Lung func tion and methacholine responsiveness among adoles cents in an air-polluted area显示文摘 | Longhini E Fanari P Giacomotti E | 2004 | Respiration2004，71，： | 1 |
| 16 | Serum 25- hydroxyvitamin D levels are associated with prognosis in he- matological malignancies 显示文摘 | Thomas X Chelghoum Y Fanari N | 2011 | Hematology2011，16，5： | 1 |
| 17 | Serum 25-hydroxyvitamin D levels are associated with prognosis in hematological malignancies显示文摘 | Thomas X Chelghoum Y Fanari N | 2011 | Hematology2011，16，5： | 1 |
| 18 | Conservative endoscopic retrograde treatment of upper urinary tract tumors: retrospective analysis of the last 105 cases 显示文摘 | Fanari M Serra S De Lisa A | 2011 | Urologia2011，78，3： | 1 |
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