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| 1 | Experience with peritoneal mesothelioma at the Milan National Cancer Institute显示文摘Diffuse malignant peritoneal mesothelioma (DMPM) is an uncommon and rapidly fatal tumor.Therapeutic options have traditionally been limited and ineffective.The biologic and molecular events correlated with poor responsiveness to therapy are still poorly understood.In recent years,an innovative treatment approach involving aggressive cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy has reportedly resulted in improved outcome,as compared to historical controls.Since 1995,at the National Cancer Institute (NCI) of Milan (Italy),patients with DMPM have been treated with CRS and hyperthermic intraperitoneal chemotherapy (HIPEC).In the present paper,clinical experiences and basic science investigations on DMPM at Milan NCI are reviewed.Perioperative and long-term outcome results with CRS and HIPEC are presented.Clinico-pathological prognostic factors were investigated by multivariate analysis.The pathologic features and immunohistochemical markers related to DMPM biologic behavior were assessed in a large case-series uniformly treated at our institution.The prevalence and prognostic role of telomere maintenance mechanisms,which account for the limitless cell replicative potential of many malignancies,were studied.The dysregulation of the apoptotic pathways may play a role in the relative chemo-resistance of DMPM and a better understanding of apoptosis-related mechanisms could result in novel targeted therapeutic strategies.On this basis,the expression of survivin and other IAP family members (IAP-1,IAP-2,and X-IAP),the pro-apoptotic protein Smac/DIABLO,and antigens associated with cell proliferation (Ki-67) and apoptosis (caspase-cleaved cytokeratin-18) were analyzed.Finally,analyses of EGFR,PDGFRA and PDGFRB were performed to ascertain if deregulation of RTK could offer useful alternative therapeutic targets. | Marcello Deraco Dario Baratti Antonello Domenico Cabras Nadia Zaffaroni Federica Perrone Raffaella Villa Jenny Jocollè Maria Rosaria Balestra Shigeki Kusamura Barbara Laterza Silvana Pilotti | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 3 |
| 2 | Diffuse Malignant Peritoneal Mesothelioma: Failure Analysis Following Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)显示文摘 | D. Baratti MD S. Kusamura MD PhD A. D. Cabras MD P. Dileo MD B. Laterza MD M. Deraco MD | 2009 | Annals of Surgical Oncology2009，，2： | 2 |
| 3 | Prognostic Analysis of Clinicopathologic Factors in 49 Patients With Diffuse Malignant Peritoneal Mesothelioma Treated With Cytoreductive Surgery and Intraperitoneal Hyperthermic Perfusion显示文摘 | Marcello Deraco MD Daisuke Nonaka MD Dario Baratti MD Paolo Casali MD Juan Rosai MD Rami Younan MD Andreola Salvatore MD Antonello D. Cabras AD MD Shigeki Kusamura MD | 2006 | Annals of Surgical Oncology2006，，2： | 2 |
| 4 | Lactose malabsorption and intolerance: What should be the best clinical management?显示文摘Lactose malabsorption (LM) is the incomplete hydrolysis of lactose due to lactase deficiency, which may occur as a primary disorder or secondary to other intestinal diseases. Primary adult-type hypolactasia is an autosomal recessive condition resulting from the physiological decline of lactase activity. Different methods have been used to diagnose LM. Lactose breath test represents the most reliable technique. A recent consensus conference has proposed the more physiological dosage of 25 g of lactose and a standardized procedure for breath testing. Recently a new genetic test, based on C/T13910 polymorphism, has been proposed for the diagnosis of adult-type hypolactasia, complementing the role of breath testing. LM represents a wellknown cause of abdominal symptoms although only some lactose malabsorbers are also intolerants. Diagnosing lactose intolerance is not straightforward. Many non-malabsorber subjects diagnose themselves as being lactose intolerant. Blind lactose challenge studies should be recommended to obtain objective results. Besides several studies indicate that subjects with lactose intolerance can ingest up to 15 g of lactose with no or minor symptoms. Therefore a therapeutic strategy consists of a lactose restricted diet avoiding the nutritional disadvantages of reduced calcium and vitamin intake. Various pharmacological options are also available. Unfortunately there is insufficient evidence that these therapies are effective. Further double-blind studies are needed to demonstrate treatment effectiveness in lactose intolerance. | Paolo Usai-Satta Mariella Scarpa Francesco Oppia Francesco Cabras | 2012 | World Journal of Gastrointestinal Pharmacology and Therapeutics2012，3，3： | 2 |
| 5 | Hepatitis B virus-related liver disease in isolated anti-hepatitis B-core positive lymphoma patients receiving chemo- or chemo-immune therapy 显示文摘 | Targhetta C Cabras MG Mamusa AM | 2008 | Haematologica2008，93，6： | 1 |
| 6 | Residues of cyromazine and its metabolite melamine in celery 显示文摘 | Cabras P Spanedda L Maxia L | 1990 | Revista della Societa Italiana di Scienza dell''Alimentazione1990，19，3： | 1 |
| 7 | Validation and global uncertainty of a liquid chromatographic with diode array detection method for the screening of azoxystrobin, kresoxim-methyl, trifloxyslrobin, famoxadone, pyraclostrobin and fenamidone in grapes and wine显示文摘 | SUSANA DE MELO ABREU PIERLUIGI CABONI PAOLO CABRAS | 2006 | Analytica Chimica Acta2006，，： | 1 |
| 8 | Rotenone residues on olises and in olive oil 显示文摘 | Cabras P Caboni P Cabras M | 2002 | J Agric Food Chem2002，50，： | 1 |
| 9 | Differentiating germinal center-derived lymphomas through their cellular microenvironment显示文摘 | Carbone A Gloghini A Cabras A | 2009 | Am J Hematol2009，84，7： | 1 |
| 10 | Interactions between lacticacid bacteria and fungicides during lactic fermentationv 显示文摘 | CABRAS P MELONI M MELIS M | 1994 | J WineRes1994，5，1： | 1 |
| 11 | Synthesis and inhibitory activity of 7 geranoxy coumarin against Penicillium spe cies in citrus fruits 显示文摘 | Agnioni A Cabras P Dhallewin G | 1998 | Phytochemistry1998，47，： | 1 |
| 12 | Biotechnological implications of the salivaryproteom e显示文摘 | CASTAGNOLA M CABRAS T VITALI A | 2011 | Trends in Biotech2011，29，8： | 1 |
| 13 | High performance liquid chromatographic separation of cyromazine and its metabolite melamine显示文摘 | Cabras P Meloni M Spanedda L | 1990 | Chromatogr1990，505，： | 1 |
| 14 | Method validation for strobilurin fungicides in cereals and fruit显示文摘 | Cabras P Angioni A Garau V L | 1998 | Journal of AOAC International1998，81，6： | 1 |
| 15 | Evolutionary implications from a post-olmec pharmaco-poeia and the relevance of widespread taxa 显示文摘 | LEONTI M CABRAS S CASTELLANOS M E | 2013 | Journal ofEthnopharmacology2013，147，12： | 1 |
| 16 | High-performance hquid chromatographic separation of cyromazine and its metabolite melamine 显示文摘 | CABRAS P MELONI M SPANEDDA L | 1990 | J Chromatogr1990，，4： | 1 |
| 17 | Residue determination of some insecticides and fungicides on grapes by reversedphase high-performance liquid chromatography 显示文摘 | Cabras P P Diana and M Meloni | 1982 | J Agric Food Chem1982，30，： | 1 |
| 18 | Behavior of acylanilide and dicarboximidic fungicide residues on greenhouse tomatoes 显示文摘 | Cabras P M Meloni F M Pirisi and F Cabitza | 1985 | J Agric Food Chem1985，30，： | 1 |
| 19 | Residue levels and storage decay control in'Star Ruby' grapefruit after dip treatments with azoxystrobin显示文摘 | Schirra M Cabras P Angioni A | 2002 | Journal of Agricultural and Food Chemistry2002，50，6： | 1 |
| 20 | Lipochromes,vi-tamins,aromas and other components of virgin olive oil areaffected by processing technology 显示文摘 | RANALLI A CABRAS P IANNUCCI E | 2001 | Food Chem2001，73，4： | 1 |
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