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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Survival outcomes of right-lobe living donor liver transplantation for patients with high Model for End-stage Liver Disease scores显示文摘BACKGROUND: Controversy exists over whether living donor liver transplantation (LDLT) should be offered to patients with high Model for End-stage Liver Disease (MELD) scores. This study tried to determine whether a high MELD score would result in inferior outcomes of right-lobe LDLT. METHODS: Among 411 consecutive patients who received right-lobe LDLT at our center, 143 were included in this study. The patients were divided into two groups according to their MELD scores: a high-score group (MELD score ≥25; n=75) and a low-score group (MELD score <25; n=68). Their demographic data and perioperative conditions were compared. Univariable and multivariable analyses were performed to identify risk factors affecting patient survival. RESULTS: In the high-score group, more patients required preoperative intensive care unit admission (49.3% vs 2.9%; P<0.001), mechanical ventilation (21.3% vs 0%; P<0.001), or hemodialysis (13.3% vs 0%; P=0.005); the waiting time before LDLT was shorter (4 vs 66 days; P<0.001); more blood was transfused during operation (7 vs 2 units; P<0.001); patients stayed longer in the intensive care unit (6 vs 3 days; P<0.001) and hospital (21 vs 15 days; P=0.015) after transplantation;more patients developed early postoperative complications (69.3% vs 50.0%; P=0.018); and values of postoperative peak blood parameters were higher. However, the two groups had comparable hospital mortality. Graft survival and patient overall survival at one year (94.7% vs 95.6%; 95.9% vs 96.9%), three years (91.9% vs 92.6%; 93.2% vs 95.3%), and five years (90.2% vs 90.2%; 93.2% vs 95.3%) were also similar between the groups. CONCLUSIONS: Although the high-score group had signifi-cantly more early postoperative complications, the two groups had comparable hospital mortality and similar satisfactory rates of graft survival and patient overall survival. Therefore, a high MELD score should not be a contraindication to right-lobe LDLT if donor risk and recipient benefit are taken into full account. | Kenneth SH Chok See Ching Chan James YY Fung Tan To Cheung Albert CY Chan Sheung Tat Fan Chung Mau Lo | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 6 |
| 3 | A Model for Liquid-Diffusion Catalytically Grown Fibrous Carbon Material显示文摘A mechanism for the catalytically growth of vapor grown fibrous carbon (VGFC) preparing from the floating catalyst method has been proposed, in which liquid diffusion-determined diffusionof carbon atoms through catalyst particles is described mathematically, and the physical andchemical properties of the catalyst particIes during the growth process are taken into account.From the model the growth rate and grown length of VGFC are calculated theoretically whichcoincides with the experimental datal and the necessity of reducing gas such as hydrogen inpreparing VGFC is explained as to reduce Fe3C, which acts as intermediate catalyst shown bythe model. Fe3C formed on the surface of γ-Fe will stop the growth of carbon fiber if they cannot be reduced at once. Additionally, the growth temperature and diameter of VGFC are alsodiscussed in the paper. | Zhang, WG Cheng, HM Su, G Fan, YY Li, F Shen, ZH Zhou, BL | 1999 | Journal of Materials Science & Technology1999，15，1： | 2 |
| 4 | Transforming growth factor-β regulates tubular epithelial myofibroblast transdifferentiation in vitro显示文摘 | Fan JM Ng YY Hill PA | 1999 | Kidney Int1999，56，12： | 1 |
| 5 | Finite Element Simulation for Estimat- ing the Mechanical Properties of Multi-walled Carbon Nanotubes显示文摘 | Fan CW Liu YY Chyanbin H | 2009 | Applied Physical A: Materials Science and Processing2009，95，3： | 1 |
| 6 | Hyperhomocysteinaemia,low folate concerntrations and methylene tetrahydrofolate reductase C677T mutation in acute mesenteric venous thrombosis显示文摘 | He JA Hu XH Fan YY | 2010 | Eur J Vasc Endovasc Surg2010，39，4： | 1 |
| 7 | Dietary n-3 PUFA Alter colonocyte mitochondrial membrane composition and function显示文摘 | Chapkin RS Hong MY Fan YY | 2002 | Lipids2002，37，2： | 1 |
| 8 | Interleukin-1 induces tubular epithelial-myofibroblast transdifferentiation throug a transforming growth factor-beta1-dependent mechanism in vitro显示文摘 | Fan JM Huang XR NG YY | 2001 | J Kidney Dis2001，37，4： | 1 |
| 9 | Dietary curcumin and limo- nin suppress CD4 T-cell proliferation and interleukin-2 produc- tion in mice显示文摘 | KIM W FAN YY SMITH R | 2009 | JNutr2009，139，5： | 1 |
| 10 | Activation of the central histaminergie system is involved in hypoxia-induced stroke tolerance in adult mice 显示文摘 | Fan YY Hu WW Dai HB | 2011 | J Cereb Blood Flow Metab2011，31，1： | 1 |
| 11 | Interleukin-linduced tu- bular epithelial- myofibroblast transdifferentiation through a transforming growth factor-β- dependent mechanism in vitro 显示文摘 | Fan JM Huang XR Ng YY | 2001 | Am J Kidney Disease2001，38，： | 1 |
| 12 | Glomerular epithelial-myofibroblast transdifferentiation in the evolution of glomerular crescent formation 显示文摘 | Ng YY Fan JM Mu W | 1999 | Nephrol Dial Transplant1999，14，12： | 1 |
| 13 | Transforming growth factor-β regulats tubular epithelial-myofibroblast transdifferentiation in vitro显示文摘 | Fan JM Ng YY Hill PA | 1999 | Kidney Int1999，56，： | 1 |
| 14 | Atorvastatin attenuates theproduction of IL-lbeta, IL-6, and TNF-alpha in the hippocampus of an amyloid betal-42-induced rat model of Alzheimer's disease显示文摘 | Zhang YY Fan YC Wang M | 2013 | Clin Intcrv Aging2013，8，： | 1 |
| 15 | Two new iridoid gluc-osides from Hedyotis diffusa显示文摘 | Zhang YY Chen Y Fan CL | 2010 | Fitoterapia2010，81，6： | 1 |
| 16 | Carnosine protects against permanent cerebral ischemia in histidinc decarboxylase knockout mice by reducing glutamate excitotoxicity 显示文摘 | Shen Y He P Fan YY | 2010 | Free Radic Biol Med2010，48，5： | 1 |
| 17 | Far-infrared spectroscopy of protein higher-order structures显示文摘 | Falconer RJ Zakaria HA Fan YY | | 0，，11： | 1 |
| 18 | Interleukin-1 induces tubular epithelin myofibroblasts transdiffrentiation through a transforming growth factor-pi-dependent mechanism in vitro显示文摘 | Fan J M Huang X R Ng YY | 2001 | AM J Kidney Dis2001，37，： | 1 |
| 19 | Transforming growth factor-β regulates tubular epithelial myofibroblast transdifferentiation in vitro显示文摘 | Fan JM Ng YY Hill PA | 1999 | Kidney Int1999，56，12： | 1 |
| 20 | Overexpression of PDZ1domain prevents apoptosis of rat hippocampal neurons induced bykainic acid显示文摘 | HU SQ ZONG YY FAN LM | 2009 | Neurosci Lett2009，460，2： | 1 |
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