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| 1 | Hematological disorders and pulmonary hypertension显示文摘Pulmonary hypertension(PH),a serious disorder with a high morbidity and mortality rate,is known to occur in a number of unrelated systemic diseases.Several hematological disorders such as sickle cell disease,thalassemia and myeloproliferative diseases develop PH which worsens the prognosis.Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction.Pulmonary vascular endothelial damage/dysfunction is an early event in PH resulting in the loss of vascular reactivity,activation of proliferative and antiapoptotic pathways leading to vascular remodeling,elevated pulmonary artery pressure,right ventricular hypertrophy and premature death.Hemolysis observed in hematological disorders leads to free hemoglobin which rapidly scavenges nitric oxide(NO),limiting its bioavailability,and leading to endothelial dysfunction.In addition,hemolysis releases arginase into the circulation which converts L-arginine to ornithine,thus bypassing NO production.Furthermore,treatments for hematological disorders such as immunosuppressive therapy,splenectomy,bone marrow transplantation,and radiation have been shown to contribute to the development of PH.Recent studies have shown deregulated iron homeostasis in patients with cardiopulmonary diseases including pulmonary arterial hypertension(PAH).Several studies have reported low iron levels in patients with idiopathic PAH,and iron deficiency is an important risk factor.This article reviews PH associated with hematological disorders and its mechanism:and iron homeostasis and its relevance to PH. | Rajamma Mathew Jing Huang Joseph M Wu John T Fallon Michael H Gewitz | 2016 | World Journal of Cardiology2016，8，12： | 6 |
| 2 | Chemokine receptor-8(CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion显示文摘 | Haque NS Fallon J T Pan JJ | 2004 | Blood2004，103，6： | 1 |
| 3 | Fundamental procedures for determining ergosterol content of decaying plant material by liquied chromatography 显示文摘 | Newell S Y Arsutti T L Fallon R D | 1988 | Appl Environ Microbiol1988，54，7： | 1 |
| 4 | Synchronization of Aedes albopictus mosquito cells using hydroxyurea显示文摘 | G-enday A Blauwkamp T S Fallon A M | 1997 | Insect Molecular Biology1997，6，2： | 1 |
| 5 | Enhanced discrimination of ma-lignant from benign pancreatic disease by measuring the CA 19-9antigen on specific protein carriers显示文摘 | Yue T Maupin K A Fallon B | 2011 | PloS one2011，6，29： | 1 |
| 6 | Praziquantel-induced exposure of Schistosoma mansoni alkaline phosphatase:drug-antibody synergy which acts preferentially against femal worms显示文摘 | Fallon PG Smith P Nicholls T | 1994 | Parasie Immunol1994，16，10： | 1 |
| 7 | Mobilized peripheral blood SSC loALDHbr cells have the phenotypic and functional properties of primitive haematopoietic cells and their number correlates with engraftment following autologous transplantation 显示文摘 | Fallon P Gentry T Bailer AE | 2003 | Sr J naematol2003，122，1： | 1 |
| 8 | Assessing the ventilation effec- tiveness of naturally ventilated livestock buildings under wind dominated conditions using computational fluid dynamics显示文摘 | Norton T Grant J Fallon R | 2009 | Bio -system Engineering2009，103，1： | 1 |
| 9 | High-resolution coral records of rare Earth elements in coastal seawater:Biogeochemical cycling and a new environmental proxy显示文摘 | Wyndham T McMulloch M Fallon S | 2004 | Geochimica et Cosmochimica Acta2004，68，9： | 1 |
| 10 | Praziquantel-induced exposure of Schistosoma mansoni alkaline phosphatase:drug-antibody synergy which acts preferentially against female worms显示文摘 | Smith P Nicholls T | 1994 | Parasie Immunol1994，16，10： | 1 |
| 11 | Fixation and fate of C and N in the cyanobacterium Trichodesmium using nanometer-scale secondary ion mass spectrometry显示文摘 | Finzi-Hart J A Pett-Ridge J Weber P K Popa R Fallon S J Gunderson T Hutcheon I D Nealson K H Capone D G | | 0，，： | 1 |
| 12 | The hepatopulmonary syndrome 显示文摘 | PALMA D T FALLON M B | 2006 | J Hepatol2006，45，： | 1 |
| 13 | Praziquantel-induced exposure of Schistosoma mansoni alkaline phosphatase: drug-antibody synergy which acts preferentially against female worms显示文摘 | Fallon PG Smith P Nicholls T | 1994 | Parasit Immunol1994，16，10： | 1 |
| 14 | The flash hydropyrolysis of lignite and sub-bituminous coals to both liquid and gaseoushydrocarbon products显示文摘 | FALLON P T BHATT B STEINBERG M | 1980 | Fuel Process Technol1980，3，34： | 1 |
| 15 | Significance of the angiographic morphology of localized coronary stenosis:histopathologic correlstion显示文摘 | LEVIN D C FALLON J T | 1982 | Circulation1982，66，： | 1 |
| 16 | The status of training and education in information and computer technology of Australian nurses:A national survey 显示文摘 | Eley R Fallon T Soar J | 2008 | J Cliu Nuts2008，17，20： | 1 |
| 17 | Flash pyrolysis of coal in reactive and non-reactive gaseous environments显示文摘 | SUNDARAM M S STEINBERG M FALLON P T | 1983 | Am Chem Soc Div Fuel Chem1983，25，5： | 1 |
| 18 | The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis in vivo study by high-resolution magnetic resonance imaging显示文摘 | ROBERTO C OSENDE J I FALLON J T | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 19 | The flash hydropyrolysis of lignite and sub-bituminous coals to both liquid and gaseous hydrocarbon products显示文摘 | FALLON P T BHATT B STEINBERG M | 1980 | Fuel Process Technol1980，3，34： | 1 |
| 20 | Assessing the ventilation effectiveness of naturally ventilated livestock buildings under wind dominated conditions using computational fluid dynamics显示文摘 | Norton T Grant J Fallon R | 2009 | Biosystems Engineering2009，103，1： | 1 |
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