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| 1 | The impact of extent of pancreatic and venous resection on survival for patients with pancreatic cancer显示文摘Background:Borderline resectable pancreatic cancer may require extended resections in order to achieve tumor-free margins,especially in the case of up-front resections,but it is important to know the limits of surgical therapy in this disease.This study aimed to investigate the impact of extent of pancreatic and venous resection on short-and long-term outcomes in patients with pancreatic adenocarcinoma(PDAC).Methods:This was a retrospective study from a prospectively maintained database of pancreatic resections for PDAC.Short-and long-term outcomes were analyzed in patients having borderline resectable PDAC submitted to up-front total pancreatectomy(TP)or pancreaticoduodenectomy(PD)with simultaneous portal vein(PV)and/or superior mesenteric vein(SMV)resection.Venous resections were carried out as tangential venous resection(TVR)or segmental venous resection(SVR).Patients were divided into 4 groups:(1)PD+TVR,(2)PD+SVR,(3)TP+TVR,(4)TP+SVR.Uni-and multivariate Cox regression analysis were performed to identify factors associated with survival.Results:Ninety-nine patients were submitted to simultaneous pancreatic and venous resection for PDAC.Among them,25 were submitted to PD+TVR(25.3%),12 to PD+SVR(12.1%),23 to TP+TVR(23.2%),and 39 to TP+SVR(39.4%).Overall,major morbidity(Clavien-Dindo grade≥IIIA)was 26.3%.Thirty-and 90-day mortality were 3%and 11.1%,respectively.There were no significant differences among groups in terms of short-term outcomes.Median overall survival of patients submitted to PD+TVR was significantly higher than those to TP+SVR(29.5 vs 7.9 months,P=0.001).Multivariate analysis identified TP(HR=2.11;95%CI:1.31–3.44;P=0.002)and SVR(HR=2.01;95%CI:1.27–3.15;P=0.003)as the only independent prognostic factors for overall survival.Conclusions:Up-front TP associated to SVR was predictive of worse survival in borderline resectable PDAC.Perioperative treatments in high-risk surgical groups may improve such poor outcomes. | Matteo Serenari Giorgio Ercolani Alessandro Cucchetti Matteo Zanello Enrico Prosperi Guido Fallani Michele Masetti Raffaele Lombardi Matteo Cescon Elio Jovine | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，4： | 2 |
| 2 | In vitro postantibiotic effect and postantibiotic leukocyte enhancement of tobramyein 显示文摘 | Novelli A Mazzei T Fallani S | 1995 | J Chemother1995，7，： | 1 |
| 3 | Dynamic Granger-causal networks of electricity spot prices: A novel approach to market integration 显示文摘 | Castagneto-Gissey G Chavez M De Vico Fallani F | 2014 | Energy Economics2014，44，1： | 1 |
| 4 | Imaging functional brain connectivity patterns from high- resolution EEG and fMRI via graph theory 显示文摘 | Astolfi L De Vico Fallani F Cincotti FD | 2004 | Psychophysiology2004，44，6： | 1 |
| 5 | High-grade cervical intraepithelial neoplasia(CIN) in pregnancy:clinicotherapeutic management显示文摘 | Penna C Fallani MG Magginrelli M | 1998 | Tumori1998，84，： | 1 |
| 6 | Intestinal microbiota of 6-week-old infants across Europe: geographic influence beyond delivery mode, breast-feeding, and antibiotics显示文摘 | Fallani M Young D Scott J | 2010 | J Pediatr Gastroenterol Nutr2010，51，1： | 1 |
| 7 | Prognostic sig- nificance of high-risk HPVpersistenee after laser CO2 conization for high-grade CIN:a prospective clinical study 显示文摘 | Fallani MG Penna C Marchionni M | 2008 | Eur J Gynaecol Oncol2008，29，4： | 1 |
| 8 | Management of cervical intraep ithelial neop lasia: the role of biopsy 显示文摘 | Fambrini M Penna C Fallani MG | 2003 | Int J Gynecol Obstet2003，82，： | 1 |
| 9 | Management of cervical in- traepithelial neoplasia : the role of biopsy 显示文摘 | Fambrini M Penna C Fallani MG ct al | 2003 | Int J Gynaecol Obstet2003，82，2： | 1 |
| 10 | Detecting hibernated myocardium withSPECT and thallium-glucose-insulin infusion显示文摘 | Fallani F Corbelli C | 1995 | J Nucl Med1995，36，8： | 1 |
| 11 | Prognostic significance of high-risk HPV persistence after laser CO2 conization for high-grade CIN:a prospective clinical study显示文摘 | Fallani MG Penna C Marchionni M | 2008 | Eur J Gynaecol Oncol2008，29，4： | 1 |
| 12 | High-grade cervical intraepithelial neoplasia (CIN) in pregnancy:clinicotherapeutic management显示文摘 | Penna C Fallani MG Maggiorelli M | 1998 | Tumori1998，84，5： | 1 |
| 13 | High-grade cervical intraepithelial neoplasia (CIN)in Rregnancy:Clinicotherapeutic management显示文摘 | Penna C Fallani MG Maggiorelli M | 1998 | Tumori1998，84，5： | 1 |
| 14 | Management of cervical intraepithelial neoplasia the role of biopsy 显示文摘 | Fambrini M Penna C Fallani MG | 2003 | Inter J Gynecol Obstet2003，82，4： | 1 |
| 15 | Describing relevant in- dices from the resting state electrophysiological networks 显示文摘 | Toppi J Petti M De Vico Fallani F | 2012 | Conf Proc IEEE Eng Med Biol Soc2012，2012，： | 1 |
| 16 | Custom-made orthesis and shoes in a structured follow-up program reduces the incidence of neuropathic ulcers in high-risk diabetic foot patients显示文摘 | Rizzo L Tedeschi A Fallani E | | 0，，： | 1 |
| 17 | Neuroelectrical Hyperscanning Measures Simultaneous Brain Activity in Humans显示文摘 | Laura Astolfi Jlenia Toppi Fabrizio De Vico Fallani Giovanni Vecchiato Serenella Salinari Donatella Mattia Febo Cincotti Fabio Babiloni | 2010 | Brain Topography2010，，3： | 1 |
| 18 | Management of cervical intraepithelial neoplasia:the role of biopsy显示文摘 | Fambrini M Penna C Fallani MG | 2003 | Inter J Gynecol Obstet2003，82，2： | 1 |
| 19 | Management of cervical intraepithelial neoplasia: the role of biopsy 显示文摘 | Fambrini M Penna C Fallani MG | 2003 | Inter J Gynecol Obstet2003，82，2： | 1 |
| 20 | Management of cervical intraepithelial neoplasia: the role of biopsy 显示文摘 | Fambrini M Penna C Fallani MG | 2003 | Inter J Gynecol Obstet2003，82，2： | 1 |
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