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| 1 | Nitrate induction triggers different transcriptional changes in a high and a low nitrogen use efficiency maize inbred line显示文摘In higher plants, NO3 can induce its own uptake and the magnitude of this induction is positively related to the external anion concentration. This phenomenon has been characterized in both herbaceous and woody plants. Here,different adaptation strategies of roots from two maize(Zea mays L., ZmAGOs) inbred lines differing in nitrogen use efficiency(NUE) and exhibiting different timing of induction were discussed by investigating NO3 ‐induced changes in their transcriptome. Lo5 line(high NUE) showing the maximum rate of NO3 uptake 4 h after the provision of 200 mmol/L NO3 treatment modulated a higher number of transcripts relative to T250(low NUE) that peaked after 12 h. The two inbred lines share only 368 transcripts that are modulated by the treatment with NO3 and behaved differently when transcripts involved in anion uptake and assimilation were analyzed. T250 line responded to the NO3 induction modulating this group of Researchgenes as reported for several plant species. On the contrary,the Lo5 line did not exhibit during the induction changes in this set of genes. Obtained data suggest the importance of exploring the physiological and molecular variations among different maize genotypes in response to environmental clues like NO3 provision, in order to understand mechanisms underlying NUE. | Anita Zamboni Stefania Astolfi Sabrina Zuchi Youry Pii Katia Guardini Paola Tononi Zeno Varanini | 2014 | Journal of Integrative Plant Biology2014，56，11： | 6 |
| 2 | Iron deprivation results in a rapid but not sustained increase of the expression of genes involved in iron metabolism and sulfate uptake in tomato(Solanum lycopersicum L.) seedlings显示文摘Characterization of the relationship between sulfur and iron in both Strategy I and Strategy II plants, has proven that low sulfur availability often limits plant capability to cope with iron shortage. Here it was investigated whether the adaptation to iron deficiency in tomato (Solanum lycopersicum L.) plants was associated with an increased root sulfate uptake and translocation capacity, and modified dynamics of total sulfur and thiols accumulation between roots and shoots. Most of the tomato sulfate transporter genes belonging to Groups 1,2, and 4 were significantly upregulated in iron-deficient roots,as it commonly occurs under S-deficient conditions. The upregulation of the two high affinity sulfate transporter genes,SlST1.1 and SlST1.2, by iron deprivation clearly suggests an increased root capability to take up sulfate. Furthermore, the upregulation of the two low affinity sulfate transporter genes SlST2.1 and SlST4.1 in iron-deficient roots, accompanied by a substantial accumulation of total sulfur and thiols in shoots of iron-starved plants, likely supports an increased root-to-shoot translocation of sulfate. Results suggest that tomato plants exposed to iron-deficiency are able to change sulfur metabolic balance mimicking sulfur starvation responses to meet the increased demand for methionine and its derivatives, allowing them to cope with this stress. | Anna Rita Paolacci Silvia Celletti Giulio Catarcione Malcolm J.Hawkesford Stefania Astolfi Mario Ciaffi | 2014 | Journal of Integrative Plant Biology2014，56，1： | 4 |
| 3 | Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report显示文摘BACKGROUND Cardiac tumors are rare and complex entities.Surgery represents the cornerstone of therapy,while the role of adjuvant treatment remains unclear and,in case of relapse or metastatic disease,the prognosis is very poor.Lack of prospective,randomized clinical trials hinders the generation of high level evidence for the optimal diagnostic workup and multimodal treatment of cardiac sarcomas.Herein,we describe the multidisciplinary clinical management and molecular characterization of a rare case of cardiac myxofibrosarcoma in an elderly woman.CASE SUMMARY A 73-year-old woman presented signs and symptoms of acute left-sided heart failure.Imaging examination revealed a large,left atrial mass.With suspicion of a myxoma,she underwent surgery,and symptoms were promptly relieved.Histology showed a cardiac myxofibrosarcoma,a rare histotype of cardiac sarcoma.Eight months later,disease unfortunately relapsed,and after a multidisciplinary discussion,a chemotherapy with doxorubicin and then gemcitabine was started,achieving partial radiologic and complete metabolic response,which was maintained up to 2 years and is still present.This report is focused on the entire clinical path of our patient from diagnosis to follow-up,through surgery and strategies adopted at relapse.Moreover,due to their rarity,very little is known about the molecular landscape of myxofibrosarcomas.Thus,we also performed and described preliminary genome analysis of the tumor tissue to get further insight on mechanisms involved in tumor growth,and to possibly unveil new clinically actionable targets.CONCLUSION We report a case of cardiac myxofibrosarcoma that achieved a very good prognosis due to an integrated surgical,cardiac and oncologic treatment strategy. | Maristella Saponara Valentina Indio Carmine Pizzi Elena-Daniela Serban Milena Urbini Annalisa Astolfi Pasquale Paolisso Sofia Martin Suarez Margherita Nannini Davide Pacini Valentina Agostini Ornella Leone Valentina Ambrosini Giuseppe Tarantino Stefano Fanti Fabio Niro Francesco Buia Domenico Attinà Maria Abbondanza Pantaleo | 2019 | World Journal of Clinical Cases2019，7，19： | 2 |
| 4 | An experi- mental study of imsteady partial cavitation显示文摘 | LEROUX J B ASTOLFI J A BILLARD Y | 2004 | Journal of Fluids Engineering2004，126，2： | 1 |
| 5 | An experimental study of unsteady partial cavitation显示文摘 | LEROUX J B ASTOLFI J A BILIARD J Y | 2004 | Journal of Fluids Engineering2004，126，2： | 1 |
| 6 | Discontinuous control of nonholonomic systems显示文摘 | Astolfi A | 1996 | Systems & Control Letters1996，27，1： | 1 |
| 7 | Assessing cortical functional connectivity by linear inverse estimation and directed transfer function: simulations and application to real data 显示文摘 | L Astolfi F Cincotti D Mattia | 2005 | Clinical Neurophysiology (S1388-2457)2005，116，4： | 1 |
| 8 | Ar overview on mo- lecular biology of KIT/PDGFRA wild type (WT) gastrointestinal stronml tumours (GIST) 显示文摘 | Nannini M Biasco G Astolfi A | 2013 | J ned Genet2013，50，10： | 1 |
| 9 | Path-tracking of a tractor?trailer vehicle along rectilinear and circular paths: a Lyapunov-based approach显示文摘 | ASTOLFI A BOLZEM P LOCATELLI A | 2004 | IEEE Transactions on Robotics and Automation2004，20，1： | 1 |
| 10 | Two results for adaptive output feedback stabililization of nonlinear systems 显示文摘 | Karagianis D Astolfi A | 2003 | Automatica2003，39，7： | 1 |
| 11 | Functional characterization of substance P receptors on cultured human spinal cord astrocytes:Synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production显示文摘 | Minghetti L Astolfi M | 1997 | Glia1997，21，2： | 1 |
| 12 | Disturbance attenuation and H∞-control via measurement feedback in nonlinear sys- tems 显示文摘 | ISIDORI A ASTOLFI A | 1992 | IEEE Transactions Automatic Control1992，37，9： | 1 |
| 13 | Robust stabilization of chained systems via hybrid control显示文摘 | Prieur C Astolfi A | 2003 | IEEE Transactions on Automatic Control2003，48，10： | 1 |
| 14 | A new extremum seeking technique and its application to maximize RF heating on FTU显示文摘 | Carnevaleb D Astolfi A Centioli C | 2009 | Fusion Engineering and Design2009，84，2： | 1 |
| 15 | Disturbance attenuation and H∞ control via measurement feedback in nonlinear systems显示文摘 | Isidori A Astolfi A | 1992 | IEEE Transactions on Automatic Control1992，37，： | 1 |
| 16 | Studies on plasmid stability, cell metabolism and superoxide dismutase production by Pgk- strains of Sacharomyces cerevisiae显示文摘 | Ayub M A Z Astolfi F S Mavituna F | 1992 | Appl Microbiol Biotechnol1992，37，： | 1 |
| 17 | Imaging functional brain connectivity patterns from high- resolution EEG and fMRI via graph theory 显示文摘 | Astolfi L De Vico Fallani F Cincotti FD | 2004 | Psychophysiology2004，44，6： | 1 |
| 18 | Pediatric early T-cell precursor leukemia with NF1 deletion and high-sensitivity in vitro to tipifarnib 显示文摘 | Biagi C Astolfi A Masetti R | 2010 | Leukemia2010，24，6： | 1 |
| 19 | Excess polycation mediates efficient chitosan-based gene transfer by promoting lysosomal release of the polyplexes显示文摘 | Thibault M Astolfi M Tran-Khanh N | 2011 | Biomaterials2011，32，20： | 1 |
| 20 | Transient stabilization of multi-machine power systems with nontrivial transfer conductances 显示文摘 | Ortega R Galaz M Astolfi A | 2005 | IEEE Transactions on Automatic Control2005，50，1： | 1 |
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