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| 1 | Hepatoprotective effect of Solatium xanthocarpum fruit extract against CCl_4 induced acute liver toxicity in experimental animals显示文摘Objective:To investigate the hepatoprotective potential of Solonum xanthocarpum(Solanaceae) (S.xanthocarpum) in experimental rats to validate its traditional claim.Methods:50%ethanolic fruit extract of S.xanthocarpum(SXE,100.200 or 400 mg/kg hods weight) was administered daily for 14davs in experimental animals.Liver injury was induced chemically,by CCl4 administration (1 mL/kg i.p.).The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST),alanine aminotransferase(ALT).Serum alkaline phosphatise (SALP) and total bilirubin.Meanwhile,in vivo antioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH).superoxide dismutase(SOD) and calalase(CAT) were screened along with histopathological studies.Results:Obtained results demonstrated that the treatment with SXE significantly(P<0.05- <0.001) and dose-dcpendcntly prevented chemically induced increase in serum levels of hepatic enzymes.Furthermore.SXE significantly(up to P<0.001) reduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes GSH,SOU and catalasc towards normal levels.Histopathology of the liver tissue showed that SXE attenuated the hepatocellular necrosis and led to reduction of inflammatory cells inflltration. Conclusions:The results of this study strongly indicate the protective effect of SXE against acute liver injun which may he attributed to its hepatoprotective activity,and there by scientifically support its traditional use. | Ramesh K Gupta Talib Hussain G.Panigrahi Avik Das Gireesh Narayan Singh K Sweety Md Faiyazuddin Chandana Venkateswara Rao | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，12： | 4 |
| 2 | Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents显示文摘Objective:To assess the hepatoprotective effect of Solanum xanthocarpum(S. xanthocarpum) fruit extract against antitubercular drug-induced liver toxicity in experimental animals.Methods:Ethanolic(50%) fruit extract ofS. xanthocarpum(100, 200 and 400 mg/kg bw) was administered daily for 35 days in experimental animals. Liver toxicity was induced by combination of three antitubercular drugs [isoniazid(I) 7.5 mg/kg, rifampicin(R) 10 mg/kg and pyrazinamide(P) 35 mg/kg] given orally as suspension for 35 days in rats. The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatise(ALP), total bilirubin(TBL), albumin(ALB), total protein(TP), lactate dehydroginase(LDH), and serum cholesterol(CHL). Meanwhile,in vivoantioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH), superoxide dismutase(SOD) and catalase(CAT) were measured in rat liver homogenate. The biochemical observations were supplemented by histopathological examination.Results:The results demonstrated that treatment withS.xanthocarpumsignificantly(P<0.05-P<0.001) and dose-dependently prevented drug induced increase in serum levels of hepatic enzymes. Furthermore,S. xanthocarpumsignificantly(up toP<0.001) reduced the LPO in the liver tissue and restored activities of defence antioxidant enzymes GSH, SOD and CAT towards normal levels. Histopathology of the liver tissue showed that S. xanthocarpumattenuated the hepatocellular necrosis and led to reduction in inflammatory cells infiltration.Conclusions:The results of this study strongly indicate the protective effect of S. xanthocarpumagainst liver injury which may be attributed to its hepatoprotective activity, and thereby scientifically support its traditional use. | Talib Hussain Ramesh K Gupta Sweety K Mohd Sajid Khan Md Sarfaraj Hussain Md Arif Arshad Hussain Md Faiyazuddin Chandana Venkateswara Rao | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 3 | Anti-inflammatory and antioxidant activity of Ficus carica Linn. leaves显示文摘 | B. Ali M. Mujeeb V. Aeri S.R. Mir M. Faiyazuddin F. Shakeel | 2012 | Natural Product Research2012，，5： | 1 |
| 4 | A validated HPTLC method for determination of terbutaline sulfate in bio- logical samples: Application to pharmacokinetic study显示文摘 | Md Faiyazuddin Abdul Rauf Niyaz Ahmad | 2011 | Saudi Pharmaceutical Journal2011，3，18： | 1 |
| 5 | A validated HPTLC method for determination of terbutaline sulfate in biological samples: Application to pharmacokinetic study显示文摘 | Faiyazuddin M Rauf A Ahmad N | 2011 | Sandi Pharm J2011，19，3： | 1 |
| 6 | Aerodynam- ics and deposition effects of inhaled submicron drug aero- sol in airway diseases 显示文摘 | Faiyazuddin M Mujahid M Hussain T | 2013 | Recent Pat Inflamm Allergy Drug Diseov2013，7，1： | 1 |
| 7 | High-performance thin layer chromatographic quantification of bioactive psoralen and daidzein in leaves of Ficus carica L.显示文摘 | B. Ali M. Mujeeb V. Aeri S.R. Mir S. Ahmad N.A. Siddique M. Faiyazuddin F. Shakeel | 2011 | Natural Product Research2011，，17： | 1 |
| 8 | A validated HPTLC method for determination of terbutaline sulfate in biological samples: Application to pharmacokinetic study显示文摘 | Md. Faiyazuddin Abdul Rauf Niyaz Ahmad Sayeed Ahmad Zeenat Iqbal Sushma Talegaonkar Aseem Bhatnagar Roop K. Khar Farhan J. Ahmad | 2011 | Saudi Pharmaceutical Journal2011，，3： | 1 |
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