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| 1 | Management of hypertension in primary aldosteronism显示文摘Hypertension causes significant morbidity and mortal-ity worldwide, owing to its deleterious effects on the cardiovascular and renal systems. Primary hyperaldo-steronism(PA) is the most common cause of revers-ible hypertension, affecting 5%-18% of adults with hypertension. PA is estimated to result from bilateral adrenal hyperplasia in two-thirds of patients, and from unilateral aldosterone-secreting adenoma in approxi-mately one-third. Suspected cases are initially screened by measurement of the plasma aldosterone-renin-ratio, and may be confirmed by additional noninvasive tests. Localization of aldostosterone hypersecretion is then determined by computed tomography imaging, and in selective cases with adrenal vein sampling. Solitary adenomas are managed by laparoscopic or robotic re-section, while bilateral hyperplasia is treated with min-eralocorticoid antagonists. Biochemical cure following adrenalectomy occurs in 99% of patients, and hemo-dynamic improvement is seen in over 90%, prompting a reduction in quantity of anti-hypertensive medica-tions in most patients. End-organ damage secondary to hypertension and excess aldosterone is significantly improved by both surgical and medical treatment, asmanifested by decreased left ventricular hypertrophy, arterial stiffness, and proteinuria, highlighting the im-portance of proper diagnosis and treatment of primary hyperaldosteronism. Although numerous independent predictors of resolution of hypertension after adrenalec-tomy for unilateral adenomas have been described, the Aldosteronoma Resolution Score is a validated multifac-torial model convenient for use in daily clinical practice. | Anna Aronova Thomas J Fahey Ⅲ Rasa Zarnegar | 2014 | World Journal of Cardiology2014，6，5： | 11 |
| 2 | 澳大利亚临床共识指南:儿童卒中的诊断和急性期处理显示文摘卒中是导致儿童死亡的十大原因之一,幸存的致残患儿将面临几十年的残疾生活,给患儿及其家庭带来了巨大负担。由于安全性和有效性的证据有限,以及诊断的延误,目前卒中患儿无法接受再灌注治疗。儿童卒中诊断和急性期处理的澳大利亚临床共识指南,旨在最大限度地减少临床诊疗中的不确定性,并记录与成人卒中不同的危险因素、病因和假性卒中情况的最佳证据。临床问题的阐述来自于对2007年至2017年数据库的系统检索,但仅限于英语和儿科研究。该指南应用SIGN方法和国家健康与医学研究委员会系统对证据进行筛选和分类,通过推荐、评估、发展和评价系统(GRADE系统)对推荐进行强弱分级。该指南提供了60多项基于证据的推荐,以帮助参与院前和急症处理的临床医师快速识别儿童卒中,选择最合适的初步检查方案来确定诊断、明确病因,并选择最恰当的干预措施以挽救脑组织、预防复发。同时,指南也提供了颅内压和先天性心脏病管理方面的推荐。该指南的实施需要将院前和急诊系统重组,包括建立区域性卒中网络,建立儿科卒中疾病编码,快速MRI,以及对能够提供再灌注治疗的初级儿科卒中中心进行认证。该指南能够审核治疗的基准时间线,获得急性期的干预措施及预后判断。它还将促进澳大利亚儿童卒中登记的发展,并与国际登记处建立数据联系,以便准确收集卒中发病率、治疗和结果相关的数据。 | Medley TL Miteff C Andrews I Ware T Cheung M Monagle P Mandelstam S Wray A Pridmore C Troedson C Dale RC Fahey M Sinclair A Walsh P Stojanovski S Macka MT 徐佳丽(译) 吴川杰(译) 肖潇(译) 吕俊萱(译) 张博维(译) 吉训明(译) | 2019 | 中国脑血管病杂志2019，16，4： | 9 |
| 3 | The role of chemokines in acute and chronic hepatitis C infection显示文摘丙肝在全球保健上强加重要负担。长期的感染与典型地在肝硬化,机关失败和癌症表明的肝的进步发炎被联系。由精致的避免策略的优点,丙肝病毒(HCV ) 作为一个坚持的人的病毒成功。它有一个非凡的能力破坏使它能建立长期的感染和联系的肝疾病的有免疫力的反应。Chemokines 是低分子的重量调停的趋化性的肽进纸巾的煽动性的房间和进 lymphatics 和外部血的背的招募。因此,他们对受动器和规章的有免疫力的房间的时间、空间的分发中央。在 chemokines 和他们的血缘的受体帮助之间的相互作用塑造有免疫力的反应因此,在感染的结果上有主要影响。然而, chemokines 包括 HCV 由病毒为调整代表一个目标。HCV 被知道并且可以因此由通过改变的白血球在 vivo 破坏有免疫力的反应启用它的幸存趋化性导致损害病毒的清理和长期的低档发炎的建立在 vitro 调制 chemokine 表示。在这评论,在尖锐、长期的 HCV 感染的 chemokines 的角色被描述,一个特别重音作为有免疫力的颠覆的一个工具放了在 chemokine 调整上。我们提供一在里面部分的深度讨论在调停由 chemokines 玩了肝的纤维变性当在预示的药为这些 chemoattractants 探讨潜在的应用时。 | Stephen Fahey Eugene Dempsey Aideen Long | 2014 | Cellular & Molecular Immunology2014，11，1： | 9 |
| 4 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 5 | Knowledge, perception and practices about malaria, climate change, livelihoods and food security among rural communities of central Tanzania显示文摘Background:Understanding the interactions between malaria and agriculture in Tanzania is of particular significance when considering that they are the major sources of illness and livelihoods.The objective of this study was to determine knowledge,perceptions and practices as regards to malaria,climate change,livelihoods and food insecurity in a rural farming community in central Tanzania.Methods:Using a cross-sectional design,heads of households were interviewed on their knowledge and perceptions on malaria transmission,symptoms and prevention and knowledge and practices as regards to climate change and food security.Results:A total of 399 individuals(mean age=39.8±15.5 years)were interviewed.Most(62.41%)of them had attained primary school education and majority(91.23%)were involved in crop farming activities.Nearly all(94.7%)knew that malaria is acquired through a mosquito bite.Three quarters(73%)reported that most people get sick from malaria during the rainy season.About 50%of the respondents felt that malaria had decreased during the last 10 years.The household coverage of insecticide treated mosquito nets(ITN)was high(95.5%).Ninety-six percent reported to have slept under a mosquito net the previous night.Only one in four understood the official Kiswahili term(Mabadiliko ya Tabia Nchi)for climate change.However,there was a general understanding that the rain patterns have changed in the past 10 years.Sixty-two percent believed that the temperature has increased during the same period.Three quarters of the respondents reported that they had no sufficient production from their own farms to guarantee food security in their household for the year.Three quarters(73.0%)reported to having food shortages in the past five years.About half said they most often experienced severe food shortage during the rainy season.Conclusion:Farming communities in Kilosa District have little knowledge on climate change and its impact on malaria burden.Food insecurity is common and community-based strategies to mitigate this need to be established.The findings call for an integrated control of malaria and food insecurity interventions. | Benjamin K Mayala Carolyn A Fahey Dorothy Wei Maria M Zinga Venera M Bwana Tabitha Mlacha Susan F Rumisha Grades Stanley Elizabeth H Shayo Leonard EG Mboera | 2015 | Infectious Diseases of Poverty2015，4，1： | 2 |
| 6 | 儿科PET/CT的操作和剂量学显示文摘在儿科PET/CT诊疗领域,迄今还没有统一的CT扫描方法的指南。考虑到儿童更易受电离辐射的影响,在最短时间内和最小暴露剂量条件下提供具有诊断质量的图像十分必要。该文描述了CT辐射剂量测定以及儿童PET/CT采集的基本要点。根据对北美19所儿科PET/CT机构的调查,描述了儿科PET/CT技术的多样性。调查结果表明,尽管大多数机构采用自动管电流调制,但在实际应用中各机构间仍存在2~3倍的差异,这说明需要统一的指南。该文介绍了作者所在机构研发的多序列PET/CT采集技术,此技术可以兼顾在重要部位视野内获得有诊断质量的CT图像,以及在其余部位应用低辐射技术进行显像。这种方法使患者所受辐射剂量减少,同时将PET和具有诊断质量的CT集成在单次采集中。儿科PET/CT的标准化在保证适中水平的图像质量的同时,为患者提供了减少辐射剂量的机会。 | 王宽垠(译) 刘振(译) 兰晓莉(审校) Frederic H. Fahey Alison Goodkind Robert D. MacDougall Leah Oberg Sonja I.Ziniel Richard Cappock Michael J. Callahan Neha Kwatra S. Ted Treves Stephan D. Voss | 2019 | 中华核医学与分子影像杂志2019，39，5： | 2 |
| 7 | Impact of Prophylactic Central Neck Lymph Node Dissection on Early Recurrence in Papillary Thyroid Carcinoma显示文摘 | Tracy-Ann Moo Julie McGill John Allendorf James Lee Thomas Fahey Rasa Zarnegar | 2010 | World Journal of Surgery2010，，： | 2 |
| 8 | AIN-93 purified diets for laboratory in the rodents: Final report of the American Institute of Nutrition ad hoc Writing Committee on the reformulation of the AIN- 76A rodent diet显示文摘 | REEVES P G NIELSEN F H Jr FAHEY G C | 1993 | J Nutr1993，123，： | 1 |
| 9 | Meta-analysis of Pap test accuracy 显示文摘 | Fahey MT Irwig L Macaskill P | 1995 | Am J Epidemiol1995，141，7： | 1 |
| 10 | Soybean hull as a dietary fiber source for dogs显示文摘 | Cole J T Fahey G C Merchen N R | 1999 | J Anim Sci1999，77，： | 1 |
| 11 | Diagnosing Cultural Barriers to Knowledge Management 显示文摘 | De Long D W Fahey L | 2000 | The Academy of Management Executive2000，14，4： | 1 |
| 12 | ln viw~ visualization of abdominal malignancies with acoustic radiation three elastograph显示文摘 | Fahey R J Nelson R C Bradway D P el al | 2008 | Phys MedBiol2008，53，1： | 1 |
| 13 | Selected fructooligosaccharide (l-kestose,nystose,and 1F-β-fructofuranosylnystose) composition of foods and feeds显示文摘 | CAMPBELL J M BAUER L L FAHEY G C | 1997 | Journal of Agricultural and Food Chemistry1997，45，8： | 1 |
| 14 | Acoustic radiation force inpulse imaging of the abdomen demonstration of feasibility and utility显示文摘 | Fahey BJ Nightingale KR Nelson RC | | 0，，09： | 1 |
| 15 | Sex Hormone Regulation of Innate Immunity in the Female Reproductive Tract:The Role of Epithelial Cells in Balancing Reproductive Potential with Protection against Sexually Transmitted Pathogens显示文摘 | Wira CR Fahey JV Ghosh M | | 0，，06： | 1 |
| 16 | Occurrence of glutathione in bacteria显示文摘 | Fahey R C Brown W C Adams W B | 1978 | Journal of Bacteriology1978，133，3： | 1 |
| 17 | Endovascular stents for coarctation of the aorta: initial results and inter- mediate term follow-up显示文摘 | Hamdan MA Maheshwarl S Fahey JT | 2001 | J Am Coil Cardiol2001，38，： | 1 |
| 18 | Consumption of cereal fiber,mixtures of whole grains and bran, and whole grains and riskreduction in type 2 diabetes, obesity, and cardiovascular disease显示文摘 | Cho SS Qi L Fahey GC Jr | 2013 | Am J Clin Nutr2013，98，2： | 1 |
| 19 | Effect of fiber source on short-chain fatty acid production and on the growth and toxin production by Clostridium difficile 显示文摘 | May T Mackie K I Fahey G C | 1994 | Scand J Gastroenterol1994，29，10： | 1 |
| 20 | The effect of loop electrosurgical excision procedure on future pregnancy outcome显示文摘 | Samson S L Bentley I B Fahey T J | 2005 | Obstet Gynecol2005，105，2： | 1 |
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