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	题名	作者	年代	出处	被引量
1	Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context.	Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo	2021	World Journal of Clinical Oncology2021，12，2：	3
2	Some chemical and toxicological aspects about paper mill effluent treatment with ozone显示文摘	Freire R S Kunz A Duran N	2000	Environmental Technology2000，21，：	1
3	Production of Coated Papers with Improved Properties by Using a Water-soluble Chitosan Derivative显示文摘	FERNANDES S C M FREIRE C S R SILVESTRE A J D	2010	Ind Eng Chem Res2010，49，14：	1
4	DNA vaccine against the non-structural 1 protein ( NS1 ) of dengue 2 virus显示文摘	Costa S M Freire M S Alves A M	2006	Vaccine2006，24，：	1
5	Studies on the electrochemical behavior of a eystine self-assembled monolayer modified electrode using ferro- cyanide as a probe 显示文摘	Valber A Pedrosa Thiago R L C Paixlio Renato S Freire	2007	J Electroanal Chem2007，602，2：	1
6	Geometrical nonlinearities on the static analysis of highly flexible steel cable-stayed bridges 显示文摘	Freire A M S Negrao J H O Lopes A V	2006	Computers and Struc- tures2006，，84：	1
7	Geo- metrical Nonlinearities on the Static Analysis of Highly Flexible Steel Cable-stayed Bridges显示文摘	FREIRE A M S NEGRAO J H O LOPES A V	2006	Com puters and Structures2006，84，3132：	1
8	Hydrolysis of tetrafluoroborate and hexafluorophos- phate counter ions in imidazolium-based ionic liquids 显示文摘	FREIRE M G NEVES A M S S MARRUCHO I M	2010	The Journal of Physical Chemistry A2010，114，11：	1
9	Direct electron transfer: an approach for electrochemical biosensors with higher selectivity and sensitivity显示文摘	FREIRE R S PESSOA C A MELLO L D	2003	J Braz Chem Soc2003，14，2：	1
10	Coutinho critical assessment of the formation of ionic-liquid-based aqueous two-phase systems in acidic media显示文摘	CLAUDIO A F M FERREIRA A M SHAHRIARI S FREIRE M G JOAO A P	2011	J Phys Chem B2011，115，11：	1
11	Ionic regulation and Na^+/-K^+ -ATPase activity in gills and kidney of the Antarctic aglomerular cod icefish exposed to dilute sea water显示文摘	Romao S Freire C A Fanta E	2001	J Fish Biol2001，59，2：	1
12	Geometrical nonlinearities on the static analysis of highly flexible steel cable-stayed bridges 显示文摘	Freire A M S Negrao J H O lopes A V	2006	Computers and Struc- tures2006，84，3132：	1
13	Geometrical Nonlinearities on the Static Analysis of Highly Flexible Steel Cablestayed Bridges显示文摘	Freire A M S Negrao J H O Lopes A V	2006	Computers & Structures2006，，84：	1
14	Geometrical nonlinearities on the static analysis of highly flexible steel cable-stayed bridges显示文摘	Freire A M S Negrao J H O Lopes A V	2006	Computers Structures2006，84，3132：	1
15	Geo-metrical Nonlinearities on the Static Analysis of HighlyFlexible Steel Cable-stayed Bridges显示文摘	FREIRE A M S NEGRAO J H O LOPESB A V	2006	Computers&Structures2006，84，3132：	1
16	Miscanthus×giganteus extractives:A source of valuable phenolic compounds and sterols显示文摘	Villaverde J J Domingues R M A Freire C S R	2009	Journal of Agricultural and Food Chemistry2009，57，9：	1
17	Dietary fat is as- sociated with metabolic syndrome in Japanese Brazilians显示文摘	Freire R D Cardoso M A Gimeno S G	2005	Diabetes Care2005，28，7：	1
18	Production of yellow fever virus in microcarrier-based Veto cell cuhures显示文摘	SOUZA M C FREIRE M S SCHUIZE E A	2009	Vac- cine2009，27，46：	1
19	Colour stability and opacity of resin cements and flowable composites for ceramic veneer luting after accelerated ageing显示文摘	LRP Archegas A Freire S Vieira DBM Caldas	2011	Journal of dentistry2011，39，：	1
20	Geometrical nonlinearities on the static analysis of highly flexible steel cable stayed bridges 显示文摘	Freire A M S Negrao J H O Lopes A V	2006	Computers and Structures2006，84，3132：	1

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