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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Production of Coated Papers with Improved Properties by Using a Water-soluble Chitosan Derivative显示文摘 | FERNANDES S C M FREIRE C S R SILVESTRE A J D | 2010 | Ind Eng Chem Res2010，49，14： | 1 |
| 3 | DNA vaccine against the non-structural 1 protein ( NS1 ) of dengue 2 virus显示文摘 | Costa S M Freire M S Alves A M | 2006 | Vaccine2006，24，： | 1 |
| 4 | Geometrical nonlinearities on the static analysis of highly flexible steel cable-stayed bridges 显示文摘 | Freire A M S Negrao J H O Lopes A V | 2006 | Computers and Struc- tures2006，，84： | 1 |
| 5 | Geo- metrical Nonlinearities on the Static Analysis of Highly Flexible Steel Cable-stayed Bridges显示文摘 | FREIRE A M S NEGRAO J H O LOPES A V | 2006 | Com puters and Structures2006，84，3132： | 1 |
| 6 | Hydrolysis of tetrafluoroborate and hexafluorophos- phate counter ions in imidazolium-based ionic liquids 显示文摘 | FREIRE M G NEVES A M S S MARRUCHO I M | 2010 | The Journal of Physical Chemistry A2010，114，11： | 1 |
| 7 | Coutinho critical assessment of the formation of ionic-liquid-based aqueous two-phase systems in acidic media显示文摘 | CLAUDIO A F M FERREIRA A M SHAHRIARI S FREIRE M G JOAO A P | 2011 | J Phys Chem B2011，115，11： | 1 |
| 8 | Geometrical nonlinearities on the static analysis of highly flexible steel cable-stayed bridges 显示文摘 | Freire A M S Negrao J H O lopes A V | 2006 | Computers and Struc- tures2006，84，3132： | 1 |
| 9 | Geometrical Nonlinearities on the Static Analysis of Highly Flexible Steel Cablestayed Bridges显示文摘 | Freire A M S Negrao J H O Lopes A V | 2006 | Computers & Structures2006，，84： | 1 |
| 10 | Geometrical nonlinearities on the static analysis of highly flexible steel cable-stayed bridges显示文摘 | Freire A M S Negrao J H O Lopes A V | 2006 | Computers Structures2006，84，3132： | 1 |
| 11 | Geo-metrical Nonlinearities on the Static Analysis of HighlyFlexible Steel Cable-stayed Bridges显示文摘 | FREIRE A M S NEGRAO J H O LOPESB A V | 2006 | Computers&Structures2006，84，3132： | 1 |
| 12 | Miscanthus×giganteus extractives:A source of valuable phenolic compounds and sterols显示文摘 | Villaverde J J Domingues R M A Freire C S R | 2009 | Journal of Agricultural and Food Chemistry2009，57，9： | 1 |
| 13 | Dietary fat is as- sociated with metabolic syndrome in Japanese Brazilians显示文摘 | Freire R D Cardoso M A Gimeno S G | 2005 | Diabetes Care2005，28，7： | 1 |
| 14 | Production of yellow fever virus in microcarrier-based Veto cell cuhures显示文摘 | SOUZA M C FREIRE M S SCHUIZE E A | 2009 | Vac- cine2009，27，46： | 1 |
| 15 | Geometrical nonlinearities on the static analysis of highly flexible steel cable stayed bridges 显示文摘 | Freire A M S Negrao J H O Lopes A V | 2006 | Computers and Structures2006，84，3132： | 1 |
| 16 | Phonon calculation on olivine-like LiMPO4 (M=Ni, Co, Fe) and Raman scattering of the iron-containing compound显示文摘 | PARAGUASSU W FREIRE P T C LEMOS V LALA S M MONTORO L A ROSOLEN J M | 2005 | J Raman Spectrosc2005，36，3： | 1 |
| 17 | Geometrical nonlinearities on the static analysis of highly flexible steel cable-stayed bridges 显示文摘 | FREIRE A M S | 2006 | Computers ga Structures2006，84，31： | 1 |
| 18 | Stability of lamb loin stored under refrigeration and packed in differentmodified atmosphere packaging systems显示文摘 | FERNANDES R P P FREIRE M T A de PAULA E S M | 2014 | Meat Science2014，96，1： | 1 |
| 19 | 查看详情显示文摘 | Medeiros R J G dos Santos L M Freire A S | | 0，，： | 1 |
| 20 | Lanthanide coordination compounds modeling, Sparkle/PM3 parameters for dysprosium (Ⅲ), holmium (Ⅲ) and erbium (Ⅲ) 显示文摘 | Simas A M Jagtap S Freire R O Rocha G B | 2008 | Journal of Organometallic Chemistry2008，693，： | 1 |
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