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	题名	作者	年代	出处	被引量
1	Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context.	Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo	2021	World Journal of Clinical Oncology2021，12，2：	3
2	Zn-Ni Alloy Deposits Obtained by Continuous and Pulsed Electrodeposition Processes显示文摘	PAGOTTO JR S O DE ALVARENGA FREIRE C M BALLESTER M	1999	Surface and Coatings Technology1999，122，：	1
3	Production of Coated Papers with Improved Properties by Using a Water-soluble Chitosan Derivative显示文摘	FERNANDES S C M FREIRE C S R SILVESTRE A J D	2010	Ind Eng Chem Res2010，49，14：	1
4	Application of singular value decomposition to vertical seismic profiling显示文摘	Freire S L M Ulrych T J	1988	Geophysics1988，53，6：	1
5	Antimicrobial effecl of linalool and a -terpineol against periodontopathic and cariogenic bacteria显示文摘	Park S N Lira Y K Freire M O	2012	Anaerobe2012，18，：	1
6	Application of singular value decomposition to vertical seismic profiling显示文摘	Freire S L M Ulrych T J	1988	Geophysics1988，53，6：	1
7	Effects of EDTA on signal stability during electrochemi- cal detection of acetaminophen 显示文摘	DECARVALHO R M FREIRE R S RATH S	2004	J Pharm Biomed Anal2004，34，5：	1
8	DNA vaccine against the non-structural 1 protein ( NS1 ) of dengue 2 virus显示文摘	Costa S M Freire M S Alves A M	2006	Vaccine2006，24，：	1
9	Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial显示文摘	Meduri GU Golden E Freire AX Taylor E Zaman M Carson S J	2007	Chest2007，131，4：	1
10	Antimicrobial effect of linalool and α-terpineol against periodontopathic and cariogenic bacteria显示文摘	PARK S N LIM Y K FREIRE M O		0，，：	1
11	Geometrical nonlinearities on the static analysis of highly flexible steel cable-stayed bridges 显示文摘	Freire A M S Negrao J H O Lopes A V	2006	Computers and Struc- tures2006，，84：	1
12	Geo- metrical Nonlinearities on the Static Analysis of Highly Flexible Steel Cable-stayed Bridges显示文摘	FREIRE A M S NEGRAO J H O LOPES A V	2006	Com puters and Structures2006，84，3132：	1
13	Visceral Leishmaniasis in A New Ecological Niche Near A major Metropolitan Area of Brazil 显示文摘	Cunha S Freire M Eulalio C	1995	Transactions of the Royal Society of Tropical Medicine and Hygiene1995，89，：	1
14	Hydrolysis of tetrafluoroborate and hexafluorophos- phate counter ions in imidazolium-based ionic liquids 显示文摘	FREIRE M G NEVES A M S S MARRUCHO I M	2010	The Journal of Physical Chemistry A2010，114，11：	1
15	Coutinho critical assessment of the formation of ionic-liquid-based aqueous two-phase systems in acidic media显示文摘	CLAUDIO A F M FERREIRA A M SHAHRIARI S FREIRE M G JOAO A P	2011	J Phys Chem B2011，115，11：	1
16	Geometrical nonlinearities on the static analysis of highly flexible steel cable-stayed bridges 显示文摘	Freire A M S Negrao J H O lopes A V	2006	Computers and Struc- tures2006，84，3132：	1
17	Geometrical Nonlinearities on the Static Analysis of Highly Flexible Steel Cablestayed Bridges显示文摘	Freire A M S Negrao J H O Lopes A V	2006	Computers & Structures2006，，84：	1
18	Geometrical nonlinearities on the static analysis of highly flexible steel cable-stayed bridges显示文摘	Freire A M S Negrao J H O Lopes A V	2006	Computers Structures2006，84，3132：	1
19	Geo-metrical Nonlinearities on the Static Analysis of HighlyFlexible Steel Cable-stayed Bridges显示文摘	FREIRE A M S NEGRAO J H O LOPESB A V	2006	Computers&Structures2006，84，3132：	1
20	High-performance extraction of alkaloids using aqueous two-phase systems with ionic liquids 显示文摘	Freire M G Neves C M S S Marrucho I M	2010	Green Chemistry2010，12，10：	1

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