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| 1 | Celiac disease:Prevalence,diagnosis,pathogenesis and treatment显示文摘Celiac disease(CD) is one of the most common diseases,resulting from both environmental(gluten) and genetic factors [human leukocyte antigen(HLA) and nonHLA genes].The prevalence of CD has been estimated to approximate 0.5%-1% in different parts of the world.However,the population with diabetes,autoimmune disorder or relatives of CD individuals have even higher risk for the development of CD,at least in part,because of shared HLA typing.Gliadin gains access to the basal surface of the epithelium,and interact directly with the immune system,via both trans-and para-cellular routes.From a diagnostic perspective,symptoms may be viewed as either 'typical' or 'atypical'.In both positive serological screening results suggestive of CD,should lead to small bowel biopsy followed by a favourable clinical and serological response to the gluten-free diet(GFD) to confirm the diagnosis.Positive anti-tissue transglutaminase antibody or antiendomysial antibody during the clinical course helps to confirm the diagnosis of CD because of their over 99% specificities when small bowel villous atrophy is present on biopsy.Currently,the only treatment available for CD individuals is a strict life-long GFD.A greater understanding of the pathogenesis of CD allows alternative future CD treatments to hydrolyse toxic gliadin peptide,prevent toxic gliadin peptide absorption,blockage of selective deamidation of specific glutamine residues by tissue,restore immune tolerance towards gluten,modulation of immune response to dietary gliadin,and restoration of intestinal architecture. | Naiyana Gujral Hugh J Freeman Alan BR Thomson | 2012 | World Journal of Gastroenterology2012，18，42： | 19 |
| 2 | Use of the tumor necrosis factor-blockers for Crohn's disease显示文摘The use of anti-tumor necrosis factor-therapy for inflammatory bowel disease represents the most important advance in the care of these patients since the publication of the National Co-operative Crohn's disease study thirty years ago.The recommendations of numerous consensus groups worldwide are now supported by a wealth of clinical trials and several meta-analyses.In general,it is suggested that tumor necrosis factor-blockers(TNFBs) are indicated(1) for persons with moderately-severe Crohn's disease or ulcerative colitis(UC) who have failed two or more causes of glucocorticosteroids and an acceptably long cause(8 wk to 12 wk) of an immune modulator such as azathioprine or methotrexate;(2) non-responsive perianal disease;and(3) severe UC not responding to a 3-d to 5-d course of steroids.Once TNFBs have been introduced and the patient is responsive,therapy given by the IV and SC rate must be continued.It remains open to definitive evidence if concomitant immune modulators are required with TNFB maintenance therapy,and when or if TNFB may be weaned and discontinued.The supportive evidence from a single study on the role of early versus later introduction of TNFB in the course of a patient's illness needs to be confirmed.The risk/benefit profile of TNFB appears to be acceptable as long as the patient is immunized and tested for tuberculosis and viral hepatitis before the initiation of TNFB,and as long as the long-term adverse effects on the development of lymphoma and other tumors do not prone to be problematic.Because the rates of benefits to TNFB are modest from a population perspective and the cost of therapy is very high,the ultimate application of use of TNFBs will likely be established by cost/benefit studies. | Alan BR Thomson Milli Gupta Hugh J Freeman | 2012 | World Journal of Gastroenterology2012，18，35： | 3 |
| 3 | Chaotic resonance - methods and applications for robust classification of noisy and variable patterns显示文摘 | Kozma R Freeman W J | 2001 | International Journal of Bifurcation and chaos2001，11，6： | 2 |
| 4 | Pancreatic endocrine and exocrine changes in celiac disease显示文摘Although there is a great deal of information on celiac disease and associated involvement of other non-intestinal sites,data on concomitant changes in the structure and function of the pancreas is limited. The present review critically examines pancreatic endocrine changes that have been well documented in the literature,including insulin-dependent diabetes mellitus. Pancreatic exocrine alterations may also occur,and if severe,marked malnutrition with pancreatic failure and ductal calcification have been observed. Finally,other pancreatic disorders have been recorded with celiac disease. | Hugh J Freeman | 2007 | World Journal of Gastroenterology2007，13，47： | 2 |
| 5 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 6 | Endoscopic excision of a prolapsing malignant polyp which caused intermittent gastric outlet obstruction显示文摘A 69-year-old male with chronic lymphocytic leukemia presented with iron deficiency anemia and post-prandial abdominal fullness. Endoscopy showed a large polyp on a stalk, protruding through the pylorus into the duodenum causing intermittent gastric outlet obstruction. While prolapsing gastric antral polyps are usually benign and hyperplastic, inflammatory or regenerative in type, excisional snare polypectomy here led to complete resolution of his symptoms, but showed a malignant polyp. | Hugh J Freeman | 2005 | World Journal of Gastroenterology2005，11，33： | 2 |
| 7 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 8 | Identificatin of sulfated oligosaccharide based inhibitors of tumor growth and metastasis using novel in vitro assays for anigiogenesis and heparanase activity 显示文摘 | Parish CR Freeman C Brown K J | 1999 | Cancer Res1999，59，： | 1 |
| 9 | CD4^+CD25^high regulatory cells in human peripheral blood 显示文摘 | Baecher-Allan C Brown J A Freeman G J | 2001 | J Immunol2001，167，3： | 1 |
| 10 | Performance and optimization of a combustion interface for isotope ratio monitoring gas chromatography mass spectrometry 显示文摘 | Merritt D A Freeman K H Ricci M P Studley S A Hayes J M | 1995 | Analytical Chemistry1995，67，14： | 1 |
| 11 | G-induced loss of consciousness accidents: USAF experience 1982-1990 显示文摘 | Harding R Freeman J | 1992 | Aviat Space Environ Med1992，63，1： | 1 |
| 12 | Strongly Enhanced 2D Magnetism at Surfaces and Interfaces显示文摘 | Fu CL | 1987 | J Appl Phys1987，61，： | 1 |
| 13 | Expression of aquaporin 1 and aquaporin 4 water channels in rat choroid plexus显示文摘 | Speake T Freeman L J Brown P D | 2003 | Biochim Biophys Acta2003，1609，1： | 1 |
| 14 | Measuring organizational growth : Issues, consequences and guidelines 显示文摘 | Weinzimmer L G Nystrom P C Freeman S J | 1998 | Journal of Management1998，24，2： | 1 |
| 15 | The B7 family revisited 显示文摘 | Greenwald R J Freeman GJ Sharpe AH | 2005 | Annu Rev Immunol2005，23，： | 1 |
| 16 | Real-time three-dimensional transesophageal echocardiography in the intraoperative assessment of mitral valve disease显示文摘 | Grewal J Mankad S Freeman WK | 2009 | J Am Soc Echocardiogr2009，22，1： | 1 |
| 17 | Phase stability and magnetism of Ni3A1 显示文摘 | Xu J X MIN B I FREEMAN A J | 1990 | Physical Review B: Condensed Matter1990，41，8： | 1 |
| 18 | Biocomplexity: adaptive behavior in complex stochastic dynamic systems显示文摘 | Freeman Walter J Robert Kozma | 2001 | Biosystems2001，，59： | 1 |
| 19 | Pravastatin and the development of diabetes mellitus: evidence for a protective effect in the West of Scotland Coronary Prevention Study显示文摘 | Freeman DJ Norrie J Sattar N | 2001 | Circulation2001，103，： | 1 |
| 20 | Fabrication of carbon-carbon composites by forced flow-thermal gradient chemical vapor infiltration显示文摘 | Vaidyaraman S Lackey W J Freeman G B | 1995 | J Mater Res1995，10，5： | 1 |
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