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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 3 | Coating characteristics and tribological properties of sputterdeposited MoS2/metal composite coatings deposited by closed field unbalanced magnetron sputter ion plating显示文摘 | Renevier N M Fox V C Teer D G | 2000 | Surface and Coatings Technology2000，127，： | 2 |
| 4 | Synthesis,characterization and ctalytic applications of a palladlum-nanoparticle-cored dendrlmer显示文摘 | Gopidas K R Whitesell J K Fox M A | 2003 | Nano Lett2003，3，12： | 1 |
| 5 | Characteristics of Rural Homebound Older Adults: A Community-Based study 显示文摘 | Ganguli M Fox A GilbyJ | 1996 | American Geriatric Society1996，44，： | 1 |
| 6 | Efficacy of me-mantine on behavioral and psychological symptoms related to dementia:a systematic meta-analysis显示文摘 | MAIDMENT I D FOX C G BOUSTANI M | 2008 | Ann Pharmacother2008，42，1： | 1 |
| 7 | A real-time particle filters显示文摘 | Kwok C Fox D Meil M | 2004 | Proceedings of the IEEE2004，92，3： | 1 |
| 8 | Mice lacking inducible nitric oxide synthase develop spontaneous hypercholestemlaemia and aortic atheromas显示文摘 | Ihrig M Dangler C A Fox J G | 2001 | Atherosclerosis2001，156，1： | 1 |
| 9 | Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans显示文摘 | Fox D S Cruz M C Sia R A L | 2001 | Molecular Microbiology2001，39，： | 1 |
| 10 | Fractal feature analysis and classification in medical imaging显示文摘 | CHEN Chi-chang Daponte J S Fox M D | 1989 | IEEE Transactions on Medical Imaging1989，8，2： | 1 |
| 11 | The serine/ threonine kinase Pim-2 is a transcriptionally regulated apopotot-ic inhibitor显示文摘 | FOX C J HAMMERMAN P S CINALLI R M | 2003 | Genes Dev2003，17，15： | 1 |
| 12 | Heterogeneous photocatalysis 显示文摘 | Fox M A Dulay M T | 1993 | Chem Rev1993，93，： | 1 |
| 13 | A requirement ontology for engineering design显示文摘 | LIN Jin-xin FOX M S BILGIC T | 1996 | Concurrent Engineering Research and Applications1996，4，3： | 1 |
| 14 | A function blocking abti-mouse integrin aipha5betal antibody inhibits angio- genesis and impedes tumor growth in vivo显示文摘 | Bhaskar V Zhang D Fox M | 2007 | J Transl Med2007，5，： | 1 |
| 15 | Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs 显示文摘 | Lalloo U Fox A Belvisi M | 1995 | J Appl Physiol1995，79，4： | 1 |
| 16 | A view of cloud computing显示文摘 | ARMBRUST M FOX A GRIFFITH R | 2010 | Communications of the ACM2010，53，4： | 1 |
| 17 | Recurrence of primary breast lymphoma in contralateral breast:case report and review of the literature显示文摘 | Earnest R E Downey D M Fox J P | | 0，，05： | 1 |
| 18 | Length of left main coronary artery显示文摘 | Fox C Davies M J Webb-Peploe M M | 1973 | Br Heart J1973，35，4： | 1 |
| 19 | Nuclear locali- zation of Myomesin-l: Possible functions显示文摘 | Reddy K B Fox J E Priee M G | 2008 | Muscle Res Cell Motil2008，29，1： | 1 |
| 20 | A view of cloud computing显示文摘 | Armbrust M Fox A Griffith R | 2010 | Communications of the ACM2010，53，4： | 1 |
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