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| 1 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 2 | NSAID use and dementia risk in the Cardiovascular Health Study*: Role of APOE and NSAID type显示文摘 | C A. Szekely J C.S. Breitner A L. Fitzpatrick T D. Rea B M. Psaty L H. Kuller P P. Zandi | 2008 | Neurology2008，，1： | 2 |
| 3 | Questionnaire on the perceptions of patients about shoulder surgery显示文摘 | Fitzpatrick R Carr A | 1996 | J Bone Joint Surg(Br)1996，78，： | 1 |
| 4 | The assessment of shoulder instability:the development and validation of a questionnaire显示文摘 | Fitzpatrick R Carr A | 1999 | J Bone Joint Surg(Br)1999，81，： | 1 |
| 5 | The London Millennium Footbridge 显示文摘 | Dallard P Fitzpatrick A J Flint A | 2001 | TheStructural Engineer2001，79，22： | 1 |
| 6 | MHC class Ⅱ expression in the bovine mammary gland显示文摘 | Fitzpatrick J L P J Cripps A W Hill | 1992 | Veterinary Immunology Immunopathology1992，32，： | 1 |
| 7 | Model ing water release and absorption in soils using cel ular automata显示文摘 | Aitkenhead M J Foster A R FitzPatrick E A | | 0，，220： | 1 |
| 8 | Crayfish molecular systematics: inferences using a combination of proce?dures to estimate phylogeny显示文摘 | Crandall K A Fitzpatrick J J R | 1996 | Syst Biol1996，45，1： | 1 |
| 9 | Measuring Clinical Nurse Performance:Development of the King's Nurse Per- formance Scale显示文摘 | Fitzpatrick J M While A E Roberts J D | 1997 | Int J Nurs Stud1997，34，3： | 1 |
| 10 | The Measurement of Nurse Performance and Its Differentiation by Course of Preparation显示文摘 | Fitzpatrick J M While A E Roberts J D | 1994 | J Adv Nurs1994，20，4： | 1 |
| 11 | Errors in parameter estimates from the force state mapping technique for free response due to phase distortion 显示文摘 | Meskell C Fitzpatrick J A | 2002 | Journal of Sound and Vibration2002，252，5： | 1 |
| 12 | Operationalisation of an Observation Instrument to Explore Nurse Performance 显示文摘 | Fitzpatrick J M While A E Roberts J D | 1996 | Int J Nurs Stud1996，33，4： | 1 |
| 13 | The London MillenniumFootbridge显示文摘 | Dallard P Fitzpatrick A J Flint A R | 2001 | Structural Engineer2001，7922，： | 1 |
| 14 | Emission of oxygenated species from the combustion of pine wood and its relation to soot formation 显示文摘 | Fitzpatrick E M Ross A B Bates J | 2007 | Process Safety Environ Prot2007，85，5： | 1 |
| 15 | Prospective study of alcohol consumption and risk of dementia in older adults显示文摘 | Mukamal K J Kuller L H Fitzpatrick A L | 2003 | JAMA2003，289，： | 1 |
| 16 | Review: Aeroacoustics research in Europe: The CEAS-ASC report on 2004 highlights显示文摘 | Fitzpatrick J A | 2005 | Journal of Sound and Vibration2005，288，： | 1 |
| 17 | Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins显示文摘 | Moos P J Edes K Fitzpatrick F A | 2000 | Proc Natl Acad Sci U S A2000，97，16： | 1 |
| 18 | The management and functional outcome of isolated burst fractures of the fifth lumbar vertebra显示文摘 | Butler J Fitzpatrick P Mhaolain A | | 0，，： | 1 |
| 19 | Climate change,plant migration,and range collapse in a global biodiversity hotspot:the Banksia (Proteaeeae) of Western Australia显示文摘 | Fitzpatrick M C Gove A D Sanders N J | 2008 | Global change biology2008，14，6： | 1 |
| 20 | Erythrocyte-neutrophil interaction: formation of leukotriene B4 by transcellular biosynthesis 显示文摘 | MCGEE J E FITZPATRICK F A | 1986 | Proc Natl Acad Sci USA1986，83，： | 1 |
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