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| 1 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003,,9: | 4 |
| 2 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003,,9: | 2 |
| 3 | 莱菔硫烷对头颈癌细胞系PCI-13中信号转导和转录激活因子1和3的影响显示文摘目的:研究莱菔硫烷(SFN)对头颈癌细胞系PCI-13中信号转导和转录激活因子1和3(STAT1,STAT3)的影响,探讨STAT/JAK途径在SFN抗肿瘤中的作用。方法:体外培养PCI-13细胞,经血清饥饿后,分别用0、10、20、40μmol/L的SFN处理3、6、12、24 h。为检测IL-6诱导的STAT3激活情况,用20、40μmol/L的SFN处理24 h,再用50 ng/ml的IL-6处理15min。设阴性和阳性对照组。分别获取细胞后,采用流式细胞术检测磷酸化-STAT(p-STAT)1和3的表达。结果:SFN对pSTAT1表达无影响,但可以显著抑制p-STAT3的表达,还可以抑制IL-6诱导的p-STAT3的升高,这种抑制存在浓度和时间依赖性。结论:SFN能够抑制PCI-13细胞中的STAT3的磷酸化水平,减少其构成性激活和IL-6诱导的激活,提示SFN诱导PCI-13细胞凋亡可能由STAT/JAK途径介导。 | 贾志宇 赵云转 王维丽 张英怀 Chweeming Lim Robert L Ferris | 2013 | 实用口腔医学杂志2013,29,6: | 2 |
| 4 | 舒尼替尼阻断STAT3通路抑制头颈鳞癌细胞PCI-13增殖显示文摘目的体外研究舒尼替尼对头颈鳞癌细胞系PCI-13增殖和凋亡的影响,并观察STAT1、STAT3在凋亡过程中的变化,探讨STAT3通路在舒尼替尼诱导肿瘤细胞凋亡中的作用。方法体外培养PCI-13细胞,用不同浓度的舒尼替尼处理24、48、72 h后,应用MTT比色实验,倒置显微镜、Wright-Giemsa染色、流式细胞术检测和观察PCI-13的生长抑制率和凋亡情况。细胞经血清饥饿后,分别用0、1、2、4μmol/L的舒尼替尼处理2、8、16和24 h,采用流式细胞术检测p-STAT1和3的表达,并设阴性和阳性对照组。结果舒尼替尼可明显抑制PCI-13细胞的增殖,其最高抑制率可达92%,各浓度用药组不同处理时间之间生长抑制率有显著差异(P<0.05),抑制率呈时间-浓度依赖性。同时舒尼替尼可诱导PCI-13细胞凋亡,凋亡率随处理时间延长和药物浓度增加而上升(P<0.05)。舒尼替尼不影响p-STAT1的表达(P>0.05),但是可以显著抑制p-STAT3的表达,这种抑制存在浓度依赖性(P<0.05)。结论舒尼替尼不但能够抑制PCI-13细胞增殖,诱导其凋亡,而且能够抑制PCI-13细胞中STAT3的磷酸化水平,减少其激活。提示舒尼替尼诱导PCI-13细胞凋亡可能由STAT/JAK途径介导。 | 贾志宇 赵云转 屈鹏飞 张英怀 Lim Chweeming Robert L Ferris | 2014 | 第三军医大学学报2014,36,1: | 2 |
| 5 | The Integrator complex controls the termination of transcription at diverse classes of gene targets显示文摘包含 INTS3 和 NABP1 或 NABP2 的建筑群开始在 DNA 损坏回答被描绘,但是他们的生物化学的功能仍然保持未知。用亲密关系纯化和 HIV 集成定序目标(HIT-Seq ) ,我们发现这些建筑群是综合者建筑群的部分,它绑 RNA 聚合酶 II 并且调整特定的目标基因。综合者作为他们在亲密地被结合的机制处理到他们的成熟形式的部分劈开 snRNAs 抄写结束。然而, HIT-Seq 表明那个综合者也绑在 3 ′以 polyadenylated 抄本复制依赖者 histones 和倡导者结束基因的近似区域。综合者子单元的弄空导致抄写结束失败, histone mRNA 处理的混乱,和 snRNAs 和 histone mRNAs 的 polyadenylation。而且,倡导者综合者的近似绑定否定地通常调整其抄本是的基因的表示 polyadenylated。到所有三个基因类的综合者招募是 DSIF 依赖的,建议那个综合者作为在 DSIF 依赖的 RNA 聚合酶 II 的结束建筑群工作暂停地点。 | Jeffrey R Skaar Andrea L Ferris Xiaolin Wu Anita Saraf Kum Kum Khanna Laurence Florens Michael P Washburn Stephen H Hughes Michele Pagano | 2015 | Cell Research2015,25,3: | 2 |
| 6 | SOX2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain显示文摘 | Ferri A L Cavallaro M Braida D | | 0,,15: | 2 |
| 7 | Clinical significance of mi- crometastases detection in lymph nodes from head and neck squamous ceil carcinoma 显示文摘 | Ferris R Xi L Raja S | 2008 | Otolaryngol Head Neck Surg2008,139,3: | 1 |
| 8 | Biomechanical consequences of plantar fascial release or rupture during gait: part Ⅰ -disruptions in longitudinal arch conformation 显示文摘 | Sharkey NA Ferris L Donahue SW | 1998 | Foot Ankle Int1998,19,: | 1 |
| 9 | Studying the Role of Political Competition in the Evolution of Government Size Over Long Horizons 显示文摘 | Ferris J S Park S P Winer S L | 2008 | Public Choice2008,,: | 1 |
| 10 | Strain and loading of the second metatarsal during heel lift 显示文摘 | Sharkey N A Ferris L Smith T S | 1995 | J Bone Joint Surg Am1995,77,7: | 1 |
| 11 | SIAM 显示文摘 | M C Ferris and O L Mangasarian Parallel Constraint Distribution | 1991 | Optimization1991,,: | 1 |
| 12 | Isolated microspore culture tech niques and recent progress for haploid and doubled haploid plant production 显示文摘 | Ferrie A MR Caswell K L | 2011 | Plant Cell Tissue and Organ Culture2011,104,3: | 1 |
| 13 | Rapid enumeration of respiratory viruses 显示文摘 | Ferris M M McCabe M O Doan L G | 2002 | Analytical Chemistry2002,74,8: | 1 |
| 14 | Differential ghost imaging显示文摘 | Ferri F Magatti D Lugiato L A | 2010 | Physical Review Letters2010,104,25: | 1 |
| 15 | Parallel variable distribution显示文摘 | Ferris M C Mangasarian O L | 1994 | SIAM Journal on Optimization1994,1,1: | 1 |
| 16 | Lymphoma of the ocular adnexa: A study of 353 cases显示文摘 | Ferry JA Fung CY Zukerberg L | 2007 | Am J Surg Pathol2007,31,2: | 1 |
| 17 | Intermittent oral ZD1839(Iressa), a novel epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI), shows evidence of good tolerability and activity:Final results from a phase I study显示文摘 | Ferry D Hammond L Ranson M | 2000 | Proc Am Soc Clin Oncol2000,19,: | 1 |
| 18 | 显示文摘 | Ferris V Goglio G Brohan L | 1997 | Mater Res Bull1997,32,: | 1 |
| 19 | Influence of talc physical properties on the fire retarding behaviour of (ethylenevinyl acetate copolymer/magnesium hydroxide/talc) composites显示文摘 | Clerc L Ferry L Leroy E | 2005 | Polymer Degradation and Stability2005,88,: | 1 |
| 20 | Red phos phorus/aluminum oxide compositions as flame retardants in recycled poly ( ethylene terephthalate) 显示文摘 | LAOUTID F FERRY L LOPEZ J M | 2003 | Polymer Degradation and Stability2003,82,2: | 1 |