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| 1 | LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells显示文摘LIN28 is an RNA binding protein with important roles in early embryo development,stem cell differentiation/re-programming,tumorigenesis and metabolism.Previous studies have focused mainly on its role in the cytosol where it interacts with Let-7 microRNA precursors or mRNAs,and few have addressed LIN28's role within the nucleus.Here,we show that LIN28 displays dynamic temporal and spatial expression during murine embryo development.Maternal LIN28 expression drops upon exit from the 2-cell stage,and zygotic LIN28 protein is induced at the forming nucleolus during 4-cell to blas-tocyst stage development,to become dominantly expressed in the cytosol after implantation.In cultured pluripotent stem cells(PSCs),loss of LIN28 led to nucleolar stress and activation of a 2-cell/4-cell-like transcriptional program characterized by the expression of endogenous retrovirus genes.Mechanistically,LIN28 binds to small nucleolar RNAs and rRNA to maintain nucleolar integrity,and its loss leads to nucleolar phase separation defects,ribosomal stress and activation of P53 which in turn binds to and activates 2C transcription factor Dux.LIN28 also resides in a complex containing the nucleolar factor Nucleolin(NCL)and the transcrip-tional repressor TRIM28,and LIN28 loss leads to reduced occupancy of the NCL/TRIM28 complex on the Dux and rDNA loci,and thus de-repressed Dux and reduced rRNA expression.Lin28 knockout cells with nucleolar stress are more likely to assume a slowly cycling,translationally inert and anabolically inactive state,which is a part of previously unappreciated 2C-like transcriptional program.These findings elucidate novel roles for nucleolar LIN28 in PSCs,and a new mechanism linking 2C program and nucleolar functions in PSCs and early embryo development. | Zhen Sun Hua Yu Jing Zhao Tianyu Tan Hongru Pan Yuqing Zhu Lang Chen Cheng Zhang Li Zhang Anhua Lei Yuyan Xu Xianju Bi Xin Huang Bo Gao Longfei Wang Cristina Correia Ming Chen Qiming Sun Yu Feng Li Shen Hao Wu Jianlong Wang Xiaohua Shen George Q.Daley Hu Li Jin Zhang | 2022 | Protein & Cell2022，13，7： | 4 |
| 2 | High performance liquid chromatographic separation of eight drugs collected in Chinese Pharmacopoeia 2010 on amylose ramification chiral stationary phase显示文摘The enantiomers separation of ei ght pharmaceutical racemates collected in Chinese Pharmacopoeia 2010(Ch.P2010),including nitrendipine,felodipine,omeprazole,praziquantel,sulpiride,clenbuterol hydrochloride,verapamil hydrochloride and chlorphenamine maleate,was performed on chiral stationary phase of amylose ramification by high performance liquid chromatography(HPLC)on Chiralpak AD-H column and Chiralpak AS-H column with the mobile phase consisted of isopropanol and n-hexane.The detection wavelength and the flow rate were set at 254 nm and 0.7 mL/min,respectively.The effects of proportion of organic additives,alcohol displacer and temperature on the separation were investigated.The results indicated that eight chiral drugs were separated on chiral stationary phase of amylase ramification in normal phase chroma tographic system.The chromatographic retention and resolution of enantiomers were adjusted by factors,including the changes of the concentration of alcohol displacer in mobile phase,organic alkaline modifier and column temperature.It was shown that the resolution was improved with reducing concentration of alcohol displacer.When the concentration of organic alkaline modifier was 0.2%,the resolution and the peak shape were fairly good.Most racemates mentioned above had the best resolution at column temperature of 25℃.The best temperature should be kept unchanged in the process of separation so as to obtain stable separation results. | Yan Wang Ying Zhou Chao Ma Beibei Yang Ru Feng Yiying Zhang Jie Fu Wenjing Chen Yupeng Sun Jingyi Ma Qiming Zhang Yulin Deng Yukui Zhang Wenyi He | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 3 |
| 3 | Preparation and characterization of amorphous silica nanowires from natural chrysotile显示文摘 | Kun Liu Qiming Feng Yanxia Yang Guofan Zhang Leming Ou Yiping Lu | 2007 | Journal of Non-Crystalline Solids2007，，16： | 2 |
| 4 | Study on washability of microcrystal graphite using float-sink tests显示文摘This article presented an experimental research on washability of microcrystal graphite using float-sink tests.Chemical and X-ray analyses showed that graphite,semi-graphite,meta-anthracite,and anthracite existed together in this microcrystal graphite sample;and the intergrowth relationship between microcrystal graphite and gangues was very complicated based on optical mineralogy research.The results of float-sink tests revealed that:for the-25+0.5 mm size fraction,about 68%(by weight)of microcrystal graphite was obtained at the density of 2.0 g/cm^3.and the float product met the standard of commercial grade W65;for the-0.5 mm size fraction,58%(by weight)of microcrystal graphite was floated at the density of 2.0 g/cm^3,which met the standard of commercial grade W70.It can be concluded that microcrystal graphite may be upgraded by dense media separation(DMS)providing a float product using as the raw materials of casting or refractories. | Li Hongqiang Feng Qiming Ou Leming Long Sisi Cui Mengmeng Weng Xiaoqing | 2013 | International Journal of Mining Science and Technology2013，23，6： | 2 |
| 5 | Sharkskin-Inspired Magnetoactive Reconfigurable Acoustic Metamaterials显示文摘Most of the existing acoustic metamaterials rely on architected structures with fixed configurations,and thus,their properties cannot be modulated once the structures are fabricated.Emerging active acoustic metamaterials highlight a promising opportunity to on-demand switch property states;however,they typically require tethered loads,such as mechanical compression or pneumatic actuation.Using untethered physical stimuli to actively switch property states of acoustic metamaterials remains largely unexplored.Here,inspired by the sharkskin denticles,we present a class of active acoustic metamaterials whose configurations can be on-demand switched via untethered magnetic fields,thus enabling active switching of acoustic transmission,wave guiding,logic operation,and reciprocity.The key mechanism relies on magnetically deformable Mie resonator pillar(MRP)arrays that can be tuned between vertical and bent states corresponding to the acoustic forbidding and conducting,respectively.The MRPs are made of a magnetoactive elastomer and feature wavy air channels to enable an artificial Mie resonance within a designed frequency regime.The Mie resonance induces an acoustic bandgap,which is closed when pillars are selectively bent by a sufficiently large magnetic field.These magnetoactive MRPs are further harnessed to design stimuli-controlled reconfigurable acoustic switches,logic gates,and diodes.Capable of creating the first generation of untethered-stimuli-induced active acoustic metadevices,the present paradigm may find broad engineering applications,ranging from noise control and audio modulation to sonic camouflage. | Kyung Hoon Lee Kunhao Yu Hasan Al Ba’ba’a An Xin Zhangzhengrong Feng Qiming Wang | 2020 | Research2020，，1： | 2 |
| 6 | An environmental-friendly technology of vanadium extraction from stone coal 显示文摘 | HE Dongsheng FENG Qiming ZHANG Guofan | 2007 | Minerals Engineering2007，20，11： | 1 |
| 7 | Solution Chemistry of Sodium Silicate and Implications for Pyrite Flotation显示文摘 | Feng Bo Lu Yiping Feng Qiming | 2012 | Industrial & Engineering Chemistry Research2012，51，12： | 1 |
| 8 | An environ- mentally-friendly technology of vanadium extraction from stone coal 显示文摘 | He Dongsheng Feng Qiming Zhang Guofan | 2007 | Minerals Engineering2007，20，2： | 1 |
| 9 | Polybrominated diphenyl ethers (PBDEs) in aquatic biota from the lower reach of the Yangtze River, East China显示文摘 | Zishen Gao Jie Xu Qiming Xian Jianfang Feng Xiaohui Chen Hongxia Yu | 2009 | Chemosphere2009，，9： | 1 |
| 10 | Separation of Pyrite from Chalcopyrite with Organic Depressant CTP, Transaction of Nonferrous Metals显示文摘 | Feng Qiming Ou Leming Lu Yiping | 1998 | Society of China1998，8，1： | 1 |
| 11 | An environmentally-friendly technology of vanadium extraction from stone coal显示文摘 | HE Dongsheng FENG Qiming ZHANG Guofan | 2007 | Minerals Engineering2007，20，： | 1 |
| 12 | Spontaneous intracerebral hemorrhage in CADASIL显示文摘 | Lifei Lian Dujuan Li Zheng Xue Qiming Liang Feng Xu Huicong Kang Xiaoyan Liu Suiqiang Zhu | 2013 | The Journal of Headache and Pain2013，，1： | 1 |
| 13 | An environmen- tally-friendly technology of vanadium extraction from stone coal 显示文摘 | He Dongsheng Feng Qiming Zhang Guofan | 2007 | Minerals Engineering2007，，12： | 1 |
| 14 | Novel transparent and flexible nanocomposite film prepared from chrysotile nanofibres显示文摘 | Kun Liu Binnan Zhu Qiming Feng Tao Duan | 2013 | Materials Chemistry and Physics2013，，1： | 1 |
| 15 | The effect of PAX/CMC addition order on chlorite/pyrite separation显示文摘 | Bo Feng Qiming Feng Yiping Lu Yanling Gu | 2013 | Minerals Engineering2013，，： | 1 |
| 16 | An environmentally-friendly technology of vanadium extraction from stone coal显示文摘 | Dongsheng He Qiming Feng Guofan Zhang Leming Ou Yiping Lu | 2007 | Minerals Engineering2007，，12： | 1 |
| 17 | Prediction of Edge Level of Semiconductor Mineral by Means of Zeta Potential显示文摘 | Chen Jianhua Feng Qiming Lu Yiping | 2000 | Transactions of Nonferrous Metals Society of China2000，10，： | 1 |
| 18 | THE PULP ELECTROCHEMISTRY OF FLOTATION SEPARATION FOR STIBNITE-ARSENOPYRITE BULK CONCENTRATE显示文摘THEPULPELECTROCHEMISTRYOFFLOTATIONSEPARATIONFORSTIBNITE-ARSENOPYRITEBULKCONCENTRATEOuLemingFengQimingChenJin(DepartmentofMine... | Ou Leming Feng Qiming Chen Jin(Department of Mineral Engineering, Central South University of Technology, Changsha 410083,China) | 1998 | Journal of Central South University1998，10，1： | 1 |
| 19 | A review of tobacco smoking and smoking cessation practices among physicians in China: 1987 - 2010 显示文摘 | Abu Abdullah Feng Qiming Vivian Pun | 2011 | Tobacco control2011，20，1： | 1 |
| 20 | Schottky emission at the metal polymer interface and its effect on the polarization switching of ferroelectric poly(vinylidene fluoride trifluoroethylene) copolymer thin films 显示文摘 | Xia Feng Zhang Qiming | 2004 | Applied Physics Letters2004，85，10： | 1 |
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