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| 1 | Effect of drug treatment on hyperplastic gastric polyps infected with Helicobacter pylorh A randomized, controlled trial显示文摘瞄准:为了学习,增生的胃的息肉上的药物疗法的效果与 Helicobacter 感染了 pylori (H pylori ) 。方法:有感染 H pylori 的增生的胃的息肉(在直径的 3-10 公里)的 48 个病人随机被分到一个治疗组( n = 24 )它收到了质子泵禁止者( omeprazole 或 lansoprazole ), clarithromycin ,枸橼酸铋和 tinidazole ,并且控制组织( n = 24 )它收到了胃粘膜( tepretone )的保护的代理人。病人们在注册和 1-12 瞬间术后疗法前定期经历了内视镜检查法和 H pylori 检查。结果:在治疗的 22 个病人组织, 21 在控制组织完成了全部测试协议。在治疗组,息肉消失了 1-12 瞬间(平均, 6.5+/-1.1 瞬间) 在在 22 中的 15 个的治疗以后,病人(68.2%) 和 H pylori 感染在 22 个病人(86.4%) 中的 19 个被根除。然而,在学习,在息肉的没有变化或 H pylori 地位以后的 12 个月在任何控制((b) P<0.01 ) 被看见。结论:最增生的胃的息肉消失在 H pylori 的根除以后。 | Feng Ji Zi-Wei Wang Jian-Wen Ning Qun-Yan Wang Jian-Yong Chen You-Ming Li | 2006 | World Journal of Gastroenterology2006，12，11： | 38 |
| 2 | A COUNTER PROPAGATING WAVE STATE WITH A PERIODICALLY HORIZONTAL MOTION OF DEFECTS显示文摘Convection in a horizontal fluid layer heated from below is one of models for studying patterns of convection in binary fluid mixtures and has been extensively studied. In this article, the convection structures in a rectangular cell were investigated for the aspect-ratio Γ =12 and the separation ratio ψ = -0 .47. Simulations were preformed by solving the hydrodynamic equations using the SIMPLE method. A Counter Propagating Wave (CPW) state was found in binary fluid convection with a periodically horizontal motion of defects, and the pattern dynamics was further discuss. | NING Li-zhong QI Xin YUAN Zhe SHI Feng | 2008 | Journal of Hydrodynamics2008，20，5： | 40 |
| 3 | Chinese medicines for prevention and treatment of human hepatocellular carcinoma: current progress on pharmacological actions and mechanisms显示文摘Hepatocellular carcinoma(HCC) is one of leading causes of death in the world. Although various treatments have been developed, the therapeutic side effects are far from desirable. Chinese medicines(CMs, including plants, animal parts and minerals) have drawn a great deal of attention in recent years for their potential in the treatment of HCC. Most studies have shown that CMs may be able to retard HCC progression with multiple actions, either alone or in combination with other conventional therapies to improve quality of life in HCC patients. Additionally, CMs are used for preventing HCC occurrence. The aim of this study is to review the potential prophylactic and curative effects of CMs on human HCC and the possible mechanisms that underlie these pharmacological actions. Publications were collected and reviewed from Pub Med and China National Knowledge Infrastructure from 2000 to 2014. Keywords for literature searches include 'Chinese medicine', 'Chinese herb', 'traditional Chinese Medicine', 'hepatocellular carcinoma' and 'liver cancer'. CMs in forms of pure compounds, isolated fractions, and composite formulas are included. Combination therapies are also considered. Both in vitro and in vivo efficacies of CMs are being discussed and the translational potential to bedside is to be discussed with clinical cases, which show the actions of CMs on HCC may include tumor growth inhibition, antimetastatic activities, anti-inflammation, anti-liver cancer stem cells, reversal on multi-drug resistance and induction/reduction of oxidative stress. Multiple types of molecules are found to contribute in the above actions. The review paper indicated that CMs might have potential to both prevent HCC occurrence and retard HCC progression with several molecular targets involved. | Xuanbin Wang Ning Wang Fan Cheung Lixing Lao Charlie Li Yibin Feng | 2015 | Journal of Integrative Medicine2015，13，3： | 33 |
| 4 | Modeling sustainability:population,inequality,consumption,and bidirectional coupling of the Earth and Human Systems显示文摘Over the last two centuries,the impact of the Human System has grown dramatically,becoming strongly dominant within the Earth System in many diferent ways.Consumption,inequality,and population have increased extremely fast,especially since about 1950,threatening to overwhelm the many critical functions and ecosystems of the Earth System.Changes in the Earth System,in turn,have important feedback efects on the Human System,with costly and potentially serious consequences.However,current models do not incorporate these critical feedbacks.We argue that in order to understand the dynamics of either system,Earth System Models must be coupled with Human System Models through bidirectional couplings representing the positive,negative,and delayed feedbacks that exist in the real systems.In particular,key Human System variables,such as demographics,inequality,economic growth,and migration,are not coupled with the Earth System but are instead driven by exogenous estimates,such as United Nations population projections.his makes current models likely to miss important feedbacks in the real Earth–Human system,especially those that may result in unexpected or counterintuitive outcomes,and thus requiring diferent policy interventions from current models.he importance and imminence of sustainability challenges,the dominant role of the Human System in the Earth System,and the essential roles the Earth System plays for the Human System,all call for collaboration of natural scientists,social scientists,and engineers in multidisciplinary research and modeling to develop coupled Earth–Human system models for devising efective science-based policies and measures to beneit current and future generations. | Safa Motesharrei Jorge Rivas Eugenia Kalnay Ghassem R.Asrar Antonio J.Busalacchi Robert F.Cahalan Mark A.Cane Rita R.Colwell Kuishuang Feng Rachel S.Franklin Klaus Hubacek Fernando Miralles-Wilhelm Takemasa Miyoshi Matthias Ruth Roald Sagdeev Adel Shirmohammadi Jagadish Shukla Jelena Srebric Victor M.Yakovenko Ning Zeng | 2016 | National Science Review2016，3，4： | 34 |
| 5 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 6 | Electrophysiological effects of Chinese medicine Shen song Yang xin (SSYX) on Chinese miniature swine heart and isolated guinea pig ventricular myocytes显示文摘背景沈歌杨 xin (SSYX ) 是有增加心率(HR ) 的效果的中国药的混合物。这研究试图在心和细胞的层次评估它的 electrophysiological 性质。中国缩小的猪随机被分到二个组的方法,与 SSYX 或安慰剂管理了 4 个星期(n=8 每组) 。心脏的 electrophysiological 学习(EPS ) 在药管理前后被执行。畿尼猪室的 myocytes 酶地被孤立,整个房间电压夹钳技术被用来在心脏的行动潜力(AP ) 上评估 SSYX 的效果。结果 SSYX 处理加速了 HR 从(141. | FENG Li GONG Jing JIN Zhen-yi LI Ning SUN Li-ping WU Yi-ling PU Jie-lin | 2009 | Chinese Medical Journal2009，，13： | 28 |
| 7 | The willow genome and divergent evolution from poplar after the common genome duplication显示文摘 | Xiaogang Dai Quanjun Hu Qingle Cai Kai Feng Ning Ye Gerald A Tuskan Richard Milne Yingnan Chen Zhibing Wan Zefu Wang Wenchun Luo Kun Wang Dongshi Wan Mingxiu Wang Jun Wang Jianquan Liu Tongming Yin | 2014 | Cell Research2014，24，10： | 28 |
| 8 | Fairness-Oriented Hybrid Precoding for Massive MIMO Maritime Downlink Systems with Large-Scale CSIT显示文摘Different from conventional cellular networks, a maritime communication base station(BS) has to cover a much wider area due to the limitation of available BS sites. Accordingly the performance of users far away from the BS is poor in general. This renders the fairness among users a challenging issue for maritime communications. In this paper, we consider a practical massive MIMO maritime BS with hybrid digital and analog precoding. Only the large-scale channel state information at the transmitter(CSIT) is considered so as to reduce the implementation complexity and overhead of the system. On this basis, we address the problem of fairness-oriented precoding design. A max-min optimization problem is formulated and solved in an iterative way. Simulation results demonstrate that the proposed scheme performs much better than conventional hybrid precoding algorithms in terms of minimum achievable rate of all the users, for the typical three-ray maritime channel model. | Chengxiao Liu Wei Feng Te Wei Ning Ge | 2018 | China Communications2018，15，1： | 23 |
| 9 | Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle显示文摘在到最糟的最高的注意在航线上吸烟以及薄雾侮辱的全球付钱的时间,所有人知道两个外长、显著。然而,包括许多医药人员,人们主要不知道 gastroesophageal 倒流(GER ) 怎么糟糕在我们的自己的航线上侮辱。GER 的症状通常被看作心痛和流回,它能主要被容忍。不管多么起来在它出现的地方,去的胃的内容相对地传递食管然后远侧的咽象苛评一样的鸟喙,用作一张嘴,以便生产众多微粒子并且到达oro鼻的洞并且另外引起的航线过敏鼻炎和气喘的攻击,甚至肺的实质损害。它将减少生活质量或甚至使受危险生活。内长的侮辱在呼吸系统出现,但是从消化的道发源的点不是众所周知的并且经常 undiagnosed 并且不正确地对待。导致的航线挑战是的 GER 一个可对待、预防的实体一旦诊断被做,好消除能通过 radiofrequency 或 fundoplication 借助于张开的贲门的生活方式调整,药,或固定被期望。作者王忠高博士承受了它为长并且症状在反倒流外科以后消失了 8 年。这是王忠高博士和他的队工作的一个演讲并且将引起注意到公众以便认出作为吸烟或薄雾从人的本身,然而并非从外面的环境发生的一个可对待的条件做的这个相对未知的实体。 | Zhonggao Wang Zhiwei Hu Jimin Wu Feng Ji Hongtao Wang Yungang Lai Xiang Gao Yachan Ning Chengchao Zhang Zhitong Li Weitao Liang Jianjun Liu | 2015 | Frontiers of Medicine2015，9，1： | 21 |
| 10 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 11 | Radiofrequency treatment on respiratory symptoms due to gastroesophageal reflux disease显示文摘为 gastroesophageal 倒流疾病(GERD ) 的呼吸症状(RS ) 的背景诊断和治疗对普通食道的症状比那更困难。这研究的目标是评估 radiofrequency (RF ) 的功效和安全在到有象喘那样的主要呼吸的演讲的 10 月 2008,505 日 GERD 病人的从 2006 年 4 月的初步的 12 月的后续 observation.Methods 的 GERD 的 RS 上的治疗,长期的咳嗽或嘶哑,被内视镜的 RF 对待。一张问询表在治疗前后被完成,用从 0 ~ 5 估计症状严厉和频率的六点的规模。症状分数是频率的和, severity.Results 症状分数显著地在后续经期的结束被改进。吝啬的心痛分数从 5.31 ~ 1.79 减少了。吝啬的流回分数从 5.02 ~ 1.64 减少了;吝啬的咳嗽分数从 6.77 ~ 2.85 减少了;吝啬的喘分数从 7.83 ~ 3.07 减少了;并且吝啬的嘶哑分数从 5.13 ~ 1.81 减少了(P 0.01 ) 。没有主要复杂并发症或死亡发生了。次要的复杂并发症包括了暂时的 procedural 以后 retrosternal 不舒适或疼痛(n=106; 21.0%) ,温和发烧(n=86; 17.0%) ,短暂恶心 / 呕吐(n=97; 19.2%) ,并且短暂咽下困难(n=42; 9.3%) 。35 (6.9%) 病人们有症状的复发。内视镜的 RF 治疗在六个病人被重复,并且 laparoscopic fundoplication 在内视镜的 RF 是的 seven.Conclusion 被执行与 GERD 在病人对待 RS 的一个有效、安全的工具。 | GAO Xiang WANG Zhong-gao WU Ji-min JI Feng ZHANG Cheng-chao NING Ya-chan LI Zhi-tong HU Zhi-wei CHEN Xiu TIAN Shu-rui | 2011 | Chinese Medical Journal2011，，7： | 19 |
| 12 | Emodin, an 11β-hydroxysteroid dehydrogenase type I inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice显示文摘 | Yue-jing WANG Su-ling HUANG Ying FENG Meng-meng NING Ying LENG | 2012 | Acta Pharmacologica Sinica2012，33，9： | 19 |
| 13 | Histological Subtypes of Lung Cancer in Chinese Males from 2000 to 2012显示文摘Objective To characterize the histological and epidemiological features of male lung cancer patients in China. Methods The demographic and histological information about male lung cancer patients identified from 2000-01-01 to 2012-12-31,was collected from the Cancer Hospital of the Chinese Academy of Medical Sciences. Relative frequencies(RF) were estimated for major histological subtypes and compared according to the years of diagnosis and birth. Results The RF of adenocarcinoma(ADC) increased from 21.96% to 43.36% and the RF of squamous cell carcinoma(SCC) decreased from 39.11% to 32.23% from 2000 to 2012 in the 15 427 male lung cancer patients included in this study(Z=17.909,P<0.0001; Z=-6.117,P<0.0001). The RF of ADC increased from 28.72% in 2000-2004,36.88% in 2005-2008 to 48.61% in 2009-2012 in patients born after 1960. The age-adjusted RF of ADC in 2007-2012 increased consistently in all the investigated areas. Conclusion The increased RF of ADC in male lung cancer patients highlights the need for further investigation of the etiologic factors of these tumors. Smoke-free policies rather than modifying tobacco products should be enforced. | ZOU Xiao Nong LIN Dong Mei WAN Xia CHAO Ann FENG Qin Fu DAI Zhen YANG Gong Huan LV Ning | 2014 | Biomedical and Environmental Sciences2014，27，1： | 19 |
| 14 | Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease显示文摘煽动性的肠疾病(IBD ) 是包括中国在亚洲增加的流行的世界范围的肠的免疫者不正常的疾病。它是有未知原因的胃肠的道的长期的疾病。Exosomes 是在各种各样的身体液体的小泡。他们有 40-120 的直径 ? nm,并且他们的功能之一是各种各样的物质的长途的转移。在这研究,我们与 IBD 并且在健康控制在病人调查了唾液的 exosomes 的内容与 IBD 在病人探索新 biomarker。在这研究,整个口水与 IBD 从病人被获得(ulcerative 大肠炎(UC ) , n ?=? 37;Crohns 疾病(CD ) , n ?=? 11 ) 并且显然健康的个人(HC, n ?=? 10 ) 。唾液的 exosomes 从样品被提取,并且在 exosomes 以内的蛋白质被液体用色层法分离团分光计(LC-MS/MS ) 识别。结果证明超过 2000 蛋白质与 IBD 从病人在唾液的 exosomes 被检测。通过基因本体论分析,我们发现(PSMA7 ) proteasome 子单元 alpha 类型 7 与 IBD 和健康控制显示出病人之间的特别显著的差别,因为它的表达式水平在 CD 和 UC 组是高得多的。这 exosomal 蛋白质与 proteasome 活动和煽动性的回答有关。我们因此断定在这研究,唾液的 exosomal PSMA7 在在从有 IBD 的题目的唾液的 exosomes 的高水平是在场的。免除病人 colonoscopy 的疼痛能是很有希望的 biomarker。 | Xiaowen Zheng Feng Chen Qian Zhang Yulan Liu Peng You Shan Sun Jiuxiang Lin Ning Chen | 2017 | Protein & Cell2017，8，9： | 19 |
| 15 | Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4显示文摘Our previous studies showed that ferroptosis plays an important role in the acute and subacute stages of spinal cord injury.High intracellular iron levels and low glutathione levels make oligodendrocytes vulnerable to cell death after central nervous system trauma.In this study,we established an oligodendrocyte(OLN-93 cell line)model of ferroptosis induced by RSL-3,an inhibitor of glutathione peroxidase 4(GPX4).RSL-3 significantly increased intracellular concentrations of reactive oxygen species and malondialdehyde.RSL-3 also inhibited the main antiferroptosis pathway,i.e.,SLC7A11/glutathione/glutathione peroxidase 4(xCT/GSH/GPX4),and downregulated acyl-coenzyme A synthetase long chain family member 4.Furthermore,we evaluated the ability of several compounds to rescue oligodendrocytes from ferroptosis.Liproxstatin-1 was more potent than edaravone or deferoxamine.Liproxstatin-1 not only inhibited mitochondrial lipid peroxidation,but also restored the expression of GSH,GPX4 and ferroptosis suppressor protein 1.These findings suggest that GPX4 inhibition induces ferroptosis in oligodendrocytes,and that liproxstatin-1 is a potent inhibitor of ferroptosis.Therefore,liproxstatin-1 may be a promising drug for the treatment of central nervous system diseases. | Bao-You Fan Yi-Lin Pang Wen-Xiang Li Chen-Xi Zhao Yan Zhang Xu Wang Guang-Zhi Ning Xiao-Hong Kong Chang Liu Xue Yao Shi-Qing Feng | 2021 | Neural Regeneration Research2021，16，3： | 19 |
| 16 | miR-27b inhibits gastric cancer metastasis by targeting NR2F2显示文摘增加的注意在癌症过程集中于 miRNAs 的下面规定。原子受体亚科 2 (NR2F2,也作为 COUP-TFII 知道) 涉及癌症的许多类型的发展,但是它在胃的癌症的角色留下逃犯。在这个实验, oncomine 和 Kaplan-meier 数据库表明 NR2F2 在胃的癌症是起来调整的并且高 NR2F2 表示贡献了差的幸存。MicroRNA-27b 被指向并且由在人的胃的癌症纸巾和房间的 NR2F2 下面调整。miR-27b 的宫外的表示在 vitro 并且在 vivo 禁止了胃的癌症房间增长和肿瘤生长。试金建议 miR-27b 的 overexpression 能支持 MGC-803 房间移植和侵略并且延迟他们的转移到肝。另外, miR-27b 的下面规定在 vitro 提高了 GES-1 房间增长和转移。这些调查结果表明 miR-27b 为改进病人是在胃的癌症和 biomarker 的肿瘤 suppressor 幸存。 | Qingzhao Feng Xionglin Wu Fuchao Li Beibei Ning Xiaofeng Lu Yin Zhang Ying Pan Wenxian Guan | 2017 | Protein & Cell2017，8，2： | 16 |
| 17 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 18 | Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition显示文摘BACKGROUND:Emodin,a traditional Chinese medicine,has a therapeutic effect on severe acute pancreatitis(SAP),whereas the underlying mechanism is still unclear.Studies showed that the intestinal mucosa impairment,and subsequent release of endotoxin and proinflammatory cytokines such as IL-1β,which further leads to the dysfunction of multiple organs,is the potentially lethal mechanism of SAP.Caspase-1,an IL-1β-converting enzyme,plays an important role in this cytokine cascade process.Investigation of the effect of emodin on regulating the caspase-1 expression and the release proinflammatory cytokines will help to reveal mechanism of emodin in treating SAP.METHODS:Eighty Sprague-Dawley rats were randomly divided into four groups(n=20 each group):SAP,sham-operated(SO),emodin-treated(EM) and caspase-1 inhibitor-treated(ICE-I) groups.SAP was induced by retrograde infusion of 3.5% sodium taurocholate into the pancreatic duct.Emodin and caspase-1 inhibitor were given 30 minutes before and 12 hours after SAP induction.Serum levels of IL-1β,IL-18 and endotoxin,histopathological alteration of pancreas tissues,intestinal mucosa,and the intestinal caspase-1 m RNA and protein expressions were assessed 24 hours after SAP induction.RESULTS:Rats in the SAP group had higher serum levels of IL-1β and IL-18(P<0.05),pancreatic and gut pathological scores(P<0.05),and caspase-1 m RNA and protein expressions(P<0.05) compared with the SO group.Compared with the SAP group,rats in the EM and ICE-I groups had lower IL-1β and IL-18 levels(P<0.05),lower pancreatic and gut pathological scores(P<0.05),and decreased expression of intestine caspase-1 m RNA(P<0.05).Ultrastructural analysis by transmission electron microscopy found that rats in the SAP group had vaguer epithelial junctions,more disappeared intercellular joints,and more damaged intracellular organelles compared with those in the SO group or the EM and ICE-I groups.CONCLUSIONS:Emodin alleviated pancreatic and intestinal mucosa injury in experimental SAP.Its mechanism may partly be mediated by the inhibition of caspase-1 and its downstream inflammatory cytokines,including IL-1β and IL-18.Our animal data may be applicable in clinical practice. | Jian-Wen Ning Yan Zhang Mo-Sang Yu Meng-Li Gu Jia Xu Ali Usman Feng Ji | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，4： | 15 |
| 19 | Modeling the global ionospheric total electron content with empirical orthogonal function analysis显示文摘In the present work we model the global ionospheric total electron content (TEC) with the analysis of empirical orthogonal functions (EOF). The obtained statistical eigen modes, which makeup the modeled TEC, consist of two factors: the eigen vectors mapping TEC patterns at latitude and longitude (or local time LT), and the corresponding coefficients displaying the TEC variations in different time scales, i.e., the solar cycle, the yearly (annual and semiannual) and the diurnal universal time variations. It is found that the EOF analysis can separate the TEC variations into chief processes and the first two modes illustrate the most of the ionospheric climate properties. The first mode contains both the semiannual component which shows the semiannual ionospheric anomaly and the annual component which shows the annual or non-seasonal ionospheric anomaly. The second mode contains mainly the annual component and shows the normal seasonal ionospheric variation at most latitudes and local time sectors. The annual component in the second mode also manifests seasonal anomaly of the ionosphere at higher mid-latitudes around noontime. It is concluded that the EOF analysis, as a statistical eigen mode method, is resultful in analyzing the ionospheric climatology hence can be used to construct the empirical model for the ionospheric climatology. | WAN WeiXing DING Feng REN ZhiPeng ZHANG ManLian LIU LiBo NING BaiQi | 2012 | Science China(Technological Sciences)2012，55，5： | 15 |
| 20 | Staged carotid artery angioplasty and stenting for patients with high-grade carotid stenosis with high risk of developing hyperperfusion injury:a retrospective analysis of 44 cases显示文摘Background:Hyperperfusion syndrome(HPS)is a rare but potentially a life-threatening complication after carotid artery angioplasty and stenting(CAS).Staged CAS has been an alternative to prevent HPS.Materials and methods:44 of 908 patients with high-grade internal carotid artery stenosis or near occlusion were at risk of HPS because of poor collateral flow and impaired cerebral blood flow(CBF).They were treated with first(stage 1),followed by a full CAS(stage 2)1 month later.Their 30-day outcomes were tabulated and analysed.Results:During follow-up,1 of the 44(2.2%)patients developed HPS immediately,3(7%)had postprocedural HPS(ie,transcranial Doppler(TCD)>120%)without clinical symptoms and 3(7%)required stenting at stage 1 for carotid dissections.After stage 1,there were significant improvement between the preprocedural and postprocedural CBF(0.98±0.06 vs 0.85±0.05,p<0.05),mean transit time(MTT;1.05±0.05 vs 1.15±0.05,p<0.05),time to peak(TTP;1.04±0.06 vs 1.20±0.06,p<0.05)on CT perfusion(CTP),and CBF(66.41±7.41 vs 44.44±6.43,p<0.05)on TCD.After stage 2,improvement was seen in CBF(1.01±0.07 vs 0.98±0.06,p<0.05),MTT(1.01±0.05 vs 1.05±0.05,p<0.05),TTP(0.99±0.06 vs 1.04±0.06,p<0.05)on CTP and CBF(66.41±7.41 vs 93.78±18.81,p<0.05)on TCD.2 had postoperative increase of middle cerebral artery mean flow velocity of 120%after stage 2 without clinical symptoms.Conclusion:Staged carotid artery stenting probably decreased the chance of developing HPS in this group of selected patients.Although requiring a 2-step intervention,staged CAS may be a safe and effective alternative. | Dapeng Mo Gang Luo Bo Wang Ning Ma Feng Gao Xuan Sun Xiaotong Xu Zhongrong Miao | 2016 | Stroke & Vascular Neurology2016，1，4： | 14 |
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