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| 1 | Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarclnoma显示文摘有证据建议那刺激滤泡的荷尔蒙(FSH ) 能由在癌症细胞增加脉管的 endothelial 生长因素(VEGF ) 表示便于卵巢的癌症的 neovascularization,尽管这个过程的内在的分子的机制不是众所周知的。因此,我们在卵巢的癌症房间线 SKOV-3 和 ES-2 在 VEGF 表示上调查了 FSH 的效果。有 FSH 的治疗显著地在一个剂量依赖者和时间依赖者举止增加了 VEGF 表示。另外, FSH 治疗提高了 survivin 和组织缺氧可诱导的 factor-1 (HIF-1 ) 的表示。survivin 或 HIF-1 击倒压制的 VEGF 表示,但是 survivin 仅仅击倒禁止的刺激 FSH 的 VEGF 表示。有 LY294002 的预告的处理,一个 phosphoinositide 3-kinase (PI3K )/AKT 禁止者,抵销 FSH,而是治疗与 U0126 导致的 survivin 的提高的表示,激活 mitogen 的蛋白质 kinase/extracellular 调整信号的 kinase 禁止者,没有如此的效果。我们进一步证明卵巢的浆液的 cystadenocarcinoma 样品有积极 AKT 和比的染色的 phosphorylated AKT (pAKT ) 蛋白质的许多更高的发生良性的卵巢的 cystadenoma 取样了(p < 0.01 ) 。5 年的幸存率仅仅在有卵巢的浆液的 cystadenocarcinoma 的病人是大约 15% 有 AKT 和 pAKT 表示,而它在没有 AKT 或 pAKT 表示的那些是大约 80% 。一起拿,这些结果显示 FSH 由 upregulating 增加 VEGF 的表示 survivin 的表示,它被发信号的 PI3K/AKT 激活小径。在 survivin 和 VEGF 的刺激 FSH 的表示理解 PI3K/AKT 小径的角色将为与卵巢的浆液的 cystadenocarcinoma 为病人评估预后并且为对这疾病追求有效治疗是有益的。 | Yan Huang Keqin Hua Xianrong Zhou Hongyan Jin Xiaojun Chen Xin Lu Yinhua Yu Xiliang Zha Youji Feng | 2008 | Cell Research2008，18，7： | 17 |
| 2 | 电场作用下压坯密度对Fe-Ti-C体系低温燃烧合成的影响显示文摘采用Gleeble-1500D热模拟机,在电场和大热流密度作用下,研究压坯密度对55%(Ti+C)-45%Fe(质量分数)粉末压坯低温燃烧合成过程的影响.结果表明:当压坯密度在68%~78%范围内,体系的点火温度在340℃~650℃之间;随压坯密度提高,体系点火温度降低,点火延迟时间缩短,所达到的最高温度也降低.同时,合成产物的XRD结果表明:较低密度压坯的合成反应进行完全,而过高的压坯密度会导致合成反应的不完全性. | Feng Keqin 杨屹 沈保罗 林慧敏 何洪 | 2005 | 稀有金属材料与工程2005，34，3： | 13 |
| 3 | Joint utilization of genetic analysis and semi-cloning technology reveals a digenic etiology of Müllerian anomalies显示文摘Dear Editor,Identifying pathogenic gene mutations and their combination is critical but challenging in dissecting the etiology of complex diseases when more than one gene is involved.1 The digenic/oligogenic/omnigenic models,holding that more than one gene could act synergistically,appeal to a wide range of genes responsible for complex phenotypes.1,2,3,4 These genetic models advanced our understanding of genetic factors underlying complex phenotypes,yet an accordingly rapid and efficient experimental assay for identifying pathogenic combinations of genetic variants at animal model level is lacking and urgently needed. | Lingbo Wang Ying Zhang Xiaoyi Fu Shuangshuang Dong Shuyan Tang Ning Zhang Chengcheng Song Nan Yang Lin Zhang Hongyan Wang Huijuan Shi Li Jin Feng Zhang Jinsong Li Keqin Hua | 2020 | Cell Research2020，30，1： | 8 |
| 4 | Strain Transfer Mechanism of Grating Ends Fiber Bragg Grating for Structural Health Monitoring显示文摘The grating ends bonding fiber Bragg grating(FBG)sensor has been widely used in sensor packages such as substrate type and clamp type for health monitoring of large structures.However,owing to the shear deformation of the adhesive layer of FBG,the strain measured by FBG is often different from the strain of actual matrix,which causes strain measurement errors.This investigation aims at improving the measurement accuracy of strain for the grating ends surface-bonded FBG.To fulfill this objective,a strain transfer equation of the grating ends bonding FBG is derived,and a theoretical model of the average strain transfer from the matrix to the optical fiber is developed.Moreover,parameters that influence the average strain transfer rate from the matrix to the optical fiber are analyzed.A selection scheme of bonding parameters by numerical simulation is provided,which is significantly advantageous over that of the grating bonding FBG.The theoretical equation is verified by finite element method(FEM).Compared with the existing model,the proposed model has higher measurement accuracy.Experimental tests are performed to validate the effectiveness of the proposed model on the equalintensity cantilever beam,whose surface is attached to the bare FBG with grating ends bonding and strain gauge by using epoxy glue.The results show that there is a great agreement between the outcome of the bare FBG and that of the strain gauge,and the corrected strain is closer to the true strain.The proposed model provides a theoretical basis for the design of the grating ends surface-bonded FBG strain sensor for health monitoring of large structures. | Guang Chen Keqin Ding Qibo Feng Xinran Yin Fangxiong Tang | 2019 | Structural Durability & Health Monitoring2019，13，3： | 4 |
| 5 | Constructions on Approximately Mutually Unbiased Bases by Galois Rings显示文摘Several new series of approximately mutually unbiased bases are constructed by using Gauss sums and Jacobi sums over Galois rings GR(p2, r), and the tensor method. | LI Jin FENG Keqin | 2015 | Journal of Systems Science & Complexity2015，28，6： | 3 |
| 6 | ON THE COMPLEXITY OF THE NORMAL BASES VIA PRIME GAUSS PERIOD OVER FINITE FIELDS显示文摘A formula on the complexity of the normal bases generated by prime Gauss period overfinite fields is presented in terms of cyclotomic numbers.Then,the authors determine explicitly thecomplexity of such normal bases and their dual bases in several cases where the related cyclotomicnumbers have been calculated.Particularly,the authors find several series of such normal bases withlow complexity. | Qunying LIAO Keqin FENG | 2009 | Journal of Systems Science & Complexity2009，22，3： | 2 |
| 7 | On aperiodic and periodic complementary sequences显示文摘 | FENG KEQIN SHIUE P J XIANG Q | 1999 | IEEE Trans Inform Theory1999，45，1： | 1 |
| 8 | In situ synthesis of TiC/Fe composites by reaction casting显示文摘 | FENG Keqin YANG Yi SHEN Baoluo | 2005 | Materials & Design2005，26，1： | 1 |
| 9 | Intensified sintering of iron powders under the action of an electric field: Effect of technologic parameter on sintering densification 显示文摘 | Keqin Feng Yi Yang Mei Hong | 2008 | Material Processing Technology2008，20，8： | 1 |
| 10 | Value distributions of exponential sums from perfect nonlinear functions and their applications显示文摘 | FENG Keqin Luo Jinquan | 2007 | IEEE Transactions on Information Theory2007，53，9： | 1 |
| 11 | Generalized bent functions and class group of imaginary quadratic fields显示文摘 | Keqin Feng | 2001 | Science in China Series A: Mathematics2001，，5： | 1 |
| 12 | Constructing Symmetric Boolean Functions with Maximum Algebraic Immunity显示文摘 | Qu kongjiang Feng Keqin Liu Feng | 2009 | IEEE Transactions on Information Theory2009，55，5： | 1 |
| 13 | Electrode Performance Test on Single Ceramic Fuel Cell Using as Electrolyte Sr- and Mg-doped LaGaO3 显示文摘 | Huang Keqin Feng Man John B | 1997 | Journal of the American Ceramic Society1997，144，10： | 1 |
| 14 | Harmonization of health data at national level:A pilot studyin China显示文摘 | Danhong Liua Xia Wang Feng Pan Peng Yang Yongyong Xu Xuejun Tang Jianping Hu Keqin Rao | | 0，，06： | 1 |
| 15 | Inhomogeneous Quantum Codes (III):The Asymmetric Case显示文摘The stabilizer(additive)method and non-additive method for constructing asymmetric quantum codes have been established.In this paper,these methods are generalized to inhomogeneous quantum codes. | Weiyang WANG Keqin FENG | 2014 | Chinese Annals of Mathematics,Series B2014，35，2： | 1 |
| 16 | Constructing Symmetric Boolean Functions With Maximum Algebraic Immunity显示文摘 | QU Longjiang FENG Keqin LIU Feng | 2009 | IEEE Transactions on Information Theory2009，55，5： | 1 |
| 17 | In situ synthesis of TiC/Fe composites by reaction casting显示文摘 | Feng Keqin | 2005 | Materials and Design2005，，26： | 1 |
| 18 | Genus distribution of ladder type and cross type graphs显示文摘In this paper a method is given to calculate the explicit expressions of embedding genus distribution for ladder type graphs and cross type graphs. As an example, we refind the genus distri- bution of the graph Jn which is the first class of graphs studied for genus distribution where its genus depends on n. | WAN LiangXia FENG KeQin LIU YanPei WANG DianJun | 2009 | Science China Mathematics2009，52，8： | 1 |
| 19 | On the weight distribution of two classes of cyclic codes 显示文摘 | LUO Jinquan FENG Keqin | 2008 | IEEE Trans Inf Theory2008，54，5： | 1 |
| 20 | Electrode performance test on single ceramic fuel cell using as electrolyte Sr-and Mg-doped LaGaO3显示文摘 | HUANG Keqin FENG Man GOODENOUGR J B | 1997 | J Electrochem Soc1997，，144： | 1 |
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