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| 1 | 金属镍高温氧化机理及稀土元素效应研究显示文摘对纯镍及其表面离子注钇试样在1000℃空气中的恒温氧化和循环氧化行为进行了研究。用扫描电镜(SEM)和透射电镜(TEM)对氧化膜的表面形貌及结构进行了观测。此外,用声发射(AE)技术研究了氧化膜/基体界面上缺陷的分布情况,并用激光拉曼(Raman)谱对注钇引起的膜内应力变化进行了测量。结果表明:离子注钇降低了NiO氧化膜的生长速率,提高了镍的抗氧化性能;离子注钇减小了表面NiO的晶粒尺寸,降低了膜内压应力水平;离子注钇还减小了氧化膜/基体界面缺陷的平均尺寸和数目,因而极大地提高了镍表面NiO氧化膜的粘附性和保护性。 | 靳惠明 陈荣发 张剑峰 FELIX A Conrado | 2004 | 机械工程材料2004，28，5： | 8 |
| 2 | Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation显示文摘BACKGROUND Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCD1)protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis.In a phase IIb clinical trial in patients with nonalcoholic steatohepatitis(NASH),52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c,an indicator of glycemic control.AIM To assess lipid and glucose metabolism in mouse hepatocytes and in a NASH mouse model[induced with a 0.1%methionine and choline deficient diet(0.1MCD)]after treatment with Aramchol.METHODS Isolated primary mouse hepatocytes were incubated with 20μmol/L Aramchol or vehicle for 48 h.Subsequently,analyses were performed including Western blot,proteomics by mass spectrometry,and fluxomic analysis with 13C-uniformly labeled glucose.For the in vivo part of the study,male C57BL/6J mice were randomly fed a control or 0.1MCD for 4 wk and received 1 or 5 mg/kg/d Aramchol or vehicle by intragastric gavage for the last 2 wk.Liver metabolomics were assessed using ultra-high-performance liquid chromatography-time of flight-MS for the determination of glucose metabolism-related metabolites.RESULTS Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in hepatocytes.This translated into changes in the content of their downstream targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(S79),SCD1,CPT1A/B,HADHA,and HADHB],oxidative phosphorylation(NDUFA9,NDUFB11,NDUFS1,NDUFV1,ETFDH,and UQCRC2),tricarboxylic acid(TCA)cycle(MDH2,SUCLA2,and SUCLG2),and ribosome(P-p70S6K[T389]and P-S6[S235/S236]).Flux experiments with 13Cuniformely labeled glucose showed that TCA cycle cataplerosis was reduced by Aramchol in hepatocytes,as indicated by the increase in the number of rounds that malate remained in the TCA cycle.Finally,liver metabolomic analysis showed that glucose homeostasis was improved by Aramchol in 0.1MCD fed mice in a dose-dependent manner,showing normalization of glucose,G6P,F6P,UDP-glucose,and Rbl5P/Xyl5P.CONCLUSION Aramchol exerts its effect on glucose and lipid metabolism in NASH through activation of AMPK and inhibition of mTORC1,which in turn activate FAβ-oxidation and oxidative phosphorylation. | David Fernández-Ramos Fernando Lopitz-Otsoa Laura Delacruz-Villar Jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina Serrano-Macia Mikel Azkargorta Marta Iruarrizaga-Lejarreta Jesús Sot Darya Tsvirkun Sebastiaan Martijn van Liempd Felix M Goni Cristina Alonso María Luz Martínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu JoséM Mato | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 3 | Clinical implications of diabetes in chronic liver disease:Diagnosis,outcomes and management,current and future perspectives显示文摘Diabetes mellitus(DM)is common in liver cirrhosis(LC).The pathophysiological association is bidirectional.DM is a risk factor of LC and LC is a diabetogenic condition.In the recent years,research on different aspects of the association DM and LC has been intensified.Nevertheless,it has been insufficient and still exist many gaps.The aims of this review are:(1)To discuss the latest understandings of the association of DM and LC in order to identify the strategies of early diagnosis;(2)To evaluate the impact of DM on outcomes of LC patients;and(3)To select the most adequate management benefiting the two conditions.Literature searches were conducted using Pub Med,Ovid and Scopus engines for DM and LC,diagnosis,outcomes and management.The authors also provided insight from their own published experience.Based on the published studies,two types of DM associated with LC have emerged:Type 2 DM(T2 DM)and hepatogenous diabetes(HD).High-quality evidences have determined that T2 DM or HD significantly increase complications and death pre and post-liver transplantation.HD has been poorly studied and has not been recognized as a complication of LC.The management of DM in LC patients continues to be difficult and should be based on drug pharmacokinetics and the degree of liver failure.In conclusion,the clinical impact of DM in outcomes of LC patients has been the most studied item recently.Nevertheless many gaps still exist particularly in the management.These most important gaps were highlighted in order to propose future lines for research. | Diego García-Compeán Emanuela Orsi Ramesh Kumar Felix Gundling Tsutomu Nishida Jesús Zacarías Villarreal-Pérez Ángel N Del Cueto-Aguilera JoséA González-González Giuseppe Pugliese | 2022 | World Journal of Gastroenterology2022，28，8： | 4 |
| 4 | Sedated vs unsedated colonoscopy:A prospective study显示文摘AIM:To compare sedated to unsedated colonoscopy in terms of duration,pain and the patient’s willingness to repeat the procedure.METHODS:Consecutive patients who underwent colonoscopies over a 2-year period were invited to participate.All patients who were to undergo our endoscopy unit were offered sedation with standard intravenous sedatives and analgesics,or an unsedated colonoscopy was attempted.Demographic details were recorded.The patient anxiety level prior to the procedure,time to reach the cecum,total discharge time,patient and endoscopist pain assessments,satisfaction after the examination and the patient’s willingness to return for the same procedure in the future were recorded.RESULTS:Among the 403 observed patients,more males were observed in the unsedated group(66.2%vs 55.2%,P=0.04).Additionally,the unsedated group patients were less anxious prior to the procedure(5.1vs 6.0,P<0.01).The colonoscopy completion rates were comparable between the 2 groups(85.9%vs84.2%,P=0.66).The time to reach the cecum was also comparable(12.2 min vs 11.8 min);however,the total discharge times were shorter in the unsedated group(20.7 min vs 83.0 min,P<0.01).Moreover,the average patient pain score(3.4 vs 5.7,P<0.01)was lower in the sedated group,while the satisfaction score(8.8 vs 7.8,P<0.01)was significantly higher.There was no significant difference,however,between the groups in terms of willingness to repeat the procedure if another was required in the future(83.3%vs 77.3%,P=0.17).CONCLUSION:Unsedated colonoscopy is feasible in willing patients.The option saves the endoscopy units up to one hour per patient and does not affect the patient willingness to return to the same physician again for additional colonoscopies if a repeated procedure is needed. | Abdulrahman M Aljebreen Majid A Almadi Felix W Leung | 2014 | World Journal of Gastroenterology2014，20，17： | 3 |
| 5 | Long-term follow-up of quality of life in high-risk patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis显示文摘BackgroundTranscatheter 大动脉的阀门培植(TAVI ) 与严重征兆的大动脉的狭窄为病人成为了标准治疗(作为) 为外科的大动脉的阀门代替在很高的风险考虑了。这亚学习的目的是评估长期的(> 4 年) 在 octogenarians 的生活(QoL ) 的健康相关的质量经历了 TAVI.MethodsA 单个中心在在 TAVI 以后经历了框架分析评价 4 年的二十个病人的观察登记。健康相关的 QoL 被评估,用短 Form-36 ( SF-36 ),吗 EuroQoL-5D ( EQ-5D )和 questionnaires.ResultsThe 平均数 SF-36 subscale 在后续获得的视觉类似物分数(EQ管)是物理的工作 40.8 ????????????????????????????搠?潮潶???吗?湡楧灯慬瑳?????????愠杮潩牧灡票?€ 敦潭潲潰汰瑩慥???????????????愠桴牥'啼蠹溃浚? | Marjo JAG De Ronde-Tillmans Tom AJ de Jager Jeannette A Goudzwaard Nahid El Faquir Nicolas M van Mieghem Felix Zijlstra Elisabeth MWJ. Utens Francesco US Mattace-Raso MaRie J Lenzen Peter PT de Jaegere | 2018 | Journal of Geriatric Cardiology2018，15，4： | 3 |
| 6 | 水斗式水轮机流动数值计算与试验研究——射流自由表面流动显示文摘通过数值计算与试验研究,对水斗式水轮机喷嘴解流自由表面流动进行了研究。一种特殊光学仪器的开发使得可以首次采用激光多普勒风速计(LDA)测量射流内速度,对射流照片的分析获得了射流形状和射流表面的宝贵资料。上述数据可用于验证两种不同流动模拟程序,验证结果表明,必须精确计算出射流从喷嘴分离的位置,才可以准确预测出射流速度分布,这说明,了解数值计算软件的限制性后,它将成为水斗式水轮机有效设计工具。 | Felix A 戴然 等 | 2001 | 国外大电机2001，，3： | 3 |
| 7 | Effects of obstructive sleep apnea and its treatment over the erectile function: a systematic review显示文摘可勃起的机能障碍(编辑) 与大量病原学被认为一个条件。妨碍的睡觉呼吸暂停(OSA ) 症候群是为我们打算在在 OSA 和性缺陷之间的关系上总结当前的证据的编辑的更小的学习风险因素之一,集中于以提供给 OSA 病人的不同治疗的可勃起的功能的结果。系统的评论被进行,选择与 OSA 和编辑的生理学有关的文章,并且到在可勃起、性的功能的 OSA 症候群和他们的报导结果的治疗。在 OSA 组的编辑的更高的流行被出版了。然而,可勃起的功能上的这效果是否发生在 OSA 严厉的全部范围,仍然保持不清楚。几个假设被建议解释这个协会的生理学。为有编辑的 OSA 病人的治疗在大多数研究在性参数完成了有意义的改进的连续积极航线压力。需求上的 Phosphodiesterase 类型 5 禁止者(iPDE5 ) 作为为在病人的这亚群的编辑的治疗有用,与高满足率。为证实的 OSA 的外科的治疗用 mandible 的前进设备在治疗的性满足上在可勃起的功能,和效果上受益仍然是未定义的。 | Felix Campos-Juanatey Marcos Fernandez-Barriales Monica Gonzalez Jose A Portillo-Martin | 2017 | Asian Journal of Andrology2017，19，3： | 2 |
| 8 | Removal of cardiodepressant antibodies in dilated cardiomyopathy by immunoadsorption显示文摘 | Felix SB Staudt A Landsberger M | 2002 | J Am Coll Cardiol2002，39，4： | 1 |
| 9 | The antagonism of glueoeortieoid inhibition of wound healing in rats by growth hormone-releasing factor显示文摘 | Kelley S F Felix A M Ehrlieh H P | 1990 | Proe Soe Exp Biol Med1990，194，4： | 1 |
| 10 | TLR11 Activation of dendritic cells by a protozoan profilin-like protein显示文摘 | Felix Y Dekai Z John F A | 2005 | Science2005，308，5728： | 1 |
| 11 | A method for the determination of volatile N-nitrosamines in food by HS-SPME-GC-TEA 显示文摘 | Raquel A Felix G R Susanne R | 2005 | Food Chemistry2005，91，1： | 1 |
| 12 | Variant angina associated with bitter orange in a dietary supplement显示文摘 | Gange C A Madias C Felix Gretzik E M | 2006 | Mayo Clinic Proc2006，81，： | 1 |
| 13 | Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial显示文摘 | Benjamin M Scirica Marc P Bonaca Eugene Braunwald Gaetano M De Ferrari Daniel Isaza Basil S Lewis Felix Mehrhof Piera A Merlini Sabina A Murphy Marc S Sabatine Michal Tendera Frans Van de Werf Robert Wilcox David A Morrow | 2012 | The Lancet . 2012 (9850)2012，，9850： | 1 |
| 14 | Latent heat thermal energy storage using cylindrical capsule: Numerical and experimental investigations 显示文摘 | A Felix Regin S C Solanki J S Saini | 2006 | Renewable Energy2006，31，13： | 1 |
| 15 | Parallcl ization of the Scatter Search for the p median Problem 显示文摘 | FELIX G L BELEN M B JOSE A M P | 2003 | Parallel Computing2003，29，5： | 1 |
| 16 | Environmental impact and management of phosphogypsum 显示文摘 | Hanan T Mohamed C Felix A L | 2009 | Journal of Environmental Man- agement2009，90，8： | 1 |
| 17 | Etiology of esophageal atresia and tracheoesophageal fistula: 'mind the gap'显示文摘 | de Jong EM Felix JF de Klein A | 2010 | Curr Gastroenterol Rep2010，12，3： | 1 |
| 18 | Uphill permeation of Cr(Ⅵ) using Hostarex A327 as ionophore by membrane-solvent extraction processing显示文摘 | Francisco J A Manuel A Felix L | 2008 | Chemosphere2008，72，： | 1 |
| 19 | A bound for the nilpotency of a group of self homotopy equivalences 显示文摘 | FELIX Y MURILLO A | 1997 | Bull London Math Soc1997，29，： | 1 |
| 20 | Blood neuron-specific enolase in newborns with perinatal asphyxia 显示文摘 | Verdu Perez A Falero MP Arroyos A Estevez F Felix V Lopez Y | 2001 | Rev Neurol2001，32，8： | 1 |
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