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| 1 | Potential mechanisms of hepatitis B virus induced liver injury显示文摘Chronic active hepatitis(CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular carcinoma.The histological end points of CAH are chronic inflammation,fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal livers.The potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis,inflammation and cytokine production and liver scaring(fibrosis).The severity of liver damage is regulated by Hepatitis B virus genotypes and viral components.The viral and cellular factors that contribute to liver injury are discussed in this article.Liver injury caused by the viral infection affects many cellular processes such as cell signaling,apoptosis,transcription,DNA repair which in turn induce radical effects on cell survival,growth,transformation and maintenance.The consequence of such perturbations is resulted in the alteration of bile secretion,gluconeogenesis,glycolysis,detoxification and metabolism of carbohydrates,proteins,fat and balance of nutrients.The identification and elucidation of the molecular pathways perturbed by the viral proteins are important in order to design effective strategy to minimize and/or restore the hepatocytes injury. | Mohd Suhail Hany Abdel-Hafiz Ashraf Ali Kaneez Fatima Ghazi A Damanhouri Esam Azhar Adeel GA Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，35： | 12 |
| 2 | 中医药在巴西的发展现状与分析显示文摘巴西医疗保险以统一医疗体系(Unified Health System,SUS)的免费医疗为主、私人保险为补充,已实现全民享有基本医疗服务。导致该国居民死亡的主要疾病是缺血性心脏病、脑卒中、下呼吸道感染,近年来AD、慢性肾脏病及糖尿病的发病率显著增高。以针灸为代表的中医疗法在19世纪初传入巴西,目前针灸治疗已得到较广泛的认可和应用,被纳入SUS,并在多所高校开设相关课程,但中医药整体特色有待加强,从业人员对中药的理解、运用不足,以及中医药教育缺乏规范等问题限制了中医药在巴西的发展。建议通过发挥中医药治未病的特色,加大中药研发力度并扩大市场,规范中医教育等措施,促进两国在中医药领域的广泛合作,推动中医药在巴西的发展与传播。 | 李皓月 党迎迎 Thaís Salles Araujo Fatima Terezinha Pelachini Farias Jaime Amador Soares Graciela Mendonça da Silva de Medeiros 于涛 魏竞竞 赵静 许家杰 曹洪欣 | 2021 | 国际中医中药杂志2021，43，5： | 5 |
| 3 | Concurrent use of aromatase inhibitors and hypofractionated radiation therapy显示文摘AIM: To retrospectively assess the acute and long-term toxicity using aromatase inhibitors (AI) therapy concurrently with hypofractionated radiotherapy (HFRT) in breast cancer patients. METHODS: From November 1999 to October 2007, 66 patients were treated with breast HFRT and concurrent AI. In 63 patients (95.5%), HFRT delivered a total dose of 32.5 Gy to the whole breast within 5 wk (five fractions, one fraction per week). Other fractionations were chosen in three patients for the patients' personal convenience. A subsequent boost to the tumor bed was delivered in 35 patients (53.0%). Acute toxicities were scored according to the Common Toxicity Criteria for Adverse Events v3. Late toxicity was defined as any toxicity occurring more than 6 mo after completion of HFRT and was scored according to the Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic scale. RESULTS: At the end of the HFRT course, 19 patients (28.8%) had no irradiation-related toxicity. Acute grade 1-2 epithelitis was observed in 46 patients (69.7%). One grade 3 toxicity (1.5%) was observed. With a median follow-up of 34 mo (range: 12-94 mo), 31 patients (47%) had no toxicity, and 35 patients (53%) presented with grade 1-2 fibrosis. No grade 3 or greater delayed toxicity was observed. CONCLUSION: We found that AI was well tolerated when given concurrently with HFRT. All toxicities were mild to moderate, and no treatment disruption was necessary. Further prospective assessment is warranted. | Cyrus Chargari Pablo Castro-Pena Ivan Toledano Marc A Bollet Alexia Savignoni Paul Cottu Fatima Laki Franois Campana Patricia De Cremoux Alain Fourquet Youlia M Kirova | 2012 | World Journal of Radiology2012，4，7： | 2 |
| 4 | Recovery of heat-injured Listeria innocua显示文摘 | FATIMA A MILLER T R S PAULA T | 2006 | International Journal of Food Microbiology2006，112，： | 1 |
| 5 | Ocular surface changes in limbal stem cell deficiency caused by chemical injury: a histologic study of excised pannus from recipients of cultured corneal epithelium显示文摘 | Fatima A Iftekhar G Sangwan VS | 2008 | Eye2008，22，9： | 1 |
| 6 | Association of XRCC1 gene polymorphisms with breast cancer suscepti- bility in saudi patients 显示文摘 | Fatima M Mohammed A Manal S | 2013 | Asian Pacific J Cancer Prev2013，14，6： | 1 |
| 7 | Antimicrobial potential of Glycyrrhiza glabra roots 显示文摘 | Gupta V K Fatima A Faridi U | 2008 | J Ethnopharmacol2008，，116： | 1 |
| 8 | RP - HPLC method for the quan- titation of glabridin inYashti - madhu ( Glycyrrhiza glabra) 显示文摘 | Shanker K Fatima A Negi A S | 2007 | Chro- matographia2007，65，1112： | 1 |
| 9 | Antifunga! activity of Glycyrrhiza glabra extracts and its active con- stituent glabridin 显示文摘 | FATIMA A GUPTA V K LUQMAN S | 2009 | Phytotherapy Research2009，23，8： | 1 |
| 10 | Sustainable Development in Pakistan in the Context of Energy Consumption Demand and Environmental Degradation显示文摘 | ALAM S FATIMA A BUTF M S | 2007 | Journal of Asian Economics2007，18，5： | 1 |
| 11 | Pollen parent enhances fruit size and quality in intervarietal crosses in guava (Psidium guajava)显示文摘 | Usman M Samad W A Fatima B | | 0，，1： | 1 |
| 12 | Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes 显示文摘 | Maheshwari A Gurunath S Fatima F | 2012 | Hum Reprod Update2012，18，4： | 1 |
| 13 | Cytotoxicity of goniothalamin enantiomers in renal cancer cells: involvement of nitric oxide, apoptosis and autophagy 显示文摘 | De Fatima A Zambuzz W F Modolo L V | 2008 | Chem Biol Interact2008，176，23： | 1 |
| 14 | Sustainable development in Pakistan in the COntext of energy Consumption demand and environmental degradation显示文摘 | Alam S Fatima A Butt M S | 2007 | Journal of Asian Economies2007，18，5： | 1 |
| 15 | Antimicrobial susceptibili- ty pattern of clinical isolates of Pseudomonas aeruginosa isolat- ed from patients of lower respiratory tract infections显示文摘 | Fatima A Naqvi S B Khaliq S A | 2012 | Spring- erplus2012，1，1： | 1 |
| 16 | Asymmetric total synthesis and antiproliferative activity of goniothalamin oxide isomers 显示文摘 | Marquissolo C De Fatima A Kohn L K | 2009 | BioorgChem2009，37，2： | 1 |
| 17 | Effect of missing walls on the compression behaviotrr of honeycombs显示文摘 | ALBUQUERQUE J M FATIMA M FORTES M A | 1999 | Scripta Materialia1999，41，2： | 1 |
| 18 | Bronchial artery embolization in the treatment of massive hemoptysis 显示文摘 | Bin Sarwar Zubairi A Tanveer-ul-Haq Fatima K | 2007 | Saudi Med J2007，28，7： | 1 |
| 19 | Shelf life of shrimp (Penaeus merguiensis) stored in ice and partially frozen显示文摘 | Fatima R Khan M A Qadri R B | 1988 | J Sci Food Agric1988，42，： | 1 |
| 20 | Antifungal activity of Glycyrrhiza glabra extracts and its active con- stituent glabridin 显示文摘 | FATIMA A GUPTA V K LUQMAN S | 2009 | Phytother Res2009，23，8： | 1 |
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