|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Moringa oleif-era:bioactive compounds and nutritional potential显示文摘 | FERREIRA P M P FARIAS D F OLIVEIRA J T A | 2008 | Brazilian Journal ofNutrition2008，21，4： | 1 |
| 3 | Excessive u-rokinase-type plasminogen activator activity in the euglobu-lin fraction of patients with Alzheimer-type dementia显示文摘 | Alonso D F Farias E F Famulari A L | 1996 | JNeurol Sci1996，139，1： | 1 |
| 4 | Xylanases from Cryptococcus flavus isolate I-11:Enzymatic profile,isolation and heterologous expression of CfXYN1 in Saccharomyces cerevisiae显示文摘 | PARACHIN N S SIQUEIRA S FARIA F P D | 2009 | Journal of Molecular Catalysis B:Enzymatic2009，59，123： | 1 |
| 5 | On the Efficiency- Fairness Trade-off 显示文摘 | Bertsimas D Farias V F Trichakis N | 2012 | Management Science2012，58，12： | 1 |
| 6 | Role of dehydration catalyst acid properties on one-step DME synthesis over physical mixtures显示文摘 | Ramos F S De Farias A M D Borges L E P | 2005 | Catal Today2005，101，1： | 1 |
| 7 | Desempenho, qualidade dos ovos e balanqo de nitrogEnio de poedeiras comerciais alimentadas corn raq6es contendo diferentes niveis de protefna bruta e lisina 显示文摘 | RIZZO SILVA M F EMYGDIO DE FARIA D WICK RIZZOLI P | 2010 | Revista Brasileira deZootecnia2010，39，6： | 1 |
| 8 | Phase-dependent effects in bichromatic high -order harmonic generation显示文摘 | Milosevic D B Paulus G G | 2000 | Phys Rev A2000，61，06： | 1 |
| 9 | Characterization of Brazilian lager and brown ale beers based on color,phenolic compounds and antioxidant activity using chemometrics显示文摘 | GRANATO D BRANCO G F FARIA JDAF | 2011 | Journal of the Science of Food and Agriculture2011，91，3： | 1 |
| 10 | Fairness, Efficiency, and Flexibility in Organ Allocation for Kidney Transplantation显示文摘 | Bertsimas D Farias V F Trichakis N | 2013 | Operations research2013，61，1： | 1 |
| 11 | Larvicidal activity of the water extract of Moringa oleifera seeds against Aedes aegypti and its toxicity upon laboratory ani- mals 显示文摘 | Ferreira P M P Carvalho A F Farias D F | 2009 | Anais da Academia Brasileira de Ci~ncias2009，81，2： | 1 |
| 12 | Cooperation in innovation activities: The importance of partners显示文摘 | Faria D Lima F Santos | 2010 | Research Policy2010，39，： | 1 |
| 13 | Production and structural characterization of Surfactin (C14/ Leu7) produced by Bacillus subtilis isolate LSFM-05 grown on raw glycerol from the biodiesel industry显示文摘 | de Faria A F Teodoro-Martinez D S Barbosa G N O | 2011 | Process Biochem- istry2011，46，10： | 1 |
| 14 | Unveilingthe role of oxidation debris on the surface chemistry ofgraphene through the anchoring of Ag nanoparticles显示文摘 | FARIA A F MARTINEZ D S T MORAES A C M | 2012 | Chemistryof Materials2012，24，21： | 1 |
| 15 | Desempenho,qualidade dos ovos e balanco de nitrog(e)nio de poedeiras comerciais alimentadas com rac(o)es contendo diferentes níveis de proteína bruta e lisina显示文摘 | RIZZO SILVA M F EMYGDIO DE FARIA D WICK RIZZOLI P | 2010 | Revista Brasileira de Zootecnia2010，39，6： | 1 |
| 16 | Comparisons between the Nottingham Health Profile and the Short Form-36 for assessing the quality of life of communitydwelling elderly显示文摘 | Faria C D Teixeira-Salmela L F Nascimento V B | 2011 | Rev Bras Fisioter2011，15，5： | 1 |
| 17 | On the efficiency-fairness trade-off显示文摘 | BERTSIMAS D FARIAS V F TRICHAKIS N | 2012 | Management Science2012，58，12： | 1 |
| 18 | Metabolic programming of ovarian angiogenesis and folliculogenesis by maternal malnutrition during lacta- tion显示文摘 | FERREIRA R V GOMBAR F M FARIA T D | 2010 | Fertility and Sterility2010，93，8： | 1 |
| 19 | Desempen- ho,qualidade dos ovose balango de nitrognio de poedeiras com- erciais alimentadas com raffles contendo diferentes niveis de proteina bruta e lisina显示文摘 | Silva M F R De Faria D E Rizzoli P W | 2010 | Revista Brasileira de Zootecnia2010，39，6： | 1 |
| 20 | Modification of silica gel by attachment of 2 - mercapto- benzimidazole for use in removing Hg ( Ⅱ ) from aqueous media: A thermodynamic approach 显示文摘 | Alcantara E F C Faria E A Rodrigues D V | 2007 | Colloid and Interface Science2007，311，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员