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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Energy Structure,Marginal Efficiency and Substitution Rate:An Empirical Study of China显示文摘 | HanZY FanY JiaoJL YanJS Wei Y M | 2007 | Energy2007，32，6： | 1 |
| 3 | Dynamic modeling and optimal control of DFIG wind energy systems using DFT and NSGA-II显示文摘 | ZAMANIFAR M FANI B GOLSHAN M E H | 2014 | Electric Power Systems Research2014，108，： | 1 |
| 4 | Measurement of the dynamic displacements and of the modal frequencies of a shorkspan pedestrian bridge using GPS and an accelerometer显示文摘 | Fanis M Stathis S | 2011 | Engineering Structures2011，33，： | 1 |
| 5 | Study of the Labeling of Two Novel RGD-Peptidic Derivatives With the Precursor ^+ and Evaluation for Early Angiogenesis Detection in Cancer显示文摘 | Psimadas D Fani M Zikos C | 2004 | Appl Radiat Isot2004，31，： | 1 |
| 6 | Isolation of a lectin and a galactoxyloglucan from Mucuna sloanei seeds显示文摘 | DANIELE M A TEIXEIRA-S(A) FANY REICHER BRAGA RENATA C | 2009 | Phytochemistry2009，70，1718： | 1 |
| 7 | Radiopharmaceutical development of radiolabelled peptides 显示文摘 | Fani M Maeeke HR | 2012 | Eur J Nuel Med Imaging2012，39，1： | 1 |
| 8 | Effect of Pressure on the Solid-Liquid Equilibria of Synthetic Paraffin Mixtures Using Predictive Methods 显示文摘 | Nasrifar K Fani Kheshty M | 2011 | Fluid Phase Equilibria2011，310，11： | 1 |
| 9 | Inhibitory activity of green tea(Camellia sinensis)extract on some clinically isolated cariogenic and periodontopathic bacteria显示文摘 | Araghizadeh A Kohanteb J Fani M M | 2013 | Medical Principles and Practice2013，22，4： | 1 |
| 10 | Phylogeny of the genus AzospiriUum based on 16S rDNA sequence显示文摘 | Fani R Bandi C Bazziealupo M | 1995 | FEMS Microbiology Letters1995，129，23： | 1 |
| 11 | Optimization of β-carotene production from synthetic medium by Blakcslea trispora显示文摘 | FANI M TRIANTAFYLLOS R | 2002 | Applied Biochemistry and Bioteehnology2002，101，： | 1 |
| 12 | Epigenetic regulation of osteogenic and chondrogenic differentiation of mesenchymal stem ceils incuhure显示文摘 | Eslaminejad M B Fani N Shahhoseini M | 2013 | Cell J2013，15，1： | 1 |
| 13 | Evolution of lactic acid bac- teria in the order Lactobacillales as depicted by analysis of glycolysis and pentose phosphate pathways显示文摘 | SALVETTI E FONDI M FANI R | 2013 | Syst Appl Microbiol2013，36，5： | 1 |
| 14 | Analysis on additive effects and additive-by-additive epistatlc effects of QTLs for yield traits in a recombinant inbred line population of rice 显示文摘 | Zhuang J Y FanY Y Rao Z M | 2002 | Theor Appl Genet2002，105，： | 1 |
| 15 | Inhibitory activity of garlic(Allium sativum)extract on multidrug-resistant Streptococcus mutans显示文摘 | Fani MM Kohanteb J Dayaghi M | 2007 | J Indian Soc Pedod Prev Dent2007，25，4： | 1 |
| 16 | Development of new folate-based PET radiotracers:preclinical evaluation of(68)Ga-DOTA-folate conjugates显示文摘 | Fani M Wang X Nicolas G | 2010 | Eur J Nucl Med Mol Imaging2010，19，： | 1 |
| 17 | A computer-vision system and methodology for the analysis of fish behavior显示文摘 | Vassilis M Papadakis Ioannis E Papadakis Fani Lamprianidou | 2012 | Aquacultural Engineering January2012，46，1： | 1 |
| 18 | Phylogeny of the genus Azospirilllum based on 16S rDNA sequence 显示文摘 | FANI R BANDI C BAZZICALUPO M | 1995 | FEMS Microbiol Letters1995，129，： | 1 |
| 19 | A horizontal gene transfer at the origin of phenylpropanoid metabolism : a key adaptation of plants to land 显示文摘 | Emiliani G Fondi M Fani R | 2009 | Biology Direct2009，4，1： | 1 |
| 20 | Study of the Labeling of Two Novel RGD-peptidic Derivatives With the Precursor^+ and Evaluation for Early Angiogenesis Detection in Cancer显示文摘 | PSIMADAS D FANI M ZIKOS C | 2004 | Applied Radiation and Isotopes2004，31，： | 1 |
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