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| 1 | Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis显示文摘AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)risk.METHODS:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,respectively.Data were analysed for single site and haplotype association with IBD risk and phenotype.Meta-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with IBD.All published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified studies.Imputed genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel method.The New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,respectively.RESULTS:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni correction.Meta-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall IBD.Similarly,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients,789 controls)found no association of this promoter polymorphism with UC. | James D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay Richard B Gearry Rebecca L Roberts | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Initial Combination Therapy Reduces the Risk of Cardiovascular Events in Hypertensive Patients: A Matched Cohort Study显示文摘 | Alan H. Gradman Hélène Parisé Patrick Lefebvre Heather Falvey Marie-Hélène Lafeuille Mei Sheng Duh | 2013 | Hypertension2013，，2： | 2 |
| 3 | North -- South Trade, Know ledge Spillovers and Growth 显示文摘 | Falvey Foster and Greenaway | 2002 | Journal of Economic Integration2002，，17： | 1 |
| 4 | Photochemical generation of nitrenium ions from protonated 1,1- diarylhydrazines 显示文摘 | Winter A H Thomas S L Falvey D E | 2004 | Org Lett2004，6，25： | 1 |
| 5 | Diabetes, glucose control, and 9- year cognitive decline among older adults without dementia 显示文摘 | Yaffe K Falvey C Hamilton N er al | 2012 | Arch Neurol2012，69，9： | 1 |
| 6 | Imports, exports, knowledge spillovers and growth 显示文摘 | Rod Falvey Neil Foster David Greenaway | 2004 | Economics Letters2004，85，： | 1 |
| 7 | Northsouth trade,knowledge spillovers and growth 显示文摘 | Falvey Rod Nell Foster David Greenaway | 2002 | Journal of Economic Integration2002，17，： | 1 |
| 8 | Imports, exports,knowledge spillovers and growth显示文摘 | Falvey Rod Nell Foster David Greenaway | 2004 | Economics Letters2004，85，： | 1 |
| 9 | Intellectual property rights and economic growth 显示文摘 | Falvey R Foster N Greenway D | 2006 | Review of Development Economics2006，10，4： | 1 |
| 10 | The development of continental margins in plate tectonic theory 显示文摘 | Falvey D A | 1974 | Journal of Association of Petroleum and Explosives Administration1974，14，： | 1 |
| 11 | Hydraulic and Design of Fusegates显示文摘 | FALVEY H TREILLE P | 1995 | Journal of Hydraulic Engineering1995，，： | 1 |
| 12 | A Formalisation and Test of the Factor Productivity Explanation of International Differences in Service Prices 显示文摘 | FALVEY RODNEY E GEMMELL | 1996 | International Economic Review1996，37，1： | 1 |
| 13 | Patient-based not prob- lern-based learning:an oslerian approach to clinical skills,looking back to move forward显示文摘 | Franklyn-Miller AD Falvey EC | 2009 | J Postgrad Med2009，55，3： | 1 |
| 14 | A hypothesis for the formation of marginal seas in the western Pacific显示文摘 | Packham G H Falvey D A | 1971 | Tectonophysics1971，11，2： | 1 |
| 15 | Commercial Policy and IIT显示文摘 | Falvey R E | 1981 | Journal of International Economics1981，11，： | 1 |
| 16 | The development of continental margins inplate tectonic theory 显示文摘 | Falvey D A | 1974 | Australian Petroleum Explora-tion Association Journal1974，14，1： | 1 |
| 17 | Bilayer vesicles of amphiphilic cyclodextrins:Host membranes that recognize guest molecules显示文摘 | Falvey P Lim C W Darcy R | 2005 | Chemistry-A European Journal2005，11，4： | 1 |
| 18 | Patient- based not problem-based learning: an Oslerian approach to clinical skills, looking back to move forward显示文摘 | Franklyn-Miller AD Falvey EC MeCrory PR | 2009 | J Post- grad Med2009，55，3： | 1 |
| 19 | Predicting Cavitation in Tunnel Spillway显示文摘 | Falvey H.T | | 0，，08： | 1 |
| 20 | Intellectual property rights and economic growth显示文摘 | FALVEY R FOSTER N GREENAWAY D | 2006 | Review of Development Economics2006，10，4： | 1 |
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