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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Decrease in the number and apoptosis of alveolar bone osteoclasts in estrogen-treated rats显示文摘 | Faloni APS Sasso-Cerri E Katchburian E Cerri PS | 2007 | J Periodont Res2007，42，： | 1 |
| 3 | Decrease in the number and apoptosis of alveolar bone osteoclasts in estrogen -treated rats显示文摘 | Faloni AP Sasso-Cerri E Katchburian E | 2007 | J Periodontal Res2007，42，3： | 1 |
| 4 | Decrease in the number and apoptosis of alveolar bone osteoclasts in estrogen-treated rats 显示文摘 | Faloni APS Sasso Ceri E Katchburian E Cerri PS | 2007 | J Periodont Res2007，42，： | 1 |
| 5 | Decrease in the number and apoptosis of alveolar bone osteoclasts in estrogen-treated rats显示文摘 | Faloni AP Sasso-Cerri E Katchbttrian E | 2007 | J Periodontal Res2007，42，3： | 1 |
| 6 | Antiulcerogenic activity of extract, fractions, and some compounds obtained from Polygala cyparissias St. Hillaire & Moquin (Polygalaceae)显示文摘 | Luiz Carlos Klein Renan Becker Gandolfi José Roberto Santin Marivane Lemos Valdir Cechinel Filho Sérgio Faloni Andrade | 2010 | Naunyn - Schmiedeberg’s Archives of Pharmacology2010，，2： | 1 |
| 7 | First in vivo evaluation of the mutagenic effect of Brazilian green propolis by comet assay and micronucleus test显示文摘 | Alzira Danielly Pereira Sergio Faloni de Andrade Mário Sergio de Oliveira Swerts Edson Luis Maistro | 2008 | Food and Chemical Toxicology2008，，7： | 1 |
| 8 | Accurate approach in the treatment of oral bisphosphonate-re|ated jaw osteonecr- osis 显示文摘 | de Souza Faloni A P Queiroz T P Comelli Lia R C | 2011 | J Craniofac Surg2011，22，6： | 1 |
| 9 | Comberltance of the HR2 haplotype in the factor Ⅴ gene confers an increased risk of venous thrombosis to carriers of factor Ⅴ R506Q (factor Ⅴ leiden)显示文摘 | Fronchi F Bucclarelll P | 1999 | Blood1999，94，： | 1 |
| 10 | Population-level analysis of gut microbiome variation显示文摘 | Falony Q Joossens M Vieira-Silva S | 2016 | Science2016，352，6285： | 1 |
| 11 | Probiotics in fermented sausages显示文摘 | de VUYST L FALONY G LEROY F | 2008 | Meat Science2008，80，1： | 1 |
| 12 | Antiulcerogenic activity of extract, fractions, and some compounds obtained from Polygala cyparissias St. Hillaire & Moquin (Polygalaceae)显示文摘 | Luiz Carlos Klein Renan Becker Gandolfi José Roberto Santin Marivane Lemos Valdir Cechinel Filho Sérgio Faloni Andrade | 2010 | Naunyn - Schmiedeberg’s Archives of Pharmacology2010，，2： | 1 |
| 13 | Microbiology meets big data: the case of gut Microbiota-Derived trimethylamine 显示文摘 | Falony G Vieira-Silva S Raes J | 2015 | Annu Rev Microbiol2015，69，： | 1 |
| 14 | Probiotics in fermented sausages显示文摘 | De VUYST L FALONY G LEROY F | 2008 | Meat Science2008，80，1： | 1 |
| 15 | Coculture fermentations of Bifidobacterium species and Bacteroides thetaiotaomicron reveal a mechanistic insight into the prebiotic effect of inulin-type fructans显示文摘 | FALONY G CALMEYN T LEROY F | | 0，，： | 1 |
| 16 | In vitro kinetic analysis of fermentation of prebiotic inulin-type fructans by Bifidobacterium species reveals four different phenotypes显示文摘 | FALONY G LAZIDOU K VERSCHAEREN A | | 0，，： | 1 |
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