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| 1 | Recent advances in the molecular genetics of type 2 diabetes mellitus显示文摘Type 2 diabetes mellitus(T2DM) is a complex disease in which both genetic and environmental factors interact in determining impaired β-cell insulin secretion and peripheral insulin resistance. Insulin resistance in muscle, liver and fat is a prominent feature of most patients with T2DM and obesity, resulting in a reduced response of these tissues to insulin. Considerable evidence has been accumulated to indicate that heredity is a major determinant of insulin resistance and T2DM. It is believed that, among individuals destined to develop T2DM, hyperinsulinemia is the mechanism by which the pancreatic β-cell initially compensates for deteriorating peripheral insulin sensitivity, thus ensuring normal glucose tolerance. Most of these people will develop T2DM when β-cells fail to compensate. Despite the progress achieved in this field in recent years, the genetic causes of insulin resistance and T2DM remain elusive.Candidate gene association, linkage and genome-wide association studies have highlighted the role of genetic factors in the development of T2DM. Using these strategies, a large number of variants have been identified in many of these genes, most of which may influence both hepatic and peripheral insulin resistance, adipogenesis and β-cell mass and function. Recently, a new gene has been identified by our research group, the HMGA1 gene, whose loss of function can greatly raise the risk of developing T2DM in humans and mice. Functional genetic variants of the HMGA1 gene have been associated with insulin resistance syndromes among white Europeans, Chinese individuals and Americans of Hispanic ancestry. These findings may represent new ways to improve or even prevent T2DM. | Antonio Brunetti Eusebio Chiefari Daniela Foti | 2014 | World Journal of Diabetes2014，5，2： | 20 |
| 2 | Drag reduction via turbulent boundary layer flow control显示文摘Turbulent boundary layer control(TBLC) for skin-friction drag reduction is a relatively new technology made possible through the advances in computational-simulation capabilities,which have improved the understanding of the flow structures of turbulence.Advances in micro-electronic technology have enabled the fabrication of active device systems able to manipulating these structures.The combination of simulation,understanding and micro-actuation technologies offers new opportunities to significantly decrease drag,and by doing so,to increase fuel efficiency of future aircraft.The literature review that follows shows that the application of active control turbulent skin-friction drag reduction is considered of prime importance by industry,even though it is still at a low technology readiness level(TRL).This review presents the state of the art of different technologies oriented to the active and passive control for turbulent skin-friction drag reduction and contributes to the improvement of these technologies. | ABBAS Adel BUGEDA Gabriel FERRER Esteban FU Song PERIAUX Jacques PONS-PRATS Jordi VALERO Eusebio ZHENG Yao | 2017 | Science China(Technological Sciences)2017，60，9： | 4 |
| 3 | Reconstructing pre-erosion topography using spatial interpolation techniques: A validation-based approach显示文摘理解先于腐蚀地形的发展的地志的上下文具有在似地球形状的研究的主要关联,作为地形学是水和集体运动相关的侵蚀上的一个重要因素,并且原来的表面的知识是为确定的一个条件侵蚀的材料的体积。尽管任何重建暗示假设产生表面反映原来的地形学,过去的工作被线性插值方法统治了,不能在输入的变化的范围外面没有数据或值在区域产生弄弯的表面。尽管有这些限制,确认的不可能导致了表面 representativity 的假设从来没被质问。 | Rafaello BERGONSE Eusebio REIS | 2015 | Journal of Geographical Sciences2015，25，2： | 2 |
| 4 | , Resonance in subthalamo-co- rtical circuits in Parkinson's disease显示文摘 | Eusebio A Pogosyan A Wang S | 2009 | Brain2009，132，8： | 1 |
| 5 | Waterborne Acrylic Varnishes Durability on Wood Surfaces for Exterior Exposure显示文摘 | CUSTODIO J E P EUSEBIO M | 2006 | Progress in Organic Coatings2006，56，： | 1 |
| 6 | Comparison of changes in the percentages of CD8+CD28-TCR c~ 13 ~ T cell subpopulations in allergic asthma subjects vscontrols before and after anti-CD3/ anti-CD28/IL-2 stimulation in vitro 显示文摘 | Eusebio M Kraszula L Kupczyk M | 2013 | J Biol Regul Homeost Agents2013，27，4： | 1 |
| 7 | Turgor maintenance, osmotic adjustment and soluble sugar and praline accumulation in 49 pea cultivars in response to water stress显示文摘 | Francisco J Manzanares M Eusebio F | 1998 | Field Crops Res1998，59，3： | 1 |
| 8 | Novel cathode for field-emission application显示文摘 | Eusebio G McWilliams R D Voss D E | 1995 | Rev Sci Intrum1995，66，3： | 1 |
| 9 | Resonance in subthalamo-cortical circuits in Parkinson ' s disease显示文摘 | Eusebio A Pogosyan A Wang S | 2009 | Brain2009，132，8： | 1 |
| 10 | Antiparkinsonian drug-induced sleepiness: a double-blind placebo-controlled study of L-dopa, bromocriptine and pramipexole in healthy subjects 显示文摘 | Micallef J Rey M Eusebio A | 2008 | Br J Clin Phannaeol2008，67，： | 1 |
| 11 | Expression of matrix metalloproteinase-11 is increased under conditions of insulin resistance显示文摘AIM To investigate matrix metalloproteinase-11(MMP-11) expression in adipose tissue dysfunction, using in vitro and in vivo models of insulin resistance.METHODS Culture of mouse 3T3-L1 preadipocytes were induced to differentiation into mature 3T3-L1 adipocytes. Cellular insulin resistance was induced by treating differentiated cultured adipocytes with hypoxia and/or tumor necrosis factor(TNF)-α, and transcriptional changes were analyzed in each condition thereafter. For the in vivo studies, MMP-11 expression levels were measured in white adipose tissue(WAT) from C57BL/6J mice that underwent low fat diet or high-fat feeding in order to induce obesity and obesity-related insulin resistance. Statistical analysis was carried out with GraphP ad Prism Software.RESULTS MMP-11 m RNA expression levels were significantly higher in insulin resistant 3T3-L1 adipocytes compared to control cells(1.46±0.49vs0.83±0.21, respectively;P<0.00036). The increase in MMP-11 expression was observed even in the presence of TNF-α alone(3.79±1.11vs1±0.17, P<0.01) or hypoxia alone(1.79±0.7vs0.88±0.1, P<0.00023). The results obtained in in vitro experiments were confirmed in the in vivo model of insulin resistance. In particular, MMP-11 m RNA was upregulated in WAT from obese mice compared to lean mice(5.5±2.8vs1.1±0.7, respectively; P<3.72E-08). The increase in MMP-11 levels in obese mice was accompanied by the increase in typical markers of fibrosis, such as collagen type Ⅵ alpha 3(Col6_α3), and fibroblast-specific protein 1.CONCLUSION Our results indicate that dysregulation of MMP-11 expression is an early process in the adipose tissue dysfunction, which leads to obesity and obesity-related insulin resistance. | Biagio Arcidiacono Eusebio Chiefari Anna Elisa Laria Sebastiano Messineo Francesco Luciano Bilotta Domenico Britti Daniela Patrizia Foti Anna Foryst-Ludwig Ulrich Kintscher Antonio Brunetti | 2017 | World Journal of Diabetes2017，8，9： | 1 |
| 12 | Measures of marketing performance: a comparative study from Spain显示文摘 | Rossano Eusebio Joan Llonch Andreu M. Pilar López Belbeze | 2006 | International Journal of Contemporary Hospitality Management2006，，2： | 1 |
| 13 | Anticoagulation in elderly patients at high risk of atrial fibrillation without documented arrhythmias显示文摘 | Manuel Martinez-Selles Eusebio Garcia-Izquierdo Jaen Ignacio Fernandez Lozano | 2017 | Journal of Geriatric Cardiology2017，14，3： | 1 |
| 14 | Solitary perirenal metastasis from a malignant peripheral nerve sheath tumor mimicking a primary renal tumour显示文摘 | Figueiras RG Eusebio M | 2003 | Australasian Radiology2003，47，2： | 1 |
| 15 | Movement-related changes in local and long-range synchronization in Parkinson J s disease revealed by simultaneous magnetoencephalography and intracranial recordings 显示文摘 | Litvak V Eusebio A Jha A | 2012 | J Neurosci2012，32，10： | 1 |
| 16 | Assessment of cortico-spinal tract impairment in multiple system atrophy using transcranial magnetic stimulation显示文摘 | Eusebio A Azulay JP Witjas T | 2007 | Clin Neurophysiol2007，118，4： | 1 |
| 17 | Deep brain stimulation can suppress pathological synchronisa- tion in parkinsonian patients 显示文摘 | EUSEBIO A THEVATHASAN W GAYNOR L D | 2011 | J Neurol Neurosurg Psychi- atry2011，82，5： | 1 |
| 18 | Resonance in subthalamocortical circuits in Parkinson's disease显示文摘 | Eusebio A Pogosyan A Wang S | 2009 | Brain2009，132，： | 1 |
| 19 | Measures of Marketing Performance: A Comparative Study from Spain 显示文摘 | R Eusebio J L Andreu | 2006 | International Journal of Contemporary Hospitality Management2006，18，2： | 1 |
| 20 | Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling显示文摘 | Susann Weissmueller Eusebio Manchado Michael Saborowski John P. Morris Elvin Wagenblast Carrie A. Davis Sung-Hwan Moon Neil T. Pfister Darjus F. Tschaharganeh Thomas Kitzing Daniela Aust Elke K. Markert Jianmin Wu Sean M. Grimmond Christian Pilarsky Carol | 2014 | Cell2014，，： | 1 |
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