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| 1 | miR-133 and miR-30 Regulate Connective Tissue Growth Factor: Implications for a Role of MicroRNAs in Myocardial Matrix Remodeling显示文摘 | Rudy F. Duisters Anke J. Tijsen Blanche Schroen Joost J. Leenders Viola Lentink Ingeborg van der Made Veronica Herias Rick E. van Leeuwen Mark W. Schellings Paul Barenbrug Jos G. Maessen Stephane Heymans Yigal M. Pinto Esther E. Creemers | 2009 | Circulation Research2009，，： | 2 |
| 2 | The impact of pastoralist mobility on tuberculosis control in Ethiopia:a systematic review and meta-synthesis显示文摘Background:Directly observed treatment,short-course(DOTS)is the current mainstay to control tuberculosis(TB)worldwide.Context-specific adaptations of DOTS have impending implications in the fight against TB.In Ethiopia,there is a national TB control programme with the goal to eliminate TB,but uneven distribution across lifestyle gradients remains a challenge.Notably,the mobile pastoralist communities in the country are disproportionately left uncovered.The aim of this study was to summarize the evidence base from published literature to guide TB control strategy for mobile pastoralist communities in Ethiopia.Main text:We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines and systematically reviewed articles in seven electronic databases:Excerptra Medical Database,African Journal Online,PubMed,Google Scholar,Centre for Agriculture and Bioscience International Direct,Cochrane Library and Web of Science.The databases were searched from inception to December 31,2018,with no language restriction.We screened 692 items of which 19 met our inclusion criteria.Using a meta-ethnographic method,we identified six themes:(i)pastoralism in Ethiopia;(ii)pastoralists’livelihood profile;(iii)pastoralists’service utilisation;(iv)pastoralists’knowledge and awareness on TB control services;(v)challenges of TB control in pastoral settings;and(vi)equity disparities affecting pastoralists.Our interpretation triangulates the results across all included studies and shows that TB control activities observed in pastoralist regions of Ethiopia are far fewer than elsewhere in the country.Conclusions:This systematic review and meta-synthesis shows that TB control in Ethiopia does not align well with the pastoralist lifestyle.Inaccessibility and lack of acceptability of TB care are the key bottlenecks to pastoralist TB service provision.Targeting these two parameters holds promise to enhance effectiveness of an intervention. | Faisal Nooh Lisa Crump Abdiwahab Hashi Rea Tschopp Esther Schelling Klaus Reither Jan Hattendorf Seid M.Ali Brigit Obrist Jurg Utzinger Jakob Zinsstag | 2019 | Infectious Diseases of Poverty2019，8，5： | 2 |
| 3 | Ecological and behavioural risk factors of scrub typhus in central Vietnam:a case-control study显示文摘Background The risk factors for scrub typhus in Vietnam remain unknown.Scrub typhus caused by Orientia tsutsugamushi often presents as an undifferentiated febrile illness and remains under appreciated due to the limited availability of diagnostic tests.This tropical rickettsial illness is increasingly recognized as an important cause of non-malaria acute undifferentiated fever in Asia.This study aimed to investigate behavioural and ecological related risk factors of scrub typhus to prevent this potentially life-threatening disease in Vietnam.Methods We conducted a clinical hospital-based active surveillance study,and a retrospective residence-enrolment date-age-matched case–control study in Khanh Hoa province,Vietnam,from August 2018 to March 2020.Clinical examinations,polymerase chain reaction and enzyme-linked immunosorbent assay IgM tests were applied to define cases and controls.All enrolled participants filled out a questionnaire including demographic socio-economic status,personal behaviors/protective equipment,habitat connections,land use,and possible exposure to the vector.Multivariable conditional logistic regression was used to define the scrub typhus associated risk factors.Results We identified 44 confirmed cases and matched them with 152 controls.Among cases and controls,the largest age group was the 41–50 years old and males accounted for 61.4%and 42.8%,respectively.There were similarities in demographic characteristics between the two groups,with the exception of occupation.Several factors were significantly associated with acquisition of scrub typhus,including sitting/laying directly on household floor[adjusted OR(aOR)=4.9,95%CI:1.6–15.1,P=0.006],household with poor sanitation/conditions(aOR=7.9,95%CI:1.9–32.9,P=0.005),workplace environment with risk(aOR=3.0,95%CI:1.2–7.6,P=0.020),always observing mice around home(aOR=3.7,95%CI:1.4–9.9,P=0.008),and use of personal protective equipment in the field(aOR=0.4,95%CI:0.1–1.1,P=0.076).Conclusions Ecological and household hygiene-related factors were more associated with scrub typhus infection,than individual-level exposure activities in the hyper-endemic area.These findings support local education and allow people to protect themselves from scrub typhus,especially in areas with limitations in diagnostic capacity. | Hanh Thi Duc Tran Jan Hattendorf Hung Manh Do Thanh Tien Hoang Hang Thi Hai Hoang Hoa Ngoc Lam Mai Kim Huynh Lan Thi Hoang Vu Jakob Zinsstag Daniel Henry Paris Esther Schelling | 2021 | Infectious Diseases of Poverty2021，10，4： | 1 |
| 4 | miR-133 and miR-30 Regulate Connective Tissue Growth Factor: Implications for a Role of MicroRNAs in Myocardial Matrix Remodeling显示文摘 | Rudy F. Duisters Anke J. Tijsen Blanche Schroen Joost J. Leenders Viola Lentink Ingeborg van der Made Veronica Herias Rick E. van Leeuwen Mark W. Schellings Paul Barenbrug Jos G. Maessen Stephane Heymans Yigal M. Pinto Esther E. Creemers | 2009 | Circulation Research2009，，2： | 1 |
| 5 | Social Services for Mobile Pastoralists: Cross-sector Strategy Based on "One Health"显示文摘 | Mahamat Bechir Zinsstag Jakob Mahamat Abdoulaye Schelling Esther Kessely Hamit Fokou Gilbert Moto Daugla Bonfoh Bassirou Tanner Marcel | 2012 | Journal of Sociology Study2012，2，9： | 0 |
| 6 | 较大直肠腺瘤中经肛门内镜显微手术与内镜下黏膜切除术的随机对照试验(TREND研究)显示文摘摘要 目的 非随机研究表明内镜下黏膜切除术(endoscopic mucosal resection,EMR)在切除直肠较大腺瘤时与经肛门内镜显微手术(transanal endoscopic microsurgery,TEM)同样有效,但EMR可能更具成本效益且相对安全。本试验旨在对比摘除较大直肠腺瘤时EMR与TEM的临床结局与成本效益。 | Renee M Barendse Gijsbert D Musters Eelco J R de Graaf Frank J C van den Broek Esther C J Consten Pascal G Doornebosch James C Hardwick Ignace H J T de Hingh Chrisiaan Hoft Jeroen M Jansen A W Marc van Milligen de Wit George P van der Schelling Erik J Schoon Matthijs P Schwartz Bas L A M Weusten Marcel G Dijkgraaf Paul Fockens Willem A Bemelman Evelien Dekker TREND研究小组 李佳宁(译) 吴东(校) | 2018 | 英国医学杂志中文版2018，21，11： | 0 |
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