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| 1 | Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers显示文摘AIM:To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori(H.pylori)-associated,non-steroidal inflammatory drug(NSAID)-associated and idiopathic-gastric ulcers.METHODS:We studied a cohort of randomly selected patients with H.pylori(group 1,n=30),NSAID(group 2,n=18),combined H.pylori and NSAID associated gastric ulcers(group 3,n=24),and patients with idiopathic gastric ulcers(group 4,n=20).Immunohistochemistry for MUC1,MUC4,MUC17,and staining for Erythrina cristagalli agglutinin and Sambucus nigra agglutinin(SNA)lectins was performed on sections from the ulcer margins.RESULTS:Staining intensity of MUC17 was higher in H.pylori ulcers(group 1)than in idiopathic ulcers(group4),11.05±3.67 vs 6.93±4.00 for foveola cells,and10.29±4.67 vs 8.00±3.48 for gland cells,respectively(P<0.0001).In contrast,MUC1 expression was higher in group 4 compared group 1,9.89±4.17 vs 2.93±5.13 in foveola cells and 7.63±4.60 vs 2.57±4.50 for glands,respectively(P<0.0001).SNA lectin staining was increased in group 4,in parallel to elevated MUC1expression,indicating more abundantα2-6 sialylation in that group.CONCLUSION:Cytoplasmic MUC17 staining was sig-nificantly decreased in the cases with idiopathic ulcer.The opposite was observed for both MUC1 and SNA lectin.This observation may reflect important pathogenic mechanisms,since different mucins with altered sialylation patterns may differ in their protection efficiency against acid and pepsin. | Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 2 | Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes显示文摘AIM:To investigate the role of protein tyrosine phosphorylation in gastric wound formation and repair following ulceration. METHODS:Gastric lesions were induced in rats using restraint cold stress.To investigate the effect of oxidative and nitrosative cell stress on tyrosine phosphorylation during wound repair,total activity of protein tyrosine kinase(PTK),protein tyrosine phosphatase (PTP),antioxidant enzymes,nitric oxide synthase (NOS), 2',5'-oligoadenylate synthetase,hydroxyl radical and zinc levels were assayed in parallel. RESULTS:Ulcer provocation induced an immediate decrease in tyrosine kinase(40% in plasma membranes and 56% in cytosol,(P<0.05) and phosphatase activity (threefold in plasma membranes and 3.3-fold in cytosol),followed by 2.3-2.4-fold decrease (P<0.05) in protein phosphotyrosine content in the gastric mucosa. Ulceration induced no immediate change in superoxide dismutase (SOD) activity,30% increase (P<0.05) in catalase activity,2.3-fold inhibition (P<0.05) of glutathione peroxidase,3.3-fold increase (P<0.05) in hydroxyl radical content,and 2.3-fold decrease (P<0.05) in zinc level in gastric mucosa.NOS activity was three times higher in gastric mucosa cells after cold stress. Following ulceration,PTK activity increased in plasma membranes and reached a maximum on day 4 after stress (twofold increase,P<0.05),but remained inhibited(1.6-3-fold decrease on days 3,4 and 5,P<0.05) in the cytosol.Tyrosine phosphatases remained inhibited both in membranes and cytosol(1.5-2.4-fold,P< 0.05).NOS activity remained increased on days 1,2 and 3(3.8-,2.6-,2.2-fold,respectively,P<0.05).Activity of SOD increased 1.6 times(P<0.05)days 4 and 5 after stress.Catalase activity normalized after day 2. Glutathione peroxidase activity and zinc level decreased (3.3-and 2-fold,respectively,P<0.05)on the last day. Activity of 2',5'-oligoadenylate synthethase increased 2.8-fold (P<0.05) at the beginning,and 1.6-2.3-fold (P<0.05) during ulcer recuperation,and normalized on day 5,consistent with slowing of inflammation processes. CONCLUSION:These studies show diverse changes in total tyrosine kinase activity in gastric mucosa during the recovery process.Oxidative and nitrosative stress during lesion formation might lead to the observed reduction in tyrosine phosphorylation during ulceration. | Olena V Bogdanova Larysa I Kot Kateryna V Lavrova Volodymyr B Bogdanov Erica K Sloan Tetyana V Beregova Ludmyla I Ostapchenko | 2010 | World Journal of Biological Chemistry2010，1，11： | 2 |
| 3 | Effects of herbivory on the reproductive effort of 4 prairie显示文摘 | Erica S Kate L B Johannes M H K | 2002 | BMC Ecology2002，2，： | 1 |
| 4 | Simultaneous determination of serum concentrations of levodopa, dopamine, 3 - O - methyldopa and α- methyldopa by HPLC显示文摘 | Chiara M Erica B Lucia T | 2008 | Biomed Pharm2008，62，4： | 1 |
| 5 | Endothelial stress by gravitational unloading:effects on cell growth and cytoskeletal organization显示文摘 | Sofia IM Maria TS Erica B | 2003 | Biochimica & Biophysica Acta2003，1642，： | 1 |
| 6 | Inflammation enhances myeloid-derived suppressor cell crosstalk by signaling through Toll-like receptor 4显示文摘 | STEPHANIE K B VIRGINIA K C ERICA M H | 2009 | J Leukoc Biol2009，85，： | 1 |
| 7 | Rapid influenza antigen test for diagnosis of pandemic(H1N1) 2009显示文摘 | Janice K Louie HG Erica B | 2010 | Emerg Infect Dis2010，16，5： | 1 |
| 8 | Unsupportive Responses from Others Concerning a Stressful Life Event:Development of the Unsupportive Social Interactions Inventory 显示文摘 | Kathleen M I Naney E B Erica J M | 2001 | Journal of Social and Clinical Psychology2001，20，： | 1 |
| 9 | Rapid ammonium and nitrate-induced pertur-bations to chl a fluorescence in nitrogen-stressed Dunaliella tertiolec-ta(Chlorophyta)显示文摘 | Erica B Beardal1 J | 2003 | J Phyco12003，39，： | 1 |
| 10 | Diagnosis and Management of Symptomatic Hemorrhoids显示文摘 | Erica B | 2010 | Surgical Clinics of North America2010，1，： | 1 |
| 11 | Unsupportive responses from others concerning a stressful life event:Development of the unsupportive social interactions inventory显示文摘 | Kathleen M I Nancy E B Erica J M | 2001 | Journal of Social and Clinical Psychology2001，20，2： | 1 |
| 12 | Late onset renal allograft anastomotic pseudoaneutysm with absent Doppler signal显示文摘 | John G B Zarrin S Erica G | 1992 | J Urol1992，148，12： | 1 |
| 13 | Full-mouth untra- sonic dehridement associated with amoxicillin and metron- idazole in the treatment of severe chronic periodontitis 显示文摘 | Erica DPR Sandro B Iriana CJZ | 2009 | J Periodontol2009，80，8： | 1 |
| 14 | Low-temperature solid-oxide fuel cells utilizing thin bilayer electrolytes 显示文摘 | TSEPIN T ERICA P SCOTT B | 1997 | J Electrochem Soc1997，144，： | 1 |
| 15 | Scientific mis- conduct from the perspective of research coordinators : a na- tional survey显示文摘 | ERICA R P BARBARA H MARION E B | 2007 | Med Ethics2007，，33： | 1 |
| 16 | Use of cholecystostomy tubes in the management of patients with primary diagnosis of acute cholecystitis显示文摘 | Nicole Cherng Elan T Witkowski Erica B | | 0，，02： | 1 |
| 17 | Metabolic determinants of defibrillation显示文摘 | Bruce B Lerman Erica D Engelstein | 1995 | Circulation1995，91，： | 1 |
| 18 | Measurement of Human Metabolism显示文摘 | Robert B Erica W Jon M | 2010 | IEEE Engineering in Medicine and Biology Magazine2010，7，： | 1 |
| 19 | Fracture resistance of roots endodontically treated with a new resin filling material显示文摘 | Fabricio B Erica C Jeffrey Y | 2004 | J Am Dent Assoc2004，135，5： | 1 |
| 20 | Approaches for determining phytoplankton nutrient limitation显示文摘 | JOHN B ERICA Y SIMON R | 2001 | Aquatic Sciences2001，63，： | 1 |
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