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| 1 | Current and future treatments for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) represents a unique challenge for physicians and patients.There is no definitively curative treatment.Rather,many treatment and management modalities exist with differing advantages and disadvantages.Both current guidelines and individual patient concerns must be taken into account in order to properly manage HCC.In addition,quality of life issues are particularly complex in patients with HCC and these concerns must also be factored into treatment strategies.Thus,considering all the options and their various pros and cons can quickly become complex for both clinicians and patients.In this review,we systematically discuss the current treatment modalities available for HCC,detailing relevant clinical data,risks and rewards and overall outcomes for each approach.Surgical options discussed include resection,transplantation and ablation.We also discuss the radiation modalities:conformal radiotherapy,yttrium 90 microspheres and proton and heavy ion radiotherapy.The biologic agent Sorafenib is discussed as a promising new approach,and recent clinical trials are reviewed.We then detail currently described molecular pathways implicated in the initiation and progression of HCC,and we explore the potential of each pathway as an avenue for drug exploitation.We hope this comprehensive and forward-looking review enables both clinicians and patients to understand various options and thereby make more informed decisions regarding this disease. | Alexander Schlachterman Willie W Craft Jr Eric Hilgenfeldt Avir Mitra Roniel Cabrera | 2015 | World Journal of Gastroenterology2015，21，28： | 76 |
| 2 | Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections显示文摘Selection of the appropriate donor is essential to a successful allograft recipient outcome for solid organ transplantation. Multiple infectious diseases have been transmitted from the donor to the recipient via transplantation. Donor-transmitted infections cause increased morbidity and mortality to the recipient. In recent years, a series of high-profile transmissions of infections have occurred in organ recipients prompt-ing increased attention on the process of improving the selection of an appropriate donor that balances the shortage of needed allografts with an approach that mitigates the risk of donor-transmitted infection to the recipient. Important advances focused on improving donor screening diagnostics, using previously excluded high-risk donors, and individualizing the selection of allografts to recipients based on their prior infection history are serving to increase the donor pool and improve outcomes after transplant. This article serves to review the relevant literature surrounding this topic and to provide a suggested approach to the selection of an appropriate solid organ transplant donor. | Christopher S Kovacs Jr Christine E Koval David van Duin Amanda Guedes de Morais Blanca E Gonzalez Robin K Avery Steven D Mawhorter Kyle D Brizendine Eric D Cober Cyndee Miranda Rabin K Shrestha Lucileia Teixeira Sherif B Mossad | 2014 | World Journal of Transplantation2014，4，2： | 7 |
| 3 | Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed. | Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 4 | Management of Patients With Atrial Fibrillation: A Statement for Healthcare Professionals From the Subcommittee on Electrocardiography and Electrophysiology, American Heart Association显示文摘 | Eric N. Prystowsky Jr Benson Valentin Fuster Robert G. Hart G. Neal Kay Robert J. Myerburg Gerald V. Naccarelli D. George Wyse | 1996 | Circulation1996，，6： | 2 |
| 5 | Effect of Spreader and Accessory Cone Size on Density of Obturation Using Conventional or Mechanical Lateral Condensation 显示文摘 | Tom GG Richard JR Eric CO | 2001 | Journal of Endodontics2001，27，5： | 1 |
| 6 | Long-term study of temporomandibular joint surgery with alloplastic implants compares with nonimplant surgery and nonsurgecal rehabilitation for painful temporomandibular joint disc displacement 显示文摘 | Friction JR John O Eric S | 2002 | J Oral Maxillofac Surg2002，60，12： | 1 |
| 7 | Coronary Heart Disease/Thrombosis/Myocardial-Infarction: Marked Inflammatory Sequelae to Implantation of Biodegradable and Nonbiodegradable Polymers in Porcine Coronary Arteries显示文摘 | Willem J. van der Giessen A. Michael Lincoff Robert S. Schwartz Heleen M.M. van Beusekom Patrick W. Serruys David R. Jr Holmes Stephen G. Ellis Eric J. Topol | 1996 | Circulation1996，，7： | 1 |
| 8 | Calvarial an Skull Base Metastasis:Comparison of Nonenhanced and Gd-DTPA enhanced MR Imagings显示文摘 | Michele SW Eric JR Robert Breit | 1990 | Radiology1990，174，1： | 1 |
| 9 | A methodological approach and framework for sustainahility assessment in NGO-implemented primary health care programs显示文摘 | Eric GS Peter JW Leo JR | 2004 | Int J Health Planning Mgmt2004，19，： | 1 |
| 10 | Qualitative research to make practical sense of sustainability in primary health care projects implemented by non-governmental organizations显示文摘 | Eric GS Peter JW Leo JR | 2004 | Int J Health Plann Mgmt2004，19，： | 1 |
| 11 | Diagnositic Test for Patients with Suspected Allergic Disease Utility and Limitation显示文摘 | Paul P VanArsdel Jr M Eric B | 1989 | Annals of Internal Medicine1989，110，4： | 1 |
| 12 | Cholera transmission:the host,pathogen and bacteriophage dynamic显示文摘 | Eric J Nelson Jason B Harris J Glenn Morris Jr | 2009 | Journal Reviews Microbiology2009，7，： | 1 |
| 13 | On the Impact of WRF Model Vertical Grid Resolution on Midwest Summer Rainfall Forecasts 显示文摘 | Eric A ALIGO William A Gallus Jr | 2009 | Weather and Forecasting2009，，24： | 1 |
| 14 | High-g power sources for the US army's HSTTS programmer显示文摘 | Lawrence W Burke Jr Eric S Irwin Raymond Faulstich | 1997 | Journal of power sources1997，65，： | 1 |
| 15 | Racial/ethnic disparities in hepatocellular carcinoma treatment and survival in California, 1988-2012显示文摘AIM To describe racial/ethnic differences in treatment and survival among liver cancer patients in a populationbased cancer registry.METHODS Invasive cases of primary hepatocellular carcinoma, n = 33270, diagnosed between January 1, 1988-December 31, 2012 and reported to the California Cancer Registry were analyzed by race/ethnicity, age, gender, geographical region, socio-economic status, time period of diagnosis, stage, surgical treatment, and survival. Patients were classified into 15 racial/ethnic groups: non-Hispanic White(White, n = 12710), Hispanic(n = 8500), Chinese(n = 2723), non-Hispanic Black(Black, n = 2609), Vietnamese(n = 2063), Filipino(n = 1479), Korean(n = 1099), Japanese(n = 658), American Indian/Alaskan Native(AIAN, n = 281), Laotian/Hmong (n = 244), Cambodian(n = 233), South Asian(n = 190), Hawai`ian/Pacific Islander(n = 172), Thai(n = 95), and Other Asian(n = 214). The main outcome measures were receipt of surgical treatment, and cause-specific and all-cause mortality.RESULTS After adjustment for socio-demographic characteristics, time period, and stage of disease, compared to Whites, Laotian/Hmong [odds ratio(OR) = 0.30, 95%CI: 0.17-0.53], Cambodian(OR = 0.65, 95%CI: 0.45-0.96), AIAN(OR = 0.66, 95%CI: 0.46-0.93), Black(OR = 0.76, 95%CI: 0.67-0.86), and Hispanic(OR = 0.78, 95%CI: 0.72-0.84) patients were less likely, whereas Chinese(OR = 1.58, 95%CI: 1.42-1.77), Koreans(OR = 1.45, 95%CI: 1.24-1.70), Japanese(OR = 1.41, 95%CI: 1.15-1.72), and Vietnamese(OR = 1.26, 95%CI: 1.12-1.42) were more likely to receive surgical treatment. After adjustment for the same covariates and treatment, cause-specific mortality was higher for Laotian/Hmong [(hazard ratio(HR) = 1.50, 95%CI: 1.29-1.73)], Cambodians(HR = 1.35, 95%CI: 1.16-1.58), and Blacks(HR = 1.07, 95%CI: 1.01-1.13), and lower for Chinese(HR = 0.82, 95%CI: 0.77-0.86), Filipinos(HR = 0.84, 95%CI: 0.78-0.90), Vietnamese(HR = 0.85, 95%CI: 0.80-0.90), Koreans(HR = 0.90, 95%CI: 0.83-0.97), and Hispanics(HR = 0.91, 95%CI: 0.88-0.94); results were similar for all-cause mortality.CONCLUSION Disaggregated data revealed substantial racial/ethnic differences in liver cancer treatment and survival, demonstrating the need for development of targeted interventions to mitigate disparities. | Susan L Stewart Sandy L Kwong Christopher L Bowlus Tung T Nguyen Annette E Maxwell Roshan Bastani Eric W Chak Moon S Chen Jr | 2016 | World Journal of Gastroenterology2016，22，38： | 1 |
| 16 | Stab and puncture characterization of thermoplastic- impregnated aramid fabric显示文摘 | Jessie B Mayo Jr Eric D W | 2009 | International Journal of Impact Engineering2009，36，9： | 1 |
| 17 | Dual-phase helical CT of locally invasive pancreatic adenocarcinoma显示文摘 | Eric WO Brooke JR | 1998 | J Computed Assist Tomogr1998，22，： | 1 |
| 18 | Shoot,but not root,competition reduces community diversity in experimental mesocosms显示文摘 | Eric G Lamb Steven W Kembel James F Cahill Jr | 2009 | Journal of Ecology2009，97，： | 1 |
| 19 | Patterns of cooperation during new product development among marketing,operations and R&D:Implications for project performance显示文摘 | Eric M.Olson Orville C.Walker Jr Robert W.Ruekertc Joseph M.Bonner | | 0，，： | 1 |
| 20 | Impaired insulin and insulin-like grouth factor expression and signling mechanisms in Alzheimer's disease-is this type 3 diabetes?显示文摘 | Eric SA Benjamin MT Enrique JR | 2005 | J Alzheimer''s Disease2005，7，： | 1 |
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