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| 1 | Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction显示文摘AIM:To investigate the molecular mechanism and functional consequences of heme oxygenase-1(HO-1) activation by lansoprazole in endothelial cells and macrophages. METHODS:Expression of HO-1 mRNA was analyzed by Northern blotting.Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-dependent reactive oxygen species(ROS) formation was measured with lucigenin-enhanced chemiluminescence.HO-1 promoter activity in mouse fibroblasts,stably transfected with a 15-kb HO-1 gene that drives expression of the reporter gene luciferase, was assessed using in vivo bioluminescence imaging. RESULTS:Lansoprazole increased HO-1 mRNA levels in endothelial cells and HO-1 protein levelsin macrophages.In addition,lansoprazole-induced ferritin protein levels in both cell systems.Moreover, induction of the antioxidant proteins HO-1 and ferritin by lansoprazole was followed by a decrease in NADPH- mediated ROS formation.The radical scavenging properties of lansoprazole were diminished in the presence of the HO inhibitor,chromium mesoporphyrin IX.Induction of HO-1 gene expression by lansoprazole was not related to oxidative stress or to the activation of the mitogen-activated protein kinase pathway. However,the phosphatidylinositol 3-kinase inhibitor LY294002 showed a concentration-dependent inhibition of HO-1 mRNA and promoter activity. CONCLUSION:Activation of HO-1 and ferritin may account for the gastric protection of lansoprazole and is dependent on a pathway blocked by LY294002. | Stephanie Schulz-Geske Kati Erdmann Ronald J Wong David K Stevenson Henning Schrder Nina Grosser | 2009 | World Journal of Gastroenterology2009，15，35： | 7 |
| 2 | 成人隐匿阴茎治疗的综述显示文摘背景与目的导致隐匿阴茎的原因很多,最常见的是肥胖、包皮环切术后或阴囊水肿。随着肥胖病日益增多,这种病症的发病率也必然增多。儿童先天性隐匿阴茎极为罕见,其结果也是转变成为成人隐匿阴茎。本文的目的旨在综述目前对于此类身心疾患的治疗策略。方法对有关隐匿阴茎治疗的文献进行综述,文献主要来源是1977年至2007年PubMed中刊登的整形外科和泌尿外科文献。结果病态肥胖症和糖尿病是成人隐匿阴茎的危险因素。文献中介绍了多种复位和重建的手术方法,如原位缝合、Z成形、植皮修复等,修复过程中均可能进行脂肪切除。最近的文献更多关注采用断层皮片和负压技术进行治疗,该技术有利于皮片成活,远期美观效果良好。结论隐匿阴茎临床少见,治疗困难,对于整形科和泌尿外科医师具有挑战性。潜在因素如病态肥胖和糖尿病的增加,提示这种疾病的发生率也将不断上升。没有某一特定的技术适用于所有患者,治疗时可以采用几种技术的联合。对于疑难重症患者,可以进行阴茎体断层皮片移植术、阴囊缩小术,并可辅助负压吸脂术或脂肪切除术。个体化治疗方法可以获得更高的修复成功率,并且达到满意的美观效果。 | Ivo A. Pestana Jason M. Greenfield Mark Walsh Craig F. Donatucci Detlev Erdmann 冯爱娜 陶凯 魏峰 高景恒 张晨 | 2012 | 中国美容整形外科杂志2012，23，5： | 5 |
| 3 | Polypropylene composites with enzyme modified abaca fibre显示文摘 | Andrzej K. Bledzki Abdullah A. Mamun Adam Jaszkiewicz Karsten Erdmann | 2010 | Composites Science and Technology2010，，5： | 2 |
| 4 | The effect of cardiac resynchronization on morbidity and mortality in heart failure显示文摘 | Cleland JG Daubert JC Erdmann E | 2005 | N Engl J Med2005，352，15： | 1 |
| 5 | The effect of cardiac resynchronization on morbidity and mortality in heart failure 显示文摘 | Cleland JGF Daubert JC Erdmann E | 2005 | N Engl J Med2005，352，： | 1 |
| 6 | The possible roles of food derived bioaefive peptides in reducing the risk of cardiovascular disease显示文摘 | ERDMANN K CHEUNG B W Y SCHRODER H | 2008 | Journal of Nutritional Biochemistry2008，19，10： | 1 |
| 7 | Sunrise model and the sensitive reason in nursing显示文摘 | Erdtmann B K Erdmann A L | 2003 | Rev Bras Enferm2003，56，5： | 1 |
| 8 | The effect of cardiac resynchronization onmortality on mortality in heart failure显示文摘 | Cleland JG Daubert JC Erdmann E | 2005 | N Engl J Med2005，352，15： | 1 |
| 9 | The effect of car- diac resynchronization on morbidity and mortality in heart failure 显示文摘 | Cleland JG Daubert JC Erdmann E | 2005 | N Engl J Med2005，352，15： | 1 |
| 10 | A realistic complication analysis of 70 sural artery flaps in a multi-morbid patient group显示文摘 | Baumeister SP Spierer R Erdmann D | 2003 | Plast Reconstr Surg2003，112，1： | 1 |
| 11 | The effect of cardiac resynchronization on morbidity and mortality in heart failure 显示文摘 | Cleland JG Daubert JC Erdmann E | 2005 | N Engl J Med2005，352，15： | 1 |
| 12 | The effect of cardiac resynchronization on morbidity and mortality in heart failure显示文摘 | Cleland JG Daubert JC Erdmann E | 2005 | N Engl J Med2005，352，15： | 1 |
| 13 | beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin 显示文摘 | Huelsken J Vogel R Erdmann B | 2001 | Cell2001，105，4： | 1 |
| 14 | Design of antisense oligonucleotides stabilized by locked nucleic acids显示文摘 | KURRECK J WYSZKO E GILLEN C ERDMANN V A | 2002 | Nucleic Acid Res2002，30，9： | 1 |
| 15 | A yeast-based functional assay for the detection of the mutant androgen receptor in prostate cancer 显示文摘 | Ceraline J Erdmann E Erbs P | 2003 | Eur J Endocrinol2003，148，1： | 1 |
| 16 | Diagnostic tests based on human basophils : potentials, pitfalls and perspectives 显示文摘 | Kleine-Tebbe J Erdmann S Knol E F | 2006 | Int Arch Allergy Immunol2006，141，1： | 1 |
| 17 | A new frontier for molecular medicine: noncoding RNAs显示文摘 | Szymanski M Barciszewska MZ Erdmann VA | 2005 | Biochim Biophys Acta2005，1756，1： | 1 |
| 18 | The effect of cardiacresynchronization on morbidity and mortality in heart failure显示文摘 | Cleland J G Daubert J C Erdmann E | 2005 | N Engl JMed2005，352，15： | 1 |
| 19 | The effect of cardiac resynchroni- zation on morbidity and mortality in heart failure 显示文摘 | Cleland JGF Daubert JC Erdmann E | 2005 | N Engl J Med2005，352，： | 1 |
| 20 | beta-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin显示文摘 | Huelsken J Vogel R Erdmann B | 2001 | Cell2001，105，4： | 1 |
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