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| 1 | Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis显示文摘AIM:To analyze phospholipid profiles in intrahepatic bile from patients with primary sclerosing cholangitis(PSC)and secondary sclerosing cholangitis(SSC).METHODS:Intrahepatic bile specimens collected via endoscopic retrograde cholangiography from 41 patients were analyzed.Fourteen of these patients were diagnosed with PSC,10 with SSC,11 with choledocholithiasis or no identifiable biliary disease,and 6 with cholangiocellular carcinoma(CCC).Bile acid,cholesterol,protein,and bilirubin contents as well as pancreas lipase activity in bile were determined by biochemical methods.Phosphatidylcholine(PC)and lysophosphatidylcholine(LPC)species were quantified using nanoelectrospray ionization tandem mass spectrometry.RESULTS:Bile from all the examined patient groups showed a remarkably similar PC and LPC species composition,with only minor statistical differences.Total biliary PC concentrations were highest in controls(8030±1843 mol/L)and lowest in patients with CCC(1969±981 mol/L)(P=0.005,controls vs SSC and CCC,respectively,P<0.05).LPC contents in bile were overall low(4.2%±1.8%).Biliary LPC/PC ratios and ratios of biliary PC to bilirubin,PC to cholesterol,PC to protein,and PC to bile acids showed no intergroup differences.CONCLUSION:PC and LPC profiles being similar in patients with or without sclerosing cholangitis,these phospholipids are likely not of major pathogenetic importance in this disease group. | Annika Gauss Robert Ehehalt Wolf-Dieter Lehmann Gerhard Erben Karl-Heinz Weiss Yvonne Schaefer Petra Kloeters-Plachky Adolf Stiehl Wolfgang Stremmel Peter Sauer Daniel Nils Gotthardt | 2013 | World Journal of Gastroenterology2013，19，33： | 3 |
| 2 | Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap显示文摘The use of optical tweezers to measure forces acting upon microscopic particles has revolutionised fields from material science to cell biology.However,despite optical control capabilities,this technology is highly constrained by the material properties of the probe,and its use may be limited due to concerns about the effect on biological processes.Here we present a novel,optically controlled trapping method based on light-induced hydrodynamic flows.Specifically,we leverage optical control capabilities to convert a translationally invariant topological defect of a flow field into an attractor for colloids in an effectively one-dimensional harmonic,yet freely rotatable system.Circumventing the need to stabilise particle dynamics along an unstable axis,this novel trap closely resembles the isotropic dynamics of optical tweezers.Using magnetic beads,we explicitly show the existence of a linear force-extension relationship that can be used to detect femtoNewton-range forces with sensitivity close to the thermal limit.Our force measurements remove the need for laser-particle contact,while also lifting material constraints,which renders them a particu-larly interesting tool for the life sciences and engineering. | Iliya D.Stoev Benjamin Seelbinder Elena Erben Nicola Maghelli Moritz Kreysing | 2021 | eLight2021，1，1： | 3 |
| 3 | KRAS and BRAF muta-tions and PTEN expression do not predict efficacy of cetuximab-basedchemoradiotherapy in locally advanced rectal cancer显示文摘 | Erben P StrSbel P Horisberger K | 2011 | Int J Radi-at Oncol Biol Phys2011，81，4： | 1 |
| 4 | Extracts of Linderaobtusiloba induce antifibrotic effects in hepatic stellatecells via suppression of a TGF-beta-mediated profibroticgene expression pattern 显示文摘 | Ruehl M Erben U Kim K | 2009 | J Nutr Biochem2009，20，8： | 1 |
| 5 | Impact of Childhood Inguinal Hernia Repair in Adulthood: 50 Years of Follow-UpI显示文摘 | Benjamin Zendejas Abdalla E · Zarroug Young M * Erben | 2010 | Journal of the American College of Surgeons2010，211，6： | 1 |
| 6 | Characterization and Quantification of Rat Bile Phosphatidylcholine by Electrospray–Tandem Mass Spectrometry显示文摘 | Wolf D. Lehmann Martin Koester Gerhard Erben Dietrich Keppler | 1997 | Analytical Biochemistry1997，，1： | 1 |
| 7 | Impact of childhood inguinal Hernia repair in adulthood:50 years of folloeup显示文摘 | Zendejas B Zarroug AE Erben YM | 2010 | J Am Coll Surg2010，211，6： | 1 |
| 8 | Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D显示文摘 | Erben R G Soegiarto D W Weber K | 2002 | Mol Endocrinol2002，16，： | 1 |
| 9 | Non-covalent single transcription factor encapsulation inside a DNA cage 显示文摘 | Crawford R Erben C M Periz J | 2013 | Angewandte Chemie International Edition2013，52，8： | 1 |
| 10 | Harmonization of molecular monitoring of CML therapy in Europe显示文摘 | Müller MC Cross NC Erben P | | 0，，11： | 1 |
| 11 | Screening for diverse PDGFRA or PDGFRB fusion genes is facilitated by generic quantitative reverse transcriptase polymerase chain reaction analysis显示文摘 | Erben P Gosenca D Muller MC | 2010 | Haematologica2010，95，5： | 1 |
| 12 | The prevalence of exlended - spectrum beta - latamaze - producing Escherohia eoli and Klebsiella pneumoniae in clinical isolates and risk factors 显示文摘 | Qzx/unes I Erben N Kiremitci A | 2006 | Scan Med J2006，27，5： | 1 |
| 13 | KRAS and BRAF mutation and PETEN expression do not predict efficacy of cetuxiamb-based chemoradiotherapy in locally advanced rectal cancer显示文摘 | Erben P Storbel P Horisberger K | 2011 | Int J Radiat Oncol Biol Phys2011，81，4： | 1 |
| 14 | The prevalence of extended-spectrum beta-latamase-producing Escherchia coli and Klebsiella pneumoniae in clinical isolates and risk factors显示文摘 | Qzqunes I Erben N Kiremitci A | | 0，，05： | 1 |
| 15 | Safety and efficacy of imatinib in chronic eosinophilic leukaemia and hypereosinophilic syndrome:a phase-Ⅱ study显示文摘 | Metzgeroth G Walz C Erben P | | 0，，05： | 1 |
| 16 | Harmonization of molecu-lar monitoring of CML therapy in Europe 显示文摘 | Muller MC Cross NC Erben P | 2009 | Leukemia2009，23，11： | 1 |
| 17 | Extracts of Lindera obtusiloba induce antifibrotic effects in hepatic stellate cells via suppression of a TGF-beta-mediated profibrotic gene expression pattern显示文摘 | RUEHL M ERBEN U KIM K | 2009 | J Nutr Biochem2009，20，8： | 1 |
| 18 | Stability of conversionfactors for BCR-ABL monitoring-implications for the frequencyof validation rounds 显示文摘 | Muller MC Munjal U Erben P | 2010 | Blood (ASH Annual MeetingAbstracts)2010，116，： | 1 |
| 19 | The Relationship between Paternalistic Leadership and Organizational Commitment :Investigating the Role of Climate Regarding Ethics显示文摘 | ERBEN G S GI:NESER A B | 2008 | Journal of Business Ethics2008，82，4： | 1 |
| 20 | Assessment of oxidative status and genotoxicity in photocopier operators: A pilot study 显示文摘 | Kleinsorge E C Erben M Galan M G | 2011 | Biomarkers2011，16，8： | 1 |
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