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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Non-Hodgkin's Lymphoma Presenting with Spinal Epidural Involvement显示文摘 | Epelbaum R Haim N Ben Shahar M | 1986 | Cancer1986，58，9： | 1 |
| 3 | The sensitive period for strabismic amblyopia in humans显示文摘 | Epelbaum M Milleret C Buisseret P | 1993 | Ophthalmology1993，100，3： | 1 |
| 4 | Curcumin as an anti-cancer agent:review of the gap between basic and clinical applications 显示文摘 | Bar-Sela G Epelbaum R Schaffer M | 2010 | Curr Med Chem2010，17，3： | 1 |
| 5 | lSF-FDG avidity in lymphoma readdressed:a study of 766 patients 显示文摘 | Weiler-Sagie M Busheler O Epelbaum R | 2010 | J Nucl ned2010，51，1： | 1 |
| 6 | PVT Growth of Bulk A1N Crystals with Low Oxygen Contamination 显示文摘 | Bickermann M Epelbaum B M Winnacker A | 2003 | Physica Status Solidi (c)2003，7，： | 1 |
| 7 | Edge-defined film-fed growth (EFG) of rare-earth orthovanadates REVO4 (RE=Y,Gd):approaches to attain high quality shaped growth显示文摘 | EPELBAUM B M SHIMAMURA K INABA K | 1999 | Cryst Res Tochnol1999，34，3： | 1 |
| 8 | Incorporating evidence into clinical teaching:enhanced geriatrics specialty case-based residency presentations显示文摘 | Powers JS Cahall M Epelbaum M | 2012 | J Grad Med Educ2012，4，1： | 1 |
| 9 | Comparative Study of Initial Growth Stage in PVT Growth of AlN on SiC and on Native AlN Substrates显示文摘 | Epelbaum B M Heimann P | 2005 | Physica Status Solidi( c)2005，7，2： | 1 |
| 10 | The sensitive period for strabismic amblyopia in humans显示文摘 | Epelbaum M Milleret C Buisseret P | 1993 | Ophthalmology1993，100，3： | 1 |
| 11 | (18)F-FDG avidityin lymphoma readdressed:a study of 766 patients显示文摘 | Weiler-Sagie M Bushelev O Epelbaum R | 2010 | J Nucl Med2010，51，1： | 1 |
| 12 | The sensitive period for strabismic amblyopia in humans显示文摘 | Epelbaum M Milleret C Buisseret P | 1993 | Ophthalmology1993，100，： | 1 |
| 13 | Microstructure of Al2O3/Y3Al5O12 Eutectic Fibers Grown by u- PD Method显示文摘 | Epelbaum B M Yoshikawa A Shimamura K | 1999 | J Cryst Growth1999，，1： | 1 |
| 14 | Natural growth habit of bulk AIN crystals显示文摘 | Epelbaum B M Seitz C Magerl A | 2004 | Journal of Crystal Growth2004，265，34： | 1 |
| 15 | Curcumin and gemcitabine in patients with advanced pancreatic cancer显示文摘 | EPELBAUM R SCHAFFER M VIZEL B | 2010 | Nutr Cancer2010，62，8： | 1 |
| 16 | 18F-FDG avidity in lymphoma readdressed:a study of 766 patients显示文摘 | Weiler-Sagie M Bushelev O Epelbaum R | | 0，，： | 1 |
| 17 | Curcumin as an antieaneer agent: Review of the gap between basic and clinical applications 显示文摘 | Bar-Sela G Epelbaum R Schaffer M | 2010 | Curr Med Chem2010，17，3： | 1 |
| 18 | (18)F-FDGavidity in lymphoma readdressed: a study of 766 patients 显示文摘 | Weiler-Sagie M Bushelev O Epelbaum R | 2010 | J Nucl Med2010，51，1： | 1 |
| 19 | (18)F-FDG avidity in lymphoma readdressed:a study of 766 patients 显示文摘 | Weiler-Sagie M Bushelev O Epelbaum R | 2010 | J Nucl Med2010，51，1： | 1 |
| 20 | Natural growth habit of bulk A1N crystals显示文摘 | B M Epelbaum C Seitz A Magerl | 2004 | Journal of Crystal Growth2004，265，34： | 1 |
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