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| 1 | Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance显示文摘AIM To study the effect of phosphorylation ofMAPK and Stat3 and the expression of c-fos andc-jun proteins on hepatocellular carcinogenesisand their clinical significance.METHODS SP immunohistochemistry was usedto detect the expression of p42/44MAPK, p-Stat3,c-fos and c-jun proteins in 55 hepatocellularcarcinomas (HCC) and their surrounding livertissues.RESULTS The positive rates and expressionlevels of p42/44MAPK, p-Stat3, c-fos and c-junproteins in HCCs were significantly higher thanthose in pericarcinomatous liver tissues (PCLT).A positive correlation was observed between theexpression of p42/44MAPK and c-fos proteins, andbetween p-Stat3 and c-jun, but there was nosignificant correlation between p42/44MAPK and p-Stat3 in HCCs and their surrounding livertissues.CONCLUSION The abnormalities of Ras/Rat/MAPK and JAKs/ Stat3 cascade reaction maycontribute to malignant transformation ofhepatocytes. Hepatocytes which are positive forp42/ 44MAPK, c-fos or c-jun proteins may bepotential malignant pre-cancerous cells.Activation of MAPK and Stat3 proteins may be anearly event in hepatocellular carcinogenesis. | De Yun Feng Hui Zheng Yi Tan Rui Xue Cheng Department of Pathology, Hunan Medical University, Changsha 410078, Hunan Province, China New England Biolab, MA, USA | 2001 | World Journal of Gastroenterology2001，7，1： | 75 |
| 2 | Reflections on theoretical pragmatics显示文摘This paper provides a critical survey of theoretical pragmatics in contemporary linguistics. Among the topics that are addressed in the essay include the Anglo-American, and European Continental schools of thought; neo-Gricean pragmatic, and Relevance theories, the pragmatics-semantics interface; and the pragmatics-syntax interface. | HUANG Yan (Department of Linguistic Science, University of Reading, Reading RG6 6AA, England) | 2001 | 外国语2001，24，1： | 33 |
| 3 | Lessons from Rotor 37显示文摘NASA rotor 37 was used as a ’blind’ test case for turbomachinery CFD by the Turbimachinery Com-mittee of the IGTI. The rotor is a transonic compressor with a tip speed of 454 m/s (15OO ft/s) anda relatively high pressure ratio of 2.1. It was tested in isolation with a circumferentially uniform inletflow so that the flow through it should be steady apart from any effects of passage to passage geometry variation and mechanical vibration. As such it represents the simplest possible type of test forthree-dimensional turbomachinery flow solvers. However, the rotor still presents a real challenge to3D viscous flow solvers because the shock wave-boundary layer interaction is strong and the effects ofviscosity are dominant in determining the flow deviation and hence the pressure ratio. Eleven ’blind’solutions were submitted and in addition a ’non-blind’ solution was used to prepare for the exercise-This paper reviews the fiow in the test case and the comparisons of the CFD solutions with the testdata. Lessons for both the Flow Physics in transonic has and for the application of CFD to suchmachines are pointed out. | J.D. Denton(Whittle Laboratory Cambridge University Engineering Dept., Cambridge, England) | 1997 | Journal of Thermal Science1997，6，1： | 29 |
| 4 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 5 | 参与式渭南地震情景构建:中国地震风险对策的行动研究示范显示文摘中国政府层面自上而下的防震减灾管理卓有成效;但是,对于提升全社会的整体防震减灾能力而言,尚需推动基于此而又有民众与基层自下而上广泛参与的全社会治理模式。为发展这种模式积累经验,渭南市地震情景构建示范项目借助参与式行动研究范式,特别关注了中国防震减灾工作当前存在的以下2点广泛不足:一是社会民众与基层的自下而上办法薄弱,且与政府层面自上而下对策之间的相互衔接与促进不足;二是科学研究向实际减灾对策的转化不足,特别是针对自下而上办法的科学研究与应用转化不足。取得的主要进展有:1)基于广泛参与理念,通过'研究者'和'减灾实践者'、'相关者'、'当事人'2方面人员间的密切合作,共同诊断评估了渭南面临的主要地震灾害风险及隐患、共同提炼了针对性的减灾对策改进建议等,从而使情景构建所得的结果或认识更加可靠、所提对策建议更加符合当地实际需要;借助行动研究过程平台,尝试了风险评估、风险沟通和风险对策改进3大环节的无缝衔接与同步互动,促进了科学研究与实际应用的直接对接与就地转化。2)基于多尺度、多层面视角和同时为'政府'或'部门'与'基层'或'民众'两大类用户服务。在关注改进自上而下对策的同时,针对薄弱的自下而上办法,特别是就这两大对策途径间最广泛与最可持续的接口——宣传教育和家庭、学校、社区减灾,开展了大规模的专项调查分析,梳理了系列化的现今本底与改进方向。3)聚焦改善减灾宣教和促进风险沟通,编创了由'故事'引导的2版内容与形式均有显著差别的地震情景叙事读本:政府版和公众版,以期借助'故事'和艺术呈现'故事'带动人们更好地理解与应用情景构建结果和认识,借助'故事'演绎社会性灾害脆弱成分——'留守儿童家庭与贫困'之于灾害的强化与叠加效应,促进人们对地震灾害风险更加全面与深入的认识;在理性刻板科学中融入感性与人文艺术情怀,以引导共识与共鸣、改善减灾态度、培养减灾价值观,进而激发减灾行动和减灾参与意愿,特别是激励人们就相关问题进行长期思考和持续行动改善。以上3方面进展,从总体上实现了对中国防震减灾工作存在的前述2点广泛不足的有益研讨与部分弥补推动尝试。参与式渭南地震情景构建行动研究示范,对国内相关工作具有抛砖引玉的作用,也为国际同类工作积累了中国经验。 | 苏桂武 Janise Rodgers 田青 齐文华 Philip England Timothy Sim John Young 王东明 李志强 冯希杰 孙磊 陈鲲 Emily So Barry Parsons 赵金礼 石建梁 袁志祥 Yue Cao 周旗 魏本勇 David Milledge Alexander Densmore | 2020 | 地震地质2020，42，6： | 6 |
| 6 | A GPA diagnostic system foraeroengine applications显示文摘In this research,a GPA(Gas Path Analysis) diagnostic system enhanced with GPA Index is described for gas path sensor and component fault diagnosis.A method of measurement correction is used in order that the measurement data obtained at un-standard ambient and operating conditions can be used for diagnostic analysis.The developed diagnostic system has been implemented into a Cranfield University gas turbine performance and diagnostic analysis software PYTHIA for gas turbine performance degradation analysis.The developed method and software have been applied to a model aero gas turbine engine to test the effectiveness of the system.The analysis shows that the developed diagnostic system can diagnose degraded sensor and components effectively using performance deviation measured at un-standard ambient and operational conditions.Theoretically,the idea of the diagnostic approach can be applied to different gas turbine engines. | Yi-Guang Li(School of Engineering,Cranfield University,Cranfield,Bedford MK43 0AL,England) | 2007 | 航空动力学报2007，22，6： | 5 |
| 7 | Counting Function Asymptotics and the Weak Weyl-Berry Conjecture for Connected Domains with Fractal Boundaries | Chen Hua (Department of Mathematics,Wuhan University,Wuhan 430072,China)(Email:chenhua@whu,edu.cn)Brian D.Sleeman (School of Mathematics,University of Leeds,Leeds LS2 9JT,England,UK)(Email:bds@amsta.leeds,ac.uk) | 1998 | Acta Mathematica Sinica,English Series1998，14，2： | 3 |
| 8 | Characteristics of echolocating bats’auditory stereocilia length, compared with other mammals显示文摘The stereocilia of the Organ of Corti in 4 different echolocating bats, Myotis adversus, Murina leuco-gaster, Nyctalus plancyi (Nyctalus velutinus), and Rhinolophus ferrumequinum were observed by using scanning electron microscopy (SEM). Stereocilia lengths were estimated for comparison with those of non-echolocating mammals. The specialized lengths of outer hair cells (OHC) stereocilia in echolocating bats were shorter than those of non-echolocating mammals. The specialized lengths of inner hair cells (IHC) stereocilia were longer than those of outer hair cells stereocilia in the Organ of Corti of echolocating bats. These characteristics of the auditory stereocilia length of echolocating bats represent the fine architecture of the electromotility process, helping to adapt to high frequency sound and echolocation. | YAO Qian1,6, ZENG JinYao2, ZHENG YongMei3, Julia LATHAM4, LIANG Bing1, JIANG Lei3 & ZHANG ShuYi51 Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China 2 College of Wildlife Resources, Northeast Forestry University, Harbin 150040, China 3 Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China 4 Zoological Society of London, Institute of Zoology, London, NW1 4RY, England 5 School of Life Science, East China Normal University, Shanghai 200062, China 6 Graduate University of Chinese Academy of Sciences, Beijing 100049, China These authors contributed equally to this work | 2007 | Science China(Life Sciences)2007，50，4： | 2 |
| 9 | Particle Size Distribution,Powder Agglomerates and Their Effects on Sinterability of Ultrafine Alumina Powders显示文摘An intensive study of the particle size distribution of four commercial ultrafine alumina powders to obtain information about the powder agglomeration and relate them to the compactibility and the sinterability has been made. | Renjie ZENG (Dept. of Materials Science, University of Xiamen, Xiamen 361005, China) B.Rand (Dept.of Materials, University of Leeds, Leeds LS2 9JT, England) | 2000 | Journal of Materials Science & Technology2000，16，4： | 2 |
| 10 | A land-surface process/radiobrightness model with coupled heat and moisture transport for fresszing soils显示文摘 | Liou Y A England A W | 1998 | IEEE Transactions on geoscience and remote sensing1998，36，2： | 2 |
| 11 | A crack between dissimilar media显示文摘 | England A H | 1965 | Journal of Applied Mechanics1965，32，3： | 2 |
| 12 | Raman Spectroscopic Studies on the Complexation and Adsorbed Behaviour of Thiourea显示文摘Raman spectroscopic studies on thiourea (TU) in highly acidic media (e. g. >3 mol/L HC1O4) show that TU as a solution species is protonated through its sulphur atom and forms complex with anions. However, as an adsorbed species, TU is protonated via the nitrogen atom and adsorbed at the silver electrode surface through the sulphur atom. The distinct effects of pH and anions of the solution on the surface enhanced Raman (SER) spectra of TU were investigated. In acidic and neutral solutions, TU is coadsorbed with anions through its NH3+ and - NH2 groups respectively. | Tian Zhongqun (Department of Chemistry, Xiamen University, Xiamen)Fleischmann, Martin (Department of Chemistry, Uneversity of Soutbamptoe, England) | 1989 | Chemical Research in Chinese Universities1989，5，3： | 2 |
| 13 | Localized Benign and Malignant Fibrous Tumors of the Pleura: A Clinicopathologic Review of 223 Cases显示文摘 | Douglas M. England Liselotte Hochholzer Michael J. McCarthy | 1989 | The American Journal of Surgical Pathology1989，，8： | 2 |
| 14 | Complications and Outcome After Acute Stroke: Does Dysphagia Matter?显示文摘 | D.G. Smithard NA O’Neill C. Park J. Morris R. Wyatt R. England D.F. Martin | 1996 | Stroke A Journal of Cerebral Circulation1996，，7： | 2 |
| 15 | A crack between dissimilar media显示文摘 | England A H | 1955 | Journal of Applied Mechanics1955，32，3： | 1 |
| 16 | An exponential model used for optimal threshold selection on ROC curves显示文摘 | | 1988 | Medical Decision Making1988，，： | 1 |
| 17 | The organic geochemistry of petroleum reservoirs显示文摘 | | 1990 | Organic Geochemistry1990，16，13： | 1 |
| 18 | The role of the Indone- sian Throughflow on ENSO dynamics in a coupled 'climate model 显示文摘 | Santoso A Cai W England M H | 2011 | Journal of Climate2011，24，： | 1 |
| 19 | The movement entrapment of petroleum fluid in the subsurface显示文摘 | England D A | 1987 | Journal of Geological Society London1987，114，： | 1 |
| 20 | Radiobrightness of Diurnal Heated Freezing Soil显示文摘 | England A W | 1990 | IEEE Trans GRS1990，28，： | 1 |
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