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| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Artificial intelligence in gastroenterology: A state-of-the-art review显示文摘The development of artificial intelligence(AI)has increased dramatically in the last 20 years,with clinical applications progressively being explored for most of the medical specialties.The field of gastroenterology and hepatology,substantially reliant on vast amounts of imaging studies,is not an exception.The clinical applications of AI systems in this field include the identification of premalignant or malignant lesions(e.g.,identification of dysplasia or esophageal adenocarcinoma in Barrett’s esophagus,pancreatic malignancies),detection of lesions(e.g.,polyp identification and classification,small-bowel bleeding lesion on capsule endoscopy,pancreatic cystic lesions),development of objective scoring systems for risk stratification,predicting disease prognosis or treatment response[e.g.,determining survival in patients post-resection of hepatocellular carcinoma),determining which patients with inflammatory bowel disease(IBD)will benefit from biologic therapy],or evaluation of metrics such as bowel preparation score or quality of endoscopic examination.The objective of this comprehensive review is to analyze the available AI-related studies pertaining to the entirety of the gastrointestinal tract,including the upper,middle and lower tracts;IBD;the hepatobiliary system;and the pancreas,discussing the findings and clinical applications,as well as outlining the current limitations and future directions in this field. | Paul T Kröner Megan ML Engels Benjamin S Glicksberg Kipp W Johnson Obaie Mzaik Jeanin E van Hooft Michael B Wallace Hashem B El-Serag Chayakrit Krittanawong | 2021 | World Journal of Gastroenterology2021，27，40： | 6 |
| 3 | Search for a dark photon in the π 0 → e + e ? γ decay显示文摘 | P. Adlarson W. Augustyniak W. Bardan M. Bashkanov F.S. Bergmann M. Ber?owski H. Bhatt A. Bondar M. Büscher H. Calén I. Ciepa? H. Clement D. Coderre E. Czerwiński K. Demmich E. Doroshkevich R. Engels W. Erven W. Eyrich P. Fedorets K. F?hl K. Fransson F. Go | 2013 | Physics Letters B . 2013 (1-3)2013，，1： | 3 |
| 4 | Composition and biological activity of different extracts from Schisandra sphenan- thera and Schisandra chinensis显示文摘 | Huyke C Engel K Simon-Haarhaus B | 2007 | Planta Med2007，73，10： | 1 |
| 5 | Structural determinants of water permeation through aquaporin-1 显示文摘 | MIYAMOTO K MITSUOKA K HIRAI T WALZ T AGRE P HEYMANN J B ENGEL A FUJIYOSHI Y | 2000 | Nature2000，407，： | 1 |
| 6 | Effects of trehalose and sucrose, osmolality of the freezing medium,and cooling rate on viability and intactness of bull sperm after freezing and thawing 显示文摘 | Woelders H Matthijs A Engel B | 1997 | Cryobiology1997，35，： | 1 |
| 7 | Forecasting land use change and its environmental impact at a watershed scale显示文摘 | Tang Z Engel B A Pijanowski B C | 2005 | Journal of Environmental Management2005，76，： | 1 |
| 8 | Initiators for endothermic fuels 显示文摘 | Wickham D T Engel J R Hitch B D etal | 2001 | J Propul Power2001，17，： | 1 |
| 9 | Chilling pig carcasses:effects on temperature,weight loss and ultimate meat quality显示文摘 | VANDERWAL P G ENGEL B BEEK G V | 1995 | Meat Science1995，40，： | 1 |
| 10 | Xenobiotic phenols in early pregnancy amniotic fluid 显示文摘 | Engel S M Levy B Liu Z | 2006 | Reproductive Toxicology2006，21，1： | 1 |
| 11 | Inhibition of Growth of Experimental Human Endometrial Cancer by an Antagonist of Growth Hormone-Releasing Hormone显示文摘 | Engel Jorg B Keller Gunhild Schally Andrew V | 2005 | Joumal of Clinical Endocrinology&Metabolism2005，90，6： | 1 |
| 12 | Nonpoint source (NPS) pollutant modeling using models integrated with geographic information systems (GIS)显示文摘 | Engel B A Srinivasan R Arnold J | 1993 | Water Science and Technology1993，28，35： | 1 |
| 13 | Cell density of human lens epithelium in women higher than in men 显示文摘 | Guggenmoos-Hoizmann I Engel B Henke V | 1989 | Invest Ophthalmol Vis Sci1989，30，： | 1 |
| 14 | Chondroblastoma of the patella with pathological fracture显示文摘 | Rischke B Engels C Pietsch E | 2000 | Unfallchirurgie2000，103，10： | 1 |
| 15 | A spatial decision on support system for assessing agricultural non-point source pollution显示文摘 | SRINIVASAN R ENGEL B A | 1994 | Water Re- sources Bulletin1994，30，3： | 1 |
| 16 | Assessing water- shed-scale, long-term hydrologic impacts of land use change using a GIS-NPS model显示文摘 | Bhaduri B Harbor J Engel B A | 2000 | Environmental Man- agement2000，26，6： | 1 |
| 17 | Detection of extracellular factor-positive Streptococcus suis serotype 2 strains in tonsillar swabs of live sows by PCR显示文摘 | Wisselink H J Engel B | 2005 | Vet Microbiol2005，109，34： | 1 |
| 18 | Light and electron microscopic localization of beta-amyloid protein in muscle biopsies of patients with inclusion-body myositis显示文摘 | ASKANAS V ENGEL W K ALVAREZ R B | 1992 | Am J Pathol1992，141，1： | 1 |
| 19 | Assessing watershed-scale,long-term hydrologic impacts of land use change using a GIS-NPS model显示文摘 | Bhaduri B Harbor J Engel B A | 2000 | Environmental Management2000，26，6： | 1 |
| 20 | Management of Data Streams for a Real Time Flood Simulation显示文摘 | GADGIL H CHOI J Y ENGEL B | 2004 | Community Grids Lab Technical Report2004，44，32： | 1 |
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