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| 1 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 2 | E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology assocated with age-dependent,detrimental motor impairment显示文摘 | EMMER K L WAXMAN E A COVY J P | | 0，，40： | 1 |
| 3 | Nitrogen isotope variations in Santa Barbara Basin sediments: Implications for denitrification in the eastern tropical North Pacific during the last 50,000 years显示文摘 | EMMER E THUNELL R C | 2000 | Paleoceanography2000，15，： | 1 |
| 4 | Peripheral natural killer cytotoxicity and CD56^posCD16^pos cells increase during early Pregnancy in women with a history of recurrent spontaneous abortion 显示文摘 | EMMER P M NELEN WLDM STEEGER E A P | 2000 | Hum Reprod2000，15，5： | 1 |
| 5 | Regulation of the rabbit ileal brush-border Na^+/H^+ exchanger by an ATP-requiring Ca^2+/calmodulin-mediated process 显示文摘 | Rood R P Emmer E Wesolek J | 1988 | The Journal of Clinical Investigation1988，82，： | 1 |
| 6 | Altered phenotype of HLA-G expressing trophoblast and decidual natural killer cells in pathological pregnancies 显示文摘 | Emmer P M Steegers E A P Kerstens H M J | 2002 | Hum Repro2002，17，4： | 1 |
| 7 | Effects of gabapentin on cognition and quality of life in patients with epilepsy显示文摘 | Mortimore C Trimble M Emmers E | 1998 | Seizure1998，7，5： | 1 |
| 8 | Altered phenotype of HLA-C expressing trophoblast and ducidual natural killer cells in pathological pregnancies 显示文摘 | Emmer P M Steegers E A Kerstens H M | 2002 | Hum Reprod2002，17，4： | 1 |
| 9 | Altered phenotype of HLA-G expressing trophoblast and decidual natural killer cells in pathological pregnancies 显示文摘 | Emmer P M Steegers E A P Kers rens H M J | 2002 | Hum Reprod2002，17，4： | 1 |
| 10 | Effective classroom management at the beginning of the school year 显示文摘 | EMMER E EVERTSON C ANDERSON L | 1980 | Elem Sch J1980，80，5： | 1 |
| 11 | Amniotic fluid soluble human leukocyte antigen G is markedly decreased in offspring with neural tube defects显示文摘 | Emmer P Steegers E Lierop M | 2002 | Early Hum Dev2002，66，2： | 1 |
| 12 | Peripheral natural killer cytotoxicity and CD56(POs)CD16 (pos) cells increase during early pregnancy in women with a history of recurrent sponta- neous abortion显示文摘 | EMMER P M NELEN W L STEEGERS E A | 2000 | Hum Reprod2000，15，5： | 1 |
| 13 | Characterization of carp thrombocytes with specific monoclonal antibodies显示文摘 | Koumans-Van D J C E Emmer P M | 1996 | J Fish Biol1996，49，： | 1 |
| 14 | Effects of gabapentin on cognition and quality of life in patients with epilepsy显示文摘 | Mortimore C Trimble M Emmers E | 1998 | Seizure1998，7，4： | 1 |
| 15 | Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the MR CLEAN Registry显示文摘Background Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen well.However,outcomes after EVT in these late window patients without perfusion imaging are largely unknown.We assessed their characteristics and outcomes in routine clinical practice.Methods The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and 2017.CT perfusion was no standard imaging modality.We used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified Rankin Scale(mRS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous thrombolysis.Outcomes included 3-month mRS score,functional independence(defined as mRS 0-2),and death.Results Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQR 6.9-10.6),of whom 93(87.7%)had unknown time of stroke onset.CT perfusion was not performed in 87/106(80.2%)late window patients.Late window patients were younger(mean 67 vs 70 years,p<0.04)and had slightly lower ASPECTS(median 8 vs 9,p<0.01),but better collateral status(collateral score 2-3:68.3%vs 57.7%,p=0.03).No differences were observed in proportions of functional independence(43.3%vs 40.5%,p=0.57)or death(24.0%vs 28.9%,p=0.28).After matching,outcomes remained similar(adjusted common OR for 1 point improvement in mRS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/CT angiography characteristics.randomised controlled trials with lenient inclusion criteria are needed to identify more patients who can benefit from EVT in the late window. | Luuk Dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart J Emmer Ivo G H Jansen Maxim J H L Mulder Robin Lemmens Robert-Jan B Goldhoorn Marieke J H Wermer Jelis Boiten Geert J LycklamaàNijeholt Yvo B W E M Roos Adriaan C G M van Es Hester F Lingsma Diederik W J Dippel Wim H van Zwam Robert J van Oostenbrugge Ido R van den Wijngaard on behalf of the MR CLEAN Registry investigators | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
| 16 | Cooperative learning in elementary classrooms:Teaching Practices and lesson characteristics显示文摘 | EMMER E T GERWELS M C | 2002 | The Elementary School Journal2002，103，1： | 1 |
| 17 | Effects of gabapentin on cognition and quality of life in patients with epilepsy 显示文摘 | Trimble M Emmers E | 1998 | Seizure1998，7，5： | 1 |
| 18 | A scale for measuring teacher efficacy in class- room management and discipline显示文摘 | Emmer E | 1991 | Educational and Psychological Measurement1991，51，3： | 1 |
| 19 | Pathogenesis of upper airway occlusion during sleep显示文摘 | Emmers J E de Groot W J Sauerland E K | 1978 | J Appl Physiol1978，44，6： | 1 |
| 20 | Cooperative Learning in Ele- mentary Classrooms: Teaching Practices and Lesson Char- acteristics显示文摘 | Emmer E T Gerwels M C | 2002 | The Elementary School Journal2002，103，1： | 1 |
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