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	题名	作者	年代	出处	被引量
1	Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls.	Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong	2017	World Journal of Gastroenterology2017，23，6：	2
2	Altered phenotype of HLA - G expressing trophoblast and decidual natural killer cells in pathological pregnancies 显示文摘	Emmer PM Steegers EAP Kerstens H	2002	Hum Reprod2002，17，4：	1
3	Optimal portfolios with bounded capital at risk显示文摘	EMMER S KLPPELBERG C KORN R	2001	Mathematical Finance2001，11，4：	1
4	Oil-filled polymer microcapsules for ultrasound-mediated delivery of lipophilic drugs显示文摘	Kooiman KB hmer MR Emmer M		0，，02：	1
5	Preoperative 显示文摘	Emmering J Krak NC Van der Hoeven JJ	2008	Ann Oncnl2008，19，9：	1
6	Effect of composition on friction coefficient of Cu- graphite composites 显示文摘	Kovacik J Emmer S Bielek J	2008	Wear2008，265，34：	1
7	Altered phenotype of HLA-G expressing trophoblast and decidual natural killer cells in pathological pregnancies显示文摘	Emmer PM Steegers EA Kerstens HM	2002	Hum Re prod2002，174，：	1
8	Calculating Credit Risk Cap- ital Charges with the One - Factor Model 显示文摘	Emmer Susanne Tasche Drik	2004	Journal of Risk2004，，7：	1
9	Oil-filled polymer microcapsules for ultrasound-mediated delivery of lipophilic drugs 显示文摘	Kooimana K Bohmerb M Emmer M	2009	J of Control Release2009，133，2：	1
10	Tract-based spa tim statistics on diffusion tensor imaging in systemic lupus ery thematosus reveals localized involvement of white matter tracts 显示文摘	Emmer BJ Veer IM Steup-Beekman GM	2010	Arthritis Rheum2010，62，37：	1
11	Effect of composition on friction coefficient of Cu-graphite composites 显示文摘	KOVACIK J EMMER S BIELEK J	2008	Wear2008，265，34：	1
12	E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology assocated with age-dependent,detrimental motor impairment显示文摘	EMMER K L WAXMAN E A COVY J P		0，，40：	1
13	Amniotic fluid soluble human leukocyte antigen G is markedly decreased in offspring with neural tube defects显示文摘	Emmer P	2002	Early Hum Dev2002，66，2：	1
14	Altered phenotype of HLA - G expressing tropho- blast and decidual natural killer ceils in pathological pregnancies 显示文摘	Emmer PM	2002	Hum 'Reprod2002，17，4：	1
15	Characterization ofproteinases from Antarctic krill(Euphausia superba)显示文摘	Sjodahl J Emmer A Vincent J	2002	ProteinExpression and Purification2002，26，1：	1
16	Effect of composition on friction coefficient of Cu-graphite composites显示文摘	Kovacik J Emmer S Bielek J	2008	Wear2008，265，34：	1
17	Nitrogen isotope variations in Santa Barbara Basin sediments: Implications for denitrification in the eastern tropical North Pacific during the last 50,000 years显示文摘	EMMER E THUNELL R C	2000	Paleoceanography2000，15，：	1
18	A new approach to dynamic deactivation in capillary zone electrophoresis 显示文摘	Emmer A Jansson M Roemade J	1991	J Chromatogr1991，，：	1
19	Temperature-dependent nitrogen transformations in acid oak-beech forest litter in the Netherlands 显示文摘	Emmer M Tietema A	1990	Plant and Soil1990，122，：	1
20	Allogeneic stimulation of naturally occurring CD4^+ CD25^+ T cells induces strong regulatory capacity with increased donor-reactivity显示文摘	Coenen J Koenen H Emmer P	2007	Transplant Immunology2007，17，4：	1

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