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您的检索式：作者名="Susan Yost"
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| 1 | Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses显示文摘Oral squamous cell carcinoma(OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community composition and OSCC has been thoroughly investigated, microbial profiles of the human microbiome in cancer are understudied. Here we performed a small pilot study of community-wide metatranscriptome analysis to profile mRNA expression in the entire oral microbiome in OSCC to reveal molecular functions associated with this disease. Fusobacteria showed a statistically significantly higher number of transcripts at tumour sites and tumour-adjacent sites of cancer patients compared to the healthy controls analysed. Regardless of the community composition, specific metabolic signatures were consistently found in disease. Activities such as iron ion transport, tryptophanase activity, peptidase activities and superoxide dismutase were over-represented in tumour and tumour-adjacent samples when compared to the healthy controls. The expression of putative virulence factors in the oral communities associated with OSCC showed that activities related to capsule biosynthesis, flagellum synthesis and assembly, chemotaxis, iron transport, haemolysins and adhesins were upregulated at tumour sites. Moreover, activities associated with protection against reactive nitrogen intermediates, chemotaxis, flagellar and capsule biosynthesis were also upregulated in non-tumour sites of cancer patients. Although they are preliminary, our results further suggest that Fusobacteria may be the leading phylogenetic group responsible for the increase in expression of virulence factors in the oral microbiome of OSCC patients. | Susan Yost Philip Stashenko Yoonhee Choi Maria Kukuruzinska Caroline A.Genco Andrew Salama Ellen O.Weinberg Carolyn D.Kramer Jorge Frias-Lopez | 2018 | International Journal of Oral Science2018，10，4： | 9 |
| 2 | Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patients显示文摘 | Claus U. Niemann C.Spencer Yost Susan Mandell Thomas K. Henthorn | 2002 | Liver Transplantation2002，，5： | 1 |
| 3 | Validation of the Functional Assessment of Cancer Therapy-Breast Symptom Index (FBSI)显示文摘 | Kathleen J. Yost Susan E. Yount David T. Eton Cheryl Silberman Anne Broughton-Heyes David Cella | 2005 | Breast Cancer Research and Treatment2005，，3： | 1 |
| 4 | x86架构丰富联网汽车中的交互体验显示文摘引言随着Web服务、内容和应用的日益普及,包括汽车制造商以及服务和内容提供商在内的众多厂商都迎来了巨大的商机。汽车制造商可以借此提供开放的信息娱乐平台,使之以多种方式连接到互联网,并在平台硬件的支持下高效、灵活而安全地运行最新、最完善的Web应用。 | Brad Starks Susan Yost | 2008 | 世界电子元器件2008，，7： | 0 |
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