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| 1 | The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy显示文摘Tumor cells have an increased demand for glucose and amino acids to support their rapid growth,and also exhibit alterations in biochemical pathways that metabolize these nutrients.Transport across the plasma membrane is essential to feed glucose and amino acids into these tumor cell-selective metabolic pathways.Transfer of amino acids across biological membranes occurs via a multitude of transporters;tumor cells must upregulate one or more of these transporters to satisfy their increased demand for amino acids.Among the amino acid transporters,SLC6A14 stands out with specific functional features uniquely suited for the biological needs of the tumor cells.This transporter is indeed upregulated in tumors of epithelial origin,including colon cancer,cervical cancer,breast cancer,and pancreatic cancer.Since normal cells express this transporter only at low levels,blockade of this transporter should lead to amino acid starvation selectively in tumor cells,thus having little effect on normal cells.This offers a novel,yet logical,strategy for the treatment of cancers that are associated with upregulation of SLC6A14.In addition,a variety of amino acid-based prodrugs are recognized as substrates by SLC6A14,thus raising the possibility that anticancer drugs can be delivered into tumor cells selectively via this transporter in the form of amino acid prodrugs.This strategy allows exposure of SLC6A14-positive tumor cells to chemotherapy with minimal off-target effects.In conclusion,the amino acid transporter SLC6A14 holds great potential not only as a direct drug target for cancer therapy but also for tumor cell-selective delivery of anticancer drugs. | Yangzom D.Bhutia Ellappan Babu Puttur D.Prasad Vadivel Ganapathy | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，6： | 8 |
| 2 | Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer显示文摘Based on the evidence that hemochromatosis, an iron-overload disease, drives hepatocellular carcinoma, we hypothesized that chronic exposure to excess iron, either due to genetic or environmental causes, predisposes an individual to cancer. Using pancreatic cancer as our primary focus, we employed cell culture studies to interrogate the connection between excess iron and cancer, and combined in vitro and in vivo studies to explore the connection further. Ferric ammonium citrate was used as an exogenous iron source. Chronic exposure to excess iron induced epithelial-mesenchymal transition(EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes(p21, cyclin D1, Bax, SLC7A11). To further extrapolate our cell culture data, we generated EL-KrasG12D( EL-Kras) mouse(pancreatic neoplastic mouse model) expressing Hfe+/+ and Hfe-/- genetic background. p53 target gene expression decreased in EL-Kras/Hfe-/- mouse pancreas compared to EL-Kras/Hfe+/+ mouse pancreas. Interestingly, the incidence of acinar-to-ductal metaplasia and cystic pancreatic neoplasms(CPN) decreased in EL-Kras/Hfe-/- mice, but the CPNs that did develop were larger in these mice than in EL-Kras/Hfe+/+ mice. In conclusion, these in vitro and in vivo studies support a potential role for chronic exposure to excess iron as a promoter of more aggressive disease via p53 loss and SLC7A11 upregulation within pancreatic epithelial cells. | Yangzom D.Bhutia Jiro Ogura Paul J.Grippo Carolina Torres Toshihiro Sato Mitchell Wachtel Sabarish Ramachandran Ellappan Babu Sathish Sivaprakasam Devaraja Rajasekaran Bradley Schniers Nhu On Logan Smoot Muthusamy Thangaraju Jaya P.Gnana-Prakasam Vadivel Ganapathy | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 1 |
| 3 | α-Glucosidase and α-Amylase Inhibitory Activity of Senna surattensis显示文摘 | Ellappan Thilagam Balasubramaian Parimaladevi Chidambaram Kumarappan Subhash Chandra Mandal | 2012 | Journal of Acupuncture and Meridian Studies2012，，： | 1 |
| 4 | Antioxidant Activity of Senna surattensis Leaves显示文摘 | Ellappan Thilagam Chidambaram Kumarappan Balasubramanian Parimaladevi | 2012 | International Journal of advance in pharmacy biology and chemistry2012，1，4： | 1 |
| 5 | Interaction of human organic anion transporters with various cephalosporin antibiotics显示文摘 | Michio Takeda Ellappan Babu Shinichi Narikawa Hitoshi Endou | 2002 | European Journal of Pharmacology2002，，3： | 1 |
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