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| 1 | Effect of Biophytum sensitivum on streptozotocin and nicotinamideinduced diabetic rats显示文摘Objective:To investigate the effect of aqueous solution of Biophytum sensUiuum leaf extract(BSEt)on normal and strcptozotocin(STZ)-nicotinamide-induced diabetic rats.Methods:Diabetes was induced in adult male Wislar rata by the administration of STZ-nicotinamide(40,110 mg/kg b.w.,respectively)intraperitoneally.BSEt(200 mg/kg)was administered to diabetic rats for 28 days.The effect of extract on blood glucose,plasma insulin,total haemoglobin,glycosylated haemoglobin,liver glycogen and carbohydrate melatxilism regulating enzymes of liver was studied in diabetic rats.Results:BSEt significantly reduced the blood glucose and glycosylated haemoglobin levels and significantly increased the total haemoglobin,plasma insulin and liver glycogen levels in diabetic rats.It also increased the hexokinase activity and decreased glucose-6-phosphatase,fructose-1,6-bisphosphatase activities in diabetic rats.Conclusions:The results of our study suggest that BSEt possesses a promising effecl on STZ-nicotinamide-induced diabetes. | Ananda Prabu K Kumarappan CT Sunil Christudas Kalaichelvan VK | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，1： | 5 |
| 2 | Antibacterial potential of sponge endosymbiont marine Enterobacter sp at Kavaratti Island,Lakshadweep archipelago显示文摘Objective:To isolate antibacterial potential of sponge endosymbiotic bacteria from marine sponges at Lakshadweep archipelago.Also to identify the potent bacteria by 16s rDNA sequencing and determine the antibacterial activity against clinical pathogens by MIC.Methods: Sponge samples was collected from sub-tidal habitats at Kavaratti Island and identified.The endosymbiotic bacteria were isolated and selected potential bacteria which show antibacterial activity in preliminary screening against clinical pathogens Staphylococcus aureus(S.aureus), Escherichia coli(E.coli),Salmonella typhi(S.typhi),Klebsiella pneumoniea(K.pneumoniea) and Streptococcus sp.by disc diffusion assay.The crude extracts of potential bacteria LB3 was tested against clinical pathogens by MIC.The LB3 strain was identified by 16s rDNA sequencing, 1111 bp was submitted in NCBI(HQ589912) and constructed phylogenetic tree.Results:Sponge sample was identified as Dysidea granulosa(D.granulosa) and potential bacteria LB3 identified as Enterobacter sp TTAG.Preliminary screening of sponge isolates against clinical pathogens,LB3 strain was selected as potential producer of secondary metabolites and crude extract was implies on MIC of LB3 have confirmed with lowest concentration of 5.0 mg/mL in broth medium influence of crude extract on growth inhibitory activity after 5 h of incubation period and completed the inhibitory activity at 15 h.Conclusions:The present study concluded that phylogenetic analysis of endosymbiotic bacteria Enterobacter sp from sponge D.granulosa of Lakshadweep islands showed significant antibacterial activity against clinical bacterial pathogens. | Mohan Gopi Subramanian Kumaran Thipparamalai Thangappanpillai Ajith Kumar Balaraman Deivasigamani Kumarappan Alagappan Srinivasan Guru Prasad | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 2 |
| 3 | Antibiotic resistant Esherichia coli strains from seafood and its susceptibility to seaweed extracts显示文摘Objective:To determine the prevalence and antibiotic resistance of Escherichia coli(E. coli),in seafood obtained from Cuddalore and Parangipettai fish landing centres.Also,to identify the susceptibility of E.coli against predominant seaweeds red alga Kappaphycus alvarezii(K.alvarezii) and brown alga Padina boergessenii(P.boergessenii) extracts as sulfated polysaccharides and polyphenols respectively.Methods:A total of 48 samples(Two stations Cuddalore and Parangipettai,Tamil Nadu,India).Sampling area are fish landing centre where fishes caught from sea and estuary,seafood processing plants(packing and ice packed fishes) and local fish markets(fish samples).After isolation totally 80 strains were analyzed for its antimicrobial resistance and sensitivity against commercially 10 antibiotics.The ampicillin resistant E.coli CE21 was identified through molecular techniques as I6S rDNA sequencing. Two seaweeds K.alvarezii and P.boergessenii were screened lor antibacterial activity against 12 antibiotic resistant E.coli strains.Results:Totally 48 swabbed samples from two different fish handling area were characterized for total bacterial and E.coli count.Mostly,the E.coli strains were isolated from fish local market and seafood processing plants before and after packaging process.In that maximum 56.25%strains were resistant to ampicillin and the minimum 2.5%strains were resistant to chloramphenicol.Therefore,the E.coli CE21 was identified through molecular techniques E.coli(GenBank accession number GU065251),The MIC value for polyphenol extract was slightly less than sulfated polysaccharides.E.coli strain isolated from Parangipettai was considerably increased MIC value that Cuddalore.Conclusions: The polyphenol and sulfated polysaccharides showed promising inhibitory response against all antimicrobial resistant E.coli strains and in particular the inhibitory response of ampicillin resistant E.coli. | Subramanian Kumaran Balaraman Deivasiganiani Kumarappan Alagappan Mannikam Sakthivel Rajamani Karthikeyan | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 1 |
| 4 | α-Glucosidase and a-amylase inhibitory activity of Senna surattensis显示文摘 | THILAGAM E PARIMALADEVI B KUMARAPPAN C | 2013 | Journal of Acupuncture and Meridian Studies2013，6，1： | 1 |
| 5 | a-Glueosidase inhibitory activity and in vitro antioxidant activities of alcohol-water extract (AWE)of Ichnocarpus frutescens leaves显示文摘 | Kumarappan C Mandal SC | 2008 | Med Chem Res2008，17，： | 1 |
| 6 | a-Glucosidase and a-amylase inhibitory activity of Senna surattensis显示文摘 | THILAGAM E PARIMALADEVI B KUMARAPPAN C | 2013 | Journal of Acupuncture and Meridian Studies2013，6，1： | 1 |
| 7 | α-Glucosidase and α-Amylase Inhibitory Activity of Senna surattensis显示文摘 | Ellappan Thilagam Balasubramaian Parimaladevi Chidambaram Kumarappan Subhash Chandra Mandal | 2012 | Journal of Acupuncture and Meridian Studies2012，，： | 1 |
| 8 | Antioxidant Activity of Senna surattensis Leaves显示文摘 | Ellappan Thilagam Chidambaram Kumarappan Balasubramanian Parimaladevi | 2012 | International Journal of advance in pharmacy biology and chemistry2012，1，4： | 1 |
| 9 | α-Glucosidase inhibitory activity and in vitro antioxidant activities of alcohol-water extract (AWE) of Ichnocarpus frutescens leaves 显示文摘 | Kumarappan C Mandal S C | 2008 | Med Chem Res2008，17，： | 1 |
| 10 | Hybrid improved binary particle swarm optimization approach for generation maintenance scheduling prob- lem 显示文摘 | Suresh K Kumarappan N | 2013 | Swarm and Evolutionary Computation2013，4，9： | 1 |
| 11 | Trading greenhouse gas emission benefits from biofuel use in US transportation: Challenges and opportunities 显示文摘 | Subbu Kumarappan Satish Joshi | 2011 | Biomass and Bioenergy2011，35，11： | 1 |
| 12 | Measurement of the average size and density of clusters in a gas jet显示文摘 | Kim K Y Kumarappan V Milchberg H M | 2003 | Appl Phys Lett2003，83，： | 1 |
| 13 | Measurement of the average size and density of dusters in a gas jet显示文摘 | Kim K Y Kumarappan V Milchberg H M | 2003 | Appl Phys Lett2003，83，： | 1 |
| 14 | Antitumor activity of polyphe-nolic extract of Ichnocarpus frutescens显示文摘 | Mandal SC | 2007 | Exp Oneol2007，29，2： | 1 |
| 15 | Antioxidant activity of polyphenolic extracts of Ichnocarpus frutescens显示文摘 | Kumarappan C T Thilagam E Mandal S C | 2012 | Saudi Journal of Biological Sciences2012，，19： | 1 |
| 16 | Fuel restricted short term economic dispatch using evolutionary programming for utility system显示文摘 | Kumarappan N Mohan M R | 2003 | Electrical Power and Energy Systems2003，25，10： | 1 |
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