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		题名	作者	年代	出处	被引量
	1	Targeted expression of human FSH receptor Asp567Gly mutant mRNA in testis of transgenic mice: role of humanFSH receptor promoter显示文摘Aim:To specifically express the Asp567Gly human follicle-stimulating hormone receptor (FSHR) under the control of its promoter to evaluate the phenotypic consequences in the presence of normal pituitary function.Methods:We produced transgenic mice overexpressing the Asp567Gly human FSHR under the control of a 1.5kb 5’-flanking region fragment of its promoter.Results: Mice were phenotypically normal and fertile.In males,mRNA could be detected in the testis and the brain, indicating that the 1.5kb promoter fragment drives expression not only in the gonads. The testis weight/body weight ratio and the testosterone levels in transgenic and non-transgenic littermates were similar. By in situ hybridisation we found that the transgenic FSHR was highly expressed in Sertoli cells,spermatocytes and round spermatids. However, a radioligand receptor assay failed to show a significant difference in total FSHR binding sites in testis homogenates of transgenic and wild type animals, suggesting that the transgenic FSHR is probably not translated into functional receptor protein. Conclusion: A 1.5kb 5'-region of the human FSHR drives mRNA expression of the transgene in the testis but leads to ectopic expression in germ cells and in the brain. No phenotypic consequences could be documented due to the lack of protein expression.	Verena Nordhoff Jrg Gromoll Luca Foppiani C.Marc Luetjens Stefan Schlatt Elena Kostova Ilpo Huhtaniemi Eberhard Nieschlag Manuela Simoni	2003	Asian Journal of Andrology2003，5，4：	1
	2	Cochlear implants and drug delivery: In vitro evaluation of dexamethasone release显示文摘	Laura Astolfi Valeria Guaran Nicola Marchetti Elena Olivetto Edi Simoni Alberto Cavazzini Claude Jolly Alessandro Martini	2014	J. Biomed. Mater. Res2014，，2：	1
	3	Inhibition of acetylcholinesterase, 13-amyloid aggregation, and NMDA receptors in alzheimer's disease: a promising directionfor the multi-target-directed ligands gold rush显示文摘	Miehela Rosini Elena Simoni Manuela Bartolini Andrea Cavalli Luisa Ceecarini	2008	J Med Chem2008，51，：	1

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