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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 3 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 4 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 5 | Effects of combination lipid therapy in type 2 diabetes mellitus显示文摘 | Ginsberg HN Elam MB Lovato LC | | New England Journal of Medicine0，，： | 4 |
| 6 | Continuous auditing: Building automated auditing capability 显示文摘 | Zabihollah Rezaee Ahmad Sharbatoghlie Rick Elam and Peter L McMickle | 2002 | Auditing2002，，3： | 1 |
| 7 | Subgenomic RNA7 is transcribed with different leader-body junction sites in PRRSV (strain VR2332) infection of CL2621 cells显示文摘 | Faaberg K S Elam M R Nelsen C J | 1998 | Adv Exp Med Biol1998，440，： | 1 |
| 8 | ZnO nanotube based dye-sensitized solar cells 显示文摘 | MARTINSON A B ELAM J W HUPP J T | 2007 | Nano Lett2007，7，8： | 1 |
| 9 | Population genetic consequences of small population size: implications for plant conservation 显示文摘 | Ellstrand NC Elam DR | 1993 | Annual Re- view of Ecology and Systematics1993，34，： | 1 |
| 10 | Mechanical and swelling properties of thermoplastic elastomer blends显示文摘 | M. Abu-Abdeen I. Elamer | 2009 | Materials and Design2009，，2： | 1 |
| 11 | Morphological changes in adult males from resistance exercise and amino acid supplementa- tion 显示文摘 | ELAM R P | 1988 | Journal of Sports Medicine and Physical Fit- ness1988，28，1： | 1 |
| 12 | Aerogel templated ZnO dye-senitized solar cells 显示文摘 | HAMANN T W MARTINSON A B F ELAM J W | 2008 | Adv Mater2008，20，8： | 1 |
| 13 | Surface loss in ozone-based atomic layer depositionprocesses 显示文摘 | KNOOPS H C M ELAM J W LIBERA J A | 2011 | Chemistry of Materials2011，23，23： | 1 |
| 14 | Invasive si-nonasal disease due to dematiaceous fungi in immuno-compromised individuals : case report and review ofthe literature显示文摘 | DERBER C ELAM K BEARMAN G | 2010 | Int J Infect Dis2010，143，： | 1 |
| 15 | Comparison of the structural protein coding sequences of the VR-2332 and Lelystad virus strains of the PRRS virus显示文摘 | Murtaugh M P Elam M R Kakach L | 1995 | Archives of Virology1995，140，： | 1 |
| 16 | A comparison of the mouth-tomouth and mouth-to-airway methods of artificial respiration with the chest-pressure arm-lift methods显示文摘 | Safar P Escarraga LA Elam JO | | 0，，： | 1 |
| 17 | Comparison of the structural protein coding sequences of the VR-2332 and Lelystad virus strains of the PRRS virus显示文摘 | M. P. Murtaugh M. R. Elam L. T. Kakach | 1995 | Archives of Virology1995，，8： | 1 |
| 18 | Comparing millennial and generation X medical students at one medical school显示文摘 | Borges NJ Manuel RS Elam CL | 2006 | Acad Med2006，81，6： | 1 |
| 19 | Population genetic consequences of population size:implications for plant conservation显示文摘 | Ellstrand N C Elam D R | 1993 | Annual Review of Ecology and Systematic1993，24，： | 1 |
| 20 | A comparison of the mouth- to- mouth and mouth- to - airway methods of artificial respiration with the chest - pressure arm - lift methods 显示文摘 | Safar P Escarrage LA Elam JO | 1958 | N Engl J reed1958，258，14： | 1 |
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