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| 1 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 2 | Further delineation of the continuous human neoplastic enterochromaffin cell line,KRJ-I,and the inhibitory effects of lanreotide and rapamycin 显示文摘 | Kidd M Eick GN Modlin IM | 2007 | J Mol Endocrinol2007，38，： | 1 |
| 3 | Kinetics of lead absorption/desorption on goethite residence time effect显示文摘 | EiCk M J Peak J D Brady P V | 1999 | Soil Science1999，164，： | 1 |
| 4 | Lack of cathelicidin processing in Papillon-Lefevre syndrome patients reveals essential role of LL-37 in periodontal homeostasis显示文摘 | Eick S Puklo M Adamowicz K Kantyka T | 2014 | Orphanet J Rare Dis2014，9，： | 1 |
| 5 | Alcohol-induced electrical remodeling: effects of sustained short-term ethanol infusion on ion currents in rabbit atrium 显示文摘 | Laszlo R Eick C Schwiebert M | 2009 | Alcohol Clin Exp Res2009，33，10： | 1 |
| 6 | Hyaluronic Acid as an adjunct after scaling and mot planing: a prospective randomized clinical trial显示文摘 | Eick s Renatus A Heinicke M | 2013 | J Periodontol2013，84，7： | 1 |
| 7 | Adsorption of arsenate (V) and arsenite (III) on goethite in the presence and absence of dissolved organic carbon显示文摘 | GRAFE M EICK M J GROSS P R | 2001 | Soil Science Society of America Journal2001，65，6： | 1 |
| 8 | Arsenate and chromate retention mechanisms on goethite:kinetic evaluation using a pressure-jump relaxation technique显示文摘 | Grossl P R Eick M SparksD L | 1997 | Environ Sci Technol1997，31，2： | 1 |
| 9 | Arsenate and chromate retention mechanisms on goethite:surface structure显示文摘 | Fendorf S Eick M J Grossl P R | 1997 | Environ Sci Technol1997，31，2： | 1 |
| 10 | Adsorption of arsenate (Ⅴ) and arsenite (Ⅲ) on goethite in the presence and absence of dissolved organic carbon显示文摘 | Grafe M Eick M J Grossl P R | 2001 | Soil Sci Soc Am J2001，65，： | 1 |
| 11 | Reference Values for Vertebral Artery Flow Volume by Duplex Sonography in Young and Elderly Adults显示文摘 | ZSeidel E Eicke B M Tettenborn B | 1999 | Stroke1999，30，： | 1 |
| 12 | Adsorption of arsenate and arsenite on ferrihydrite in the presence and absence of dissolved organic carbon显示文摘 | Grafe M Eick M J Grossl P R | 2002 | Journal of Environmental Quality2002，31，4： | 1 |
| 13 | Reference values for vertebral alery flow volume by duplex sonograph in young and elderly adults 显示文摘 | Eicke B M Seidel E Tettenborn B | 1999 | Stroke1999，30，12： | 1 |
| 14 | Practicability of combined treatment with calciporticol/betamethasone gel and improvement of quality of life in patients with psoriasis 显示文摘 | Sticherling M Eicke C Anger T | 2013 | J Dtsch Dermatol Ges2013，11，5： | 1 |
| 15 | Low-- frequence uhm--sound induces nonenzymatle thrombolysis in vitro显示文摘 | Nedelmann M Eicke M Lierke EG | 2002 | J Ultra - sound M ed2002，21，： | 1 |
| 16 | Arsenate and Chromate Retention Mechanisms on Goethite:Kinetic Evaluation Using a Pressure -Jump Relaxation Technique显示文摘 | Grossl P Eick M J Sparks D et at | 1997 | Environ Sci Teehno 11997，31，2： | 1 |
| 17 | Radiofrequency catheter ablation using cooled electrodes: Impact of irrigation flow rate and catheter contact pressure on lesion dimensions显示文摘 | Weiss C Antz M Eick O | 2002 | PACE2002，25，： | 1 |
| 18 | Electrochemical oscillations in the methanol oxidation on Pt显示文摘 | LEE J EICKES C EISWIRTH M ERTL GERHARD | 2002 | Electrochim Acta2002，47，： | 1 |
| 19 | 查看详情显示文摘 | Caballero R Kaufmann C A Eisenbarth T Cancela M Hesse R Unold T Eicke A Klenk R Schock H W | | 0，，： | 1 |
| 20 | The effectiveness of two sonic and two ultrasonic scaler tips in furcations显示文摘 | Patterson M Eick JD Eberhart AB | 1989 | J Periodont1989，60，6： | 1 |
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