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| 1 | Yes-associated protein(YAP)in pancreatic cancer:at the epicenter of a targetable signaling network associated with patient survival显示文摘Pancreatic ductal adenocarcinoma(PDAC)is generally a fatal disease with no efficacious treatment modalities.Elucidation of signaling mechanisms that will lead to the identification of novel targets for therapy and chemoprevention is urgently needed.Here,we review the role of Yes-associated protein(YAP)and WW-domain-containing Transcriptional co-Activator with a PDZbinding motif(TAZ)in the development of PDAC.These oncogenic proteins are at the center of a signaling network that involves multiple upstream signals and downstream YAP-regulated genes.We also discuss the clinical significance of the YAP signaling network in PDAC using a recently published interactive open-access database(www.proteinatlas.org/pathology)that allows genome-wide exploration of the impact of individual proteins on survival outcomes.Multiple YAP/TEAD-regulated genes,including AJUBA,ANLN,AREG,ARHGAP29,AURKA,BUB1,CCND1,CDK6,CXCL5,EDN2,DKK1,FOSL1,FOXM1,HBEGF,IGFBP2,JAG1,NOTCH2,RHAMM,RRM2,SERP1,and ZWILCH,are associated with unfavorable survival of PDAC patients.Similarly,components of AP-1 that synergize with YAP(FOSL1),growth factors(TGFα,EPEG,and HBEGF),a specific integrin(ITGA2),heptahelical receptors(P2Y2R,GPR87)and an inhibitor of the Hippo pathway(MUC1),all of which stimulate YAP activity,are associated with unfavorable survival of PDAC patients.By contrast,YAP inhibitory pathways(STRAD/LKB-1/AMPK,PKA/LATS,and TSC/mTORC1)indicate a favorable prognosis.These associations emphasize that the YAP signaling network correlates with poor survival of pancreatic cancer patients.We conclude that the YAP pathway is a major determinant of clinical aggressiveness in PDAC patients and a target for therapeutic and preventive strategies in this disease. | Enrique Rozengurt James Sinnett-Smith Guido Eibl | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 11 |
| 2 | Are acute exacerbations of chronic inflammatory appendicitis triggered by coprostasis and/or coproliths?显示文摘AIM: To examine the role of coprostasis and coproliths in recurrent appendicitis. METHODS: We evaluated four hundred and twenty seven consecutive pathology reports of all appende- ctomy specimens from January 2003 to December 2004. Findings were categorised as showing acute appen- dicitis, acute recurrent appendicitis, subacute recurrent appendicitis, chronic appendicitis, or appendices without inflammation. All patients had presented with acute right lower quadrant pain. In 94 instances, there was a history of recurrent similar episodes in the past. RESULTS: Of the 427 histology reports, 294 were inter- preted as showing acute appendicitis, 56 acute recurrent appendicitis, 34 subacute recurrent appen-dicitis, 28 chronic appendicitis, and 15 non-inflamed appendices. Coprostasis was observed in 58 patients (13.58%) and the presence of coprolith in 6 (1.4%). Coprostasis, and age, were among the predictors in the final model. CONCLUSION: Coprostasis but not coproliths seems to be a contributing factor to acute exacerbations of chronic inflammatory appendicitis. | George Sgourakis Georgios C Sotiropoulos Ernesto P Molmenti Charis Eibl Stylianous Bonticous Jurgen Moege Christoph Berchtold | 2008 | World Journal of Gastroenterology2008，14，20： | 5 |
| 3 | Neoadjuvant therapy in pancreatic adenocarcinoma: A meta-analysis of phase II trials显示文摘 | M. Mura Assifi Xuyang Lu Guido Eibl Howard A. Reber Gang Li O. Joe Hines | 2011 | Surgery2011，，3： | 3 |
| 4 | Growth of thick chemical solution derived pyrochlore La 2 Zr 2 O 7 buffer layers for YBa 2 Cu 3 O 7? x coated conductors显示文摘 | K. Knoth R. Hühne S. Oswald L. Molina O. Eibl L. Schultz B. Holzapfel | 2007 | Thin Solid Films2007，，8： | 3 |
| 5 | Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development显示文摘Pancreatic ductal adenocarcinoma(PDAC) remains a deadly disease with no efficacious treatment options. PDAC incidence is projected to increase, which may be caused at least partially by the obesity epidemic. Significantly enhanced efforts to prevent or intercept this cancer are clearly warranted. Oncogenic KRAS mutations are recognized initiating events in PDAC development, however, they are not entirely sufficient for the development of fully invasive PDAC.Additional genetic alterations and/or environmental, nutritional, and metabolic signals, as present in obesity, type-2 diabetes mellitus, and inflammation, are required for full PDAC formation. We hypothesize that oncogenic KRAS increases the intensity and duration of the growth-promoting signaling network.Recent exciting studies from different laboratories indicate that the activity of the transcriptional co-activators Yes-associated protein(YAP) and WW-domaincontaining transcriptional co-activator with PDZ-binding motif(TAZ) play a critical role in the promotion and maintenance of PDAC operating as key downstream target of KRAS signaling. While initially thought to be primarily an effector of the tumor-suppressive Hippo pathway, more recent studies revealed that YAP/TAZ subcellular localization and co-transcriptional activity is regulated by multiple upstream signals. Overall, YAP has emerged as a central node of transcriptional convergence in growth-promoting signaling in PDAC cells. Indeed, YAP expression is an independent unfavorable prognostic marker for overall survival of PDAC. In what follows, we will review studies implicating YAP/TAZ in pancreatic cancer development and consider different approaches to target these transcriptional regulators. | Enrique Rozengurt Guido Eibl | 2019 | World Journal of Gastroenterology2019，25，15： | 2 |
| 6 | 添加碳纳米管对选区激光熔化AlSi10Mg合金缺陷的影响显示文摘利用选区激光熔化成形技术制备了纯AlSi10Mg合金及碳纳米管(carbon nanotubes,CNTs)-AlSi10Mg复合材料。当添加CNTs含量为0.05%(质量分数)时具有一定增强效果,但随着CNTs添加量增大,复合材料性能却因为缺陷的增加而明显下降。木实验利用纳米CT技术对纯合金及CNTs(0.5%)-AlSi10Mg复合材料进行缺陷的三维重构。结果表明,添加0.5%的CNTs后,成形缺陷体积所占比例由12%增加至46%;气孔型缺陷数量明显增加,并且等效直径相对较大。CNTs在粉体中的团聚及对气体的吸附作用是两种类型缺陷增加的根本原因。 | 刘西河 赵聪聪 周鑫 刘伟 沈志坚 Florian Eibl Wilhelm Meiners | 2019 | 稀有金属材料与工程2019，48，5： | 2 |
| 7 | Persistent Multiple Organ Microcirculatory Disorders in Severe Acute Pancreatitis: Experimental Findings and Clinical Implications显示文摘 | T. Foitzik G. Eibl B. Hotz H. Hotz S. Kahrau C. Kasten P. Schneider H.J. Buhr | 2002 | Digestive Diseases and Sciences2002，，1： | 2 |
| 8 | Interlayer structure in YBCO-coated conductors prepared by chemical solution deposition显示文摘 | Leopoldo Molina-Luna Ricardo Egoavil Stuart Turner Thomas Thersleff Jo Verbeeck Bernhard Holzapfel Oliver Eibl Gustaaf Van Tendeloo | 2013 | Superconductor Science and Technology2013，，7： | 2 |
| 9 | Endovascular treatment and complete regression of an infected abdominal aortic aneurysm显示文摘 | Berchtold C Eibl C Seelig MH | 2002 | J Endovasc Ther2002，9，4： | 1 |
| 10 | Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer显示文摘 | Duffy JP Eibl G Reber HA | 2003 | Mol Cancer2003，2，1： | 1 |
| 11 | Persistent multiple organ mi- crocirculatory disorder in severe acute pancreatitis显示文摘 | Poitzik T Eibl G Hotz B | 2002 | Dig Dis Sci2002，47，1： | 1 |
| 12 | Therapy for microcirculatory disorders in severe acute pancreatitis:comparison ofdelayed therapy with ICAM-1antibodies and a specific endothelin a receptor antagonist显示文摘 | Foitzik T eibl G | 2000 | Journal of Gastrointestinal Surgery2000，4，3： | 1 |
| 13 | Multiclass boosting for weak classifiers 显示文摘 | Eibl G Pfeiffer K P | 2005 | The Journal of Machine Learning Research2005，，： | 1 |
| 14 | Design of concrete structures to resist accidental impact 显示文摘 | Eibl J | 1987 | Structural Engineering1987，65，17： | 1 |
| 15 | Persistent multiple organ micro- circulatory disorders in severe acute pancreatitis: experimental findings and clinical implications 显示文摘 | Foitzik T Eibl G Hotz B | 2002 | Dig Dis Sci2002，47，1： | 1 |
| 16 | Disposable bioreactors for plant liquid cultures at Litre-seale显示文摘 | EIBL R WERNER S EIBL D | 2009 | Engineering in Life Sciences2009，9，3： | 1 |
| 17 | Challenges and oppor-tunities in presbycusis 显示文摘 | Parham K McKinnon BJ Eibling D | 2011 | Otolaryngol Head Neck Surg2011，144，： | 1 |
| 18 | Experimental models of acute pancreatitis: are they suitable for evaluating therapy?显示文摘 | Foitzik T Hotz HG Eibl G | 2000 | Int J Colorectal Dis2000，15，3： | 1 |
| 19 | Clear background and highly sensitive protein staining with Coomassie blue dyes in polyacrylamide gels: A systematic analysis显示文摘 | Neuhoff Stamm R Eibl H | 1985 | Electrophoresis1985，6，9： | 1 |
| 20 | Effect of endothelin and endothelin receptor blockade on capillary permeability in experimental panereatitis显示文摘 | Eibl G Hotz HG Faulhaber J | 2000 | Gut2000，46，3： | 1 |
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