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| 1 | Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function显示文摘Innate immunity mediated by Toll-like receptors(TLRs),which can recognize pathogen molecular patterns,plays a critical role in type 1 diabetes development.TLR7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and host tissue cells;however,its role in type 1 diabetes development remains unclear.In our study,we discovered that Tlr7-deficient(Tlr7^(−/−))nonobese diabetic(NOD)mice,a model of human type 1 diabetes,exhibited a significantly delayed onset and reduced incidence of type 1 diabetes compared with Tlr7-sufficient(Tlr7^(+/+))NOD mice.Mechanistic investigations showed that Tlr7 deficiency significantly altered B-cell differentiation and immunoglobulin production.Moreover,Tlr7^(−/−)NOD B cells were found to suppress diabetogenic CD4^(+)T-cell responses and protect immunodeficient NOD mice from developing diabetes induced by diabetogenic T cells.In addition,we found that Tlr7 deficiency suppressed the antigen-presenting functions of B cells and inhibited cytotoxic CD8^(+)T-cell activation by downregulating the expression of both nonclassical and classical MHC class I(MHC-I)molecules on B cells.Our data suggest that TLR7 contributes to type 1 diabetes development by regulating B-cell functions and subsequent interactions with T cells.Therefore,therapeutically targeting TLR7 may prove beneficial for disease protection. | Juan Huang Jian Peng James Alexander Pearson Georgios Efthimiou Youjia Hu Ningwen Tai Yanpeng Xing Luyao Zhang Jianlei Gu Jianping Jiang Hongyu Zhao Zhiguang Zhou F.Susan Wong Li Wen | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis显示文摘Bacteria of the human intestinal microflora have a dual role.They promote digestion and are part of a defense mechanism against pathogens.These bacteria could become potential pathogens under certain circumstances.The term“bacterial translocation”describes the passage of bacteria of the gastrointestinal tract through the intestinal mucosa barrier to mesenteric lymph nodes and other organs.In some cases,the passage of bacteria and endotoxins could result in blood stream infections and in multiple organ failure.Open elective abdominal surgery more frequently results in malfunction of the intestinal barrier and subsequent bacterial translocation and blood stream infections than laparoscopic surgery.Postoperative sepsis is a common finding in patients who have undergone non-elective abdominal surgeries,including trauma patients treated with laparotomy.Postoperative sepsis is an emerging issue,as it changes the treatment plan in surgical patients and prolongs hospital stay.The association between bacterial translocation and postoperative sepsis could provide novel treatment options. | Christos Doudakmanis Konstantinos Bouliaris Christina Kolla Matthaios Efthimiou Georgios D Koukoulis | 2021 | World Journal of Gastrointestinal Pathophysiology2021，12，6： | 2 |
| 3 | Diagnosis and management of adult onset Still's disease显示文摘 | Efthimiou P Paik PK Bielory L | 2006 | Ann Rheum Dis2006，65，5： | 1 |
| 4 | Diagnosis and management of a- dult onset Still's disease 显示文摘 | Efthimiou P Paik PK Bielory L | 2006 | Annals of the Rheumatic Disease2006，65，5： | 1 |
| 5 | 进食频率预测新发高血压及血压、动脉硬化和脉搏波反射进展率显示文摘普遍认为每天至少吃3餐,但现代生活方式正逐渐打破既往进食习惯。已发现每日进食频率可能影响多种心血管代谢风险因素,但尚未深入研究其临床价值。研究显示,与进食次数较少者相比,进食次数较多者通常血脂状况更好,胰岛素抵抗及代谢综合征发病风险更低。进食频率增加使空腹时间减少,平均血糖浓度及胰岛素分泌量降低。胰岛素浓度降低使羟甲基戊二酸单酰辅酶A还原酶活性降低,从而减少肝脏胆固醇合成。 | Karatzi K Georgiopoulos G Yannakoulia M Efthimiou E Voidonikola P Mitrakou A Manios E Alevizaki M Papamichael C Stamatelopoulos K 曲浥晨 | 2016 | 中华高血压杂志2016，24，5： | 1 |
| 6 | Diagnosis and management of adult onset Still's disease显示文摘 | Efthimiou P Paik PK Bielory L | 2006 | Annals of the Rheumatic Disease2006，65，5： | 1 |
| 7 | Phrenic nerve and diaphragm function following open heart surgery:a prospective study with and without topical hypothermia显示文摘 | Efthimiou J Butler J Woodham C | | 0，，307： | 1 |
| 8 | Adult-onset Still's disease: pathogenesis, clinical manifestations and therapeutic advances 显示文摘 | Kontzias A Efthimiou P | 2008 | Drugs2008，68，3： | 1 |
| 9 | Effect of prickly pear( O- puntia robusta) on glucose 2 and lipid 2 metabolism in nondiabetics with hyperlipidemia-a pilot study 显示文摘 | Wolfram R M Kritz H Efthimiou Y | 2002 | Wien Klin Wochenschr2002，114，： | 1 |
| 10 | Adult-onset Still's disease- pathogenesis, clinical manifestations, and new treatment options显示文摘 | Kadavath S Efthimiou P | 2015 | Ann Med2015，47，1： | 1 |
| 11 | IL-1 Trap rilonacept in refractory adult onset Still' s disease 显示文摘 | Petryna O Cush JJ Efthimiou P | 2012 | Ann Rheum Dis2012，71，12： | 1 |
| 12 | Plasma concentrations of lignocaine during fibeoptic bronchoscopy显示文摘 | Efthimiou J Higenbottam T Holt D | 1982 | Thorax1982，37，1： | 1 |
| 13 | Effect of prickly pear(Opuntia robusta) on glucose and lipid metabolism in nondiabetics with hyperlipidemia --a pilot study显示文摘 | WOLFRAM R M KRITZ H EFTHIMIOU Y | 2002 | Wien Klin Wochenschr2002，114，： | 1 |
| 14 | Pos sible role for tumour necrosis factor inhibi tors in the treatment of resistant dermatomy osiris and polymyositis:a retrospective study of eight patients显示文摘 | Efthimiou P Schwartzman S Kagen LJ | 2006 | Ann Rheum Dis2006，65，9： | 1 |
| 15 | Diagnosis and management of adult onset Still's disease 显示文摘 | EFTHIMIOU P PAIK P K BIELORY L | 2006 | Ann Rheum Dis2006，65，5： | 1 |
| 16 | The effect of supple- mentary oral nutrition in poorly nourished patients with chronic obstructive pulmonary disease显示文摘 | Efthimiou J Fleming J Gomes C | 1988 | Am Rev Respir Dis1988，137，5： | 1 |
| 17 | The effect of information literacy on physical education students’ perception of a course management system显示文摘 | Nikolaos Vernadakis Panagiotis Antoniou Maria Giannousi Eleni Zetou Efthimis Kioumourtzoglou | 2011 | Learning Media and Technology2011，，4： | 1 |
| 18 | Complementary and alternative medicine use in rheumatoid arthritis: proposed mechanism of action and efficacy of commonly used modalities 显示文摘 | Efthimiou P Kukar M | 2010 | Rheumatol Int2010，30，5： | 1 |
| 19 | Open inguinal hernia repair with the use of a polyglcolic acid - trimethylene carbonate ab- serbable mesh:a pilot study显示文摘 | Efthimiou M Symeonidis D Koukoulis G | 2011 | Hernia2011，15，2： | 1 |
| 20 | Adult-onset Still's disease显示文摘 | Kontzias A Efthimiou P | 2008 | Drugs2008，68，3： | 1 |
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