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| 1 | Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis显示文摘AIM: To investigate the effects of troglitazone (TGZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in rats.METHODS: Rats were supplemented with TGZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham operation.Animals were killed at 1, 2, or 4 wk after surgery.RESULTS: The development of liver fibrosis was reduced in rats receiving TGZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TGZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TGZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (GGT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system. | Fabio Marra Raffaella DeFranco Gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola | 2005 | World Journal of Gastroenterology2005，11，32： | 9 |
| 2 | Nonsurgical internalbiliary drainage by endoprosthesis显示文摘 | Burcharth F Efsen F Christiansen LA | 1981 | SGO1981，153，： | 1 |
| 3 | Ligands of per- oxisome pro- life tater-activated receptory modulate profi- brogenic and proinfla matory actions in hepatic stellate cells 显示文摘 | Marry F Efsen E Romanelli RG | 2000 | Gastroen terology2000，119，： | 1 |
| 4 | TB meningitis in HIV-positive patients in Europe and Argentina:clinical outcome and factors associated with mortality显示文摘 | Efsen AM Panteleev AM Grint D | 2013 | Biomed Res Int2013，2013，37： | 1 |
| 5 | Ligands of peroxisome pro liferator -activated receptor gamma modulate profbrogenic and pr oinflammatory actions in hepatic stellate cells显示文摘 | Marra F Efsen E Romanelli RG | 2000 | Gastroenterology2000，119，2： | 1 |
| 6 | Ligands of peroxisome proliferator activated receptor gamma modulate profibrogenic and proinfiammatory actions in hepatic stellate cells显示文摘 | Marra F Efsen E Romanelli RG et at | 2000 | Gastroenterology2000，119，： | 1 |
| 7 | Ligands of peroxi some proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells显示文摘 | Marra F Efsen E Romanelli RG | 2000 | Gastroenterology2000，119，： | 1 |
| 8 | Changes in skin redness, pigmentation, echo structure thickness and surface contour after 1 pulsed dye laser treatment of port wine stains in children显示文摘 | Haedersdal M Efsen J Gniadecka M | 1998 | Arch Dermatol1998，134，2： | 1 |
| 9 | Up-regulated expression of fractalkine and its receptor CX3CR1 during liver injury in humans显示文摘 | Efsen E Grappone C DeFranco RM | 2002 | J Hepato12002，37，1： | 1 |
| 10 | Up-regulated expression of fractalkine and its receptor CX3CRI during liver injury in humans显示文摘 | Efsen E Grappone C DeFranco RM | 2002 | J Hepatol2002，37，1： | 1 |
| 11 | Myocardial blood flow rate and capillary permeability for 99mTc-DTPA in patients with angiographically normal coronary arteries 显示文摘 | SVENDSEN J H KELBAEK H EFSEN F | 1994 | Cardiology1994，85，： | 1 |
| 12 | Ligands of peroxi- some proliferator-activated receptor r modulate profrbrogenic and proinflammatory actions in hepatic stellate cells 显示文摘 | Marra F Efsen E Romanelli RG | 2000 | Gastroenterol2000，119，2： | 1 |
| 13 | Ligands of peroxisome proliferator- activated receptor gamma modulate profibrogenic and proinilammatory actions in hepatic stellate cells显示文摘 | MARRA F EFSEN E ROMANELLI R G | 2000 | Gastroenterology2000，119，： | 1 |
| 14 | Ligands of peroxisome proliferator- activator receptor- γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells显示文摘 | Marra F Efsen E Romanelli RG | 2000 | Gastroenterology2000，119，2： | 1 |
| 15 | Up - regulation expression of fractalkine and its receptor CX3CR1 during liver injury in humans 显示文摘 | Eva Efsen Cecilia Grappone Raffaella MS | 2002 | J Hepatol2002，37，1： | 1 |
| 16 | Agonist-specific regulation of monocyte chemoattractant protein-1 expression by cyclooxygenase metabolites in hepatic stellate cells显示文摘 | Efsen E Bonacchi A Pastacaldi S | 2001 | Hepatology2001，33，： | 1 |
| 17 | Ligands of Peroxisome Proliferator-activated Receptor Gamma Modulate Profibrogenic and Proinflammatory Actions in Hepatic Stellate Cells 显示文摘 | Marra F Efsen E Romanelli R G | 2000 | Gastroenterology2000，119，2： | 1 |
| 18 | 显示文摘 | Marra F Efsen E Romanelli RG | 2000 | J Biol Chem2000，275，35： | 1 |
| 19 | Ligands of peroxisom proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells显示文摘 | MARRA F EFSEN E ROMANELLI RG | 2000 | Gastroenterology2000，119，2： | 1 |
| 20 | Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells显示文摘 | MARRA F EFSEN E ROMANELLI R G | 2000 | Gastroenterology2000，119，2： | 1 |
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