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| 1 | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease显示文摘Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment.The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s disease.Alzheimer’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus bilaterally.Morris water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after administration.Afterwards,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM antibodies.Results showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem cells.These findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s disease.All procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval No.CICUAL 2016-011)on April 25,2016. | Edwin E. Reza-Zaldivar Mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-Mercado Sergio Sandoval-ávila Ulises Gomez-Pinedo Ana L. Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre | 2019 | Neural Regeneration Research2019，14，9： | 19 |
| 2 | Early experience in human hybrid transgastric and transvaginal endoscopic cholecystectomy显示文摘 | Gustavo Salinas Lil Saavedra Hellen Agurto Rosa Quispe Edwin Ramírez José Grande Juan Tamayo Victoria Sánchez Daniel Málaga Jeffrey M. Marks | 2010 | Surgical Endoscopy2010，，5： | 2 |
| 3 | Distance-Based outliers: Algorithms and Applications 显示文摘 | Edwin M Knorr Raymond T Ng and Vladimir Tucakov | 2000 | The VLDB Journal2000，8，3： | 2 |
| 4 | Proteomics and ovarian cancer: implications for diagnosis and treatment: a critical review of the recent literature显示文摘 | Posadas Edwin M Davidson | 2004 | Curr Opin Oncol2004，16，5： | 1 |
| 5 | Melamine formaldehyde core decomposition as the key step controlling capsule integrity:Optimizing the polyelectrolyte capsulefabrication显示文摘 | Gao Changyou Edwin Donath Helmuth M o¨ hwald | 2002 | Chem Phys2002，203，7： | 1 |
| 6 | New chiral olgopyridines- 4,4 ~ - his ( disaccharide)-functionalized 2,2 ' - bipyridines and 4 ' - (disaccharide) functionalized 2,2 ' : 6 ', 2' terpyridines 显示文摘 | Edwin C C Catherine E H Azad M | 2008 | Carbohydrate Research2008，343，： | 1 |
| 7 | Distance-based Outliers:Algorithms and Applications显示文摘 | Edwin M K Raymond T N Vladimir Tucakov | 2000 | VLDB Journal2000，324，8： | 1 |
| 8 | The Corporate Social Policy Process: Beyond Business Ethics, Corporate Social and Corporate Social Responsibility and Corporate Social Responsiveness 显示文摘 | Edwin M Epstein | 1987 | California Management Review1987，，3： | 1 |
| 9 | Antioxidant activity of grape extracts in a lecithin liposome syste 显示文摘 | Ock-snook Y Anne S M Edwin N F | 1997 | JAOCS1997，74，10： | 1 |
| 10 | High rate sputter deposition of wear resistant tantalum coatings 显示文摘 | Mastson Dean W Merz M D McClanallan Edwin D | 1992 | Journal of Vacuum Science and Technology1992，10，4： | 1 |
| 11 | A utility-based power-control scheme in wireless cellular systems显示文摘 | Xiao M Shroff N B Edwin K P | 2003 | IEEE/ACM Trans Networking2003，11，2： | 1 |
| 12 | A multilevel investigation of the motivational mechanisms underlying knowledge sharing and performance显示文摘 | Quigley Narda R Tesluk Paul E Locke Edwin A Bartol Kathryn M | 2007 | Organization Science2007，18，1： | 1 |
| 13 | Distribution of cell adhesion molecules in decidua of early human pregnancy显示文摘 | Klaus M Edwin K | 1994 | Lab Invest1994，71，1： | 1 |
| 14 | Prevention of IHHNV vertical transmission in the white shrimp Litopenaeus vannamei显示文摘 | Emmerik M Edwin Y Juan L | 2003 | Aquaculture2003，219，： | 1 |
| 15 | International Protection of Intellectual Property 显示文摘 | Grossman Gene M Edwin L - C Lai | 2004 | The American Economic Review2004，94，5： | 1 |
| 16 | Role of the gut in multiple organ failure:bacterial translacation and premaeability changes显示文摘 | Edwin A | 1996 | Word J Surg1996，20，4： | 1 |
| 17 | The corporate social policy process:Beyond business ethics,corporate social responsibility and corporate social Responsiveness显示文摘 | Epstein Edwin M | 1987 | California Management Review1987，，29： | 1 |
| 18 | Resveratrol: influences on gene expression in human skin 显示文摘 | EDWIN D L JOHN M S MERRITT B A | 2014 | Journal of Functional Foods2014，10，： | 1 |
| 19 | The shape of the sunspot cycle 显示文摘 | Hathaway David H Wilson Robert M Reichmann Edwin J | 1994 | Solar Phys1994，151，： | 1 |
| 20 | Business Ethics,Corporate Good Citizenship and the Corporate Social Policy Process:A View form the United States显示文摘 | Epstein Edwin M | 1989 | Journal of Business Ethics1989，8，8： | 1 |
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