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2篇 您的检索式:作者名="Edwin C. Mo"
    题名 作者 年代 出处 被引量
1A study of circulating interleukin 10 in prognostication of unresectable hepatocellular carcinoma显示文摘Stephen L. Chan Frankie K. F. Mo Cesar S. C. Wong Charles M. L. Chan Linda K. S. Leung Edwin P. Hui Brigette B. Ma Anthony T. C. Chan Tony S. K. Mok Winnie Yeo 2011Cancer2011,,16:2
2Production of Hypoxia-induced Corneal Edema in Aged Eyes显示文摘Purpose:Corneal thickness assessment is a common clinical procedure applied in corneal and contact lens care. This study aims to investigate the effect of age on hypoxia-induced corneal swelling.Methods:Eighteen male subjects were equally divided into the younger [(23.7 ± 0.8) years old] and older [(74.4 ± 2.5) years old] groups. Each subject wore a thick soft contact lens (uniform thickness of 0.3 mm) on the left cornea. With the contact lens in place, the baseline central corneal thickness was measured using a specially designed photo-pachometer. The lens was then patched behind the closed eyelids, producing an extremely hypoxic stress to the cornea. The change in central corneal thickness was monitored every 20 minutes with momentary disruptions to the hypoxic stress over the next 2 hours. The increase in thickness was taken as an index of corneal edema. The rate of change in corneal thickness, as derived from a non-linear mathematical model, was compared between groups.Results:The corneal thickness of both age groups increased significantly with time (P<0.000 1). The mean corneal swelling constant for the older subjects was 16.5 × 10-3 (S.E.M. = 2.65 × 10-3) and the value for the younger subjects was 46.5 × 10-3 (S.E.M. = 3.25 × 10-3). The difference was statistically significant (P < 0.000 1).Conclusion:Aging cornea has a slower hypoxia-induced edema response compared with the younger group. Whether it is caused by a decreased corneal lactate production or an increased resistance to physical expansion deserves further investigation. Eye Science 2004;20:1-5.Alan K. Cheung Andrew W. Siu Digby W. Cheung Edwin C. Mo 2004Eye Science2004,20,1:0
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