维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

6篇 您的检索式：作者名="Edith Mathiowitz"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Characterization of Hydrolytically Degradable Amino Acid Containing Poly(Anhydride-co-Imides)显示文摘	Andrea Staubli Edith Mathiowitz Melissa Lucarelli	1991	Macromolecules1991，24，：	1
	2	Nanosphere based oral insulin delivery 显示文摘	Carino GP Jacob JS Mathiowitz Edith	2000	J Control Release2000，65，12：	1
	3	Nanosphere based oral insulin delivery 显示文摘	Gerardo P Carino Jules S Jacob Edith Mathiowitz	2000	Journal of Controlled Release2000，65，：	1
	4	显示文摘		2001	Journal of Applied Polymer Science2001，80，：	1
	5	Intratumoral IL-12 and TNF-α–Loaded Microspheres Lead To Regression of Breast Cancer and Systemic Antitumor Immunity显示文摘	Michael S. Sabel MD Joseph Skitzki MD Lloyd Stoolman MD Nejat K. Egilmez PhD Edith Mathiowitz PhD Nicola Bailey PhD Wen-Jian Chang MD Alfred E. Chang MD	2004	Annals of Surgical Oncology2004，，2：	1
	6	Oral encapsulated transforming growth factorβ1 reduces endogenous levels:Effect on inflammatory bowel disease显示文摘BACKGROUND TreXTAM®is a combination of the key regulatory cytokine transforming growth factor beta(TGFβ)and all trans retinoic acid(ATRA)microencapsulated for oral delivery to immune structures of the gut.It is in development as a novel treatment for inflammatory bowel disease(IBD).AIM To measure TGFβlevels in blood and tissue after oral administration of encapsulated TGFβ.METHODS Animals were orally administered encapsulated TGFβby gavage.Levels of drug substance in blood and in gut tissues at various times after administration were measured by ELISA.RESULTS We made the surprising discovery that oral administration of TreXTAM dramatically(approximately 50%)and significantly(P=0.025)reduced TGFβlevels in colon,but not small intestine or mesenteric lymph nodes.Similarly,levels in rat serum after 25 d of thrice weekly dosing with either TreXTAM,or microencapsulated TGFβalone(denoted as TPX6001)were significantly(P<0.01)reduced from baseline levels.When tested in the SCID mouse CD4+CD25-adoptive cell transfer(ACT)model of IBD,oral TPX6001 alone provided only a transient benefit in terms of reduced weight loss.CONCLUSION These observations suggest a negative feedback mechanism in the gut whereby local delivery of TGFβresults in reduced local and systemic levels of the active form of TGFβ.Our findings suggest potential clinical implications for use of encapsulated TGFβ,perhaps in the context of IBD and/or other instances of fibrosis and/or pathological TGFβsignaling.	Laura Hammer Stacia Furtado Edith Mathiowitz Dominick L Auci	2020	World Journal of Gastrointestinal Pharmacology and Therapeutics2020，11，5：	0

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费